Search results for "Development"

Brain stimulation procedures for treatment of contralesional spatial neglect

2011

The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can be modulated by brain stimulation: 1) neglect is highly lateralized deficit, 2) neglect is a network disorder in which lesion of a network node impacts affects excitability of intrahemispehric and interhemispheric connections, and 3) lesions of the right hemisphere, the most frequent cause of neglect, are associated with a transcallosally mediated increase of facilitation of t…

Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria

2019

The mucosal surfaces of animals are habitat for microbes, including viruses. Bacteriophages—viruses that infect bacteria—were shown to be able to bind to mucus. This may result in a symbiotic relationship in which phages find bacterial hosts to infect, protecting the mucus-producing animal from bacterial infections in the process. Here, we studied phage binding on mucus and the effect of mucin on phage-bacterium interactions. The significance of our research is in showing that phage adhesion to mucus results in preventive protection against bacterial infections, which will serve as basis for the development of prophylactic phage therapy approaches. Besides, we also reveal that exposure to m…

Territory and memory: The Landing of the Allies in Sicily in 1943

2012

The concept of memory (memorial site) has gained crucial importance in recent years for the identification of places (areas) and in the affirmation of local identities. The memorial sites are areas where usually tragic events have occurred and resulted in a cultural change. In these places there are still signs of these historical events and/or tangible and intangible indications created by the society such as: monuments, obelisks, marble inscriptions, others. Sicily represents an ideal area for studying memorial sites; not only because of the number of dominations in the past centuries, but also for the significance of all places where the mafia has taken its root. These elements have caus…

Psychosocial Safety Climate: A New Work Stress Theory and Implications for Method

2019

This book responds to a public health priority (Whiteford et al., 2013) and a call from the WHO (2016), ILO (2016) and OECD (2012) to prevent and manage mental ill-health and promote health and well-being by drawing attention to the connection between work and mental health. By demonstrating a link between work factors and mental health-related issues, this book will provide public policy makers with evidence needed to shift policy attention to create mentally healthy workplaces and move investment of health, compensation, and insurance funding into proactive prevention strategies rather than costly treatments, medications, therapy, and hospitalisation. Ensuring workplaces globally have the…

Running a hybrid: mingling in-service and pre-service teachers in peer-mentoring groups

2020

his study examines a hybrid form of the Finnish Peer-Group Mentoring (PGM) merging student teachers and in-service teachers of different career stages in group meetings facilitated by an educated mentor. Experiences of the in-service participants were studied by interviewing them, and the data were analysed through thematic analysis. Four main themes were identified: 1) Enjoying group activities, 2) Personal professional development, 3) Attaching to the professional community and 4) Developing the teacher profession. The study shows that the hybrid model of peer-group mentoring enables opportunities for teacher learning that benefit both schools and teacher education institutions. peerRevie…

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions

2021

BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…

Tietokoneavusteinen mallinnus rakenteisten asiakirjastandardien kehittämisessä

1998

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

2012

Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…

Tolerance of Whitefish (Coregonus Lavaretus) Early Life Stages to Manganese Sulfate is Affected by the Parents

2017

European whitefish (Coregonus lavaretus) embryos and larvae were exposed to 6 different manganese sulfate (MnSO4) concentrations from fertilization to the 3-d-old larvae. The fertilization success, offspring survival, larval growth, yolk consumption, embryonic and larval Mn tissue concentrations, and transcript levels of detoxification-related genes were measured in the long-term incubation. A full factorial breeding design (4 females × 2 males) allowed examination of the significance of both female and male effects, as well as female–male interactions in conjunction with the MnSO4 exposure in terms of the observed endpoints. The MnSO4 exposure reduced the survival of the whitefish early li…

Isolation and Culture of Oligodendrocytes

2019

Primary cultures of brain-derived rodent cells are widely used to study molecular and cellular mechanisms in neurobiology. In this chapter, we describe methods of purifying and culturing oligodendroglial cells from mouse perinatal brains. In addition, we describe methods of coculturing the purified oligodendrocytes with neurons. When prepared and cultured according to these protocols, many essential aspects of the biology of oligodendrocytes, such as their proliferation, differentiation, and myelination, can be studied in culture.