Search results for "Developmental Neuroscience"

Verbal and academic skills in children with early-onset type 1 diabetes

2010

Aim  Basic verbal and academic skills can be adversely affected by early-onset diabetes, although these skills have been studied less than other cognitive functions. This study aimed to explore the mechanism of learning deficits in children with diabetes by assessing basic verbal and academic skills in children with early-onset diabetes and in comparison children. In addition, the incidence of dyslexia (≤10th centile in reading speed or reading–spelling accuracy) was studied. Method  The performance of 51 children with early-onset diabetes (25 females, 26 males; mean age 9y 11mo, SD 4mo; range 9–10y) was compared with that of 92 children without diabetes (40 females, 52 males; mean age 9y 1…

P3‐335: Upstream of N‐ras (UNR) is involved in translational control of ADAM10 protein expression

2008

Background: The amyloid beta peptide (A ) is derived by proteolytic processing of the amyloid precursor protein (APP) by the beta-secretase BACE1 and gamma-secretase. In contrast to this amyloidogenic processing, APP is predominantly cleaved by the alpha-secretase within the A domain and this precludes the formation of A . We and other research groups could show that BACE1 protein expression is regulated by the 5’untranslated region (UTR) of the BACE1 mRNA, however little is known about the regulation of alpha-secretase. Similar to the 5’UTR of BACE1, the 5’UTR of ADAM10 consists of 444 nucleotides with a GC-content of 70% and two upstream open reading frames. We hypothesize that ADAM10, th…

2016

Processing natural scenes requires the visual system to integrate local features into global object descriptions. To achieve coherent representations, the human brain uses statistical dependencies to guide weighting of local feature conjunctions. Pairwise interactions among feature detectors in early visual areas may form the early substrate of these local feature bindings. To investigate local interaction structures in visual cortex, we combined psychophysical experiments with computational modeling and natural scene analysis. We first measured contrast thresholds for 2x2 grating patch arrangements (plaids), which differed in spatial frequency composition (low, high or mixed), number of gr…

The Development of Visuo-spatial Memory: How to Remember Location

1992

Recent studies on developmental differences in spatial memory have reported equivocal results. Some found an age-dependent improvement of memory performance whereas others did not. The two studies reported here investigate age differences in memory for visual-spatial information. A picture reconstruction task with simultaneous presentation of scene-like visual-spatial arrangements was used. Subjects had to recognise objects and to reconstruct the initial spatial arrangement. The first study with 5to 10year-olds produced the typical age-dependent improvement in recognising visual material as well as in remembering the locations of specific objects. No effect for age was obtained in memory f…

Associations between private speech, behavioral self-regulation, and cognitive abilities

2014

We examined the associations between 5-year-old children’s private speech, behavioural self-regulation, and cognitive abilities. Behavioural self-regulation was assessed using parental and preschool teacher questionnaires. Cognitive abilities (i.e., language, inhibition, planning and fluency, and memory) were assessed with neurocognitive tests, and the effectiveness of private speech (i.e., whether the child performs better when using speech than when not using speech) with the Hammer Task. About 43% of the children used private speech spontaneously, and about 76% performed better on the Hammer Task when they used speech. Associations between behavioural self-regulation and speech effectiv…

Editorial - Connecting the Dots: The Promises of Wharton's Jelly Mesenchymal Stem Cells for Tissue Repair and Regeneration

2011

Mesenchymal stem cells (MSC) constitute a variety of cellular populations which were described first about 35 years ago in the bone marrow (BM) stroma [1]. These years have foreseen an exponential increase of reports pointing out features, stemness, markers, tissue sources and clinical applications of these cells. Cells with MSC features can be isolated from virtually every adult organ in the body, as well from a group of fetus-associated sources (cells derived from the latter tissues are collectively known as perinatal stem cells) [2]. In recent years, the umbilical cord arose as a promising source of mesenchymal stem cells, which can be isolated in relatively high numbers (compared to BM)…

The structure of mental well-being and its relationship with generativity in middle adulthood and the beginning of late adulthood

2023

Previous studies have linked higher generativity with better mental well-being. However, most of these studies investigated the predictive role of generativity in well-being, while the converse relation, that is, how mental well-being contributes to generativity, has been ignored. This study first investigated the structure and stability of multidimensional mental well-being, that is, emotional (including happiness, life satisfaction, and positive and negative mood), psychological, and social well-being and the absence of depressive feelings, from age 42 to 61. Second, longitudinal associations between mental well-being and generativity were examined. The data ( n = 301) utilized in this s…

Understanding the Role of Sensorimotor Beta Oscillations

2021

Beta oscillations have been predominantly observed in sensorimotor cortices and basal\ud ganglia structures and they are thought to be involved in somatosensory processing\ud and motor control. Although beta activity is a distinct feature of healthy and pathological\ud sensorimotor processing, the role of this rhythm is still under debate. Here we review\ud recent findings about the role of beta oscillations during experimental manipulations (i.e.,\ud drugs and brain stimulation) and their alteration in aging and pathology. We show how\ud beta changes when learning new motor skills and its potential to integrate sensory input\ud with prior contextual knowledge. We conclude by discussing a n…

Descending Connections from the Brainstem to the Spinal Cord in the Electric Fish <i>Eigenmannia</i>

1990

The descending connections from the brainstem to the spinal cord in Eigenmannia sp. were demonstrated using the horseradish peroxidase (HRP) technique. The spinal cord was transecte

The Forebrain of the Blind Cave Fish <i>Astyanax hubbsi </i>(Characidae)

1997

This paper presents a survey of the cell groups in the telencephalon of the teleost Astyanax hubbsi, based on series of transverse sections stained with the Nissl-Kluver-Barrera and Bodian procedures. The work was conducted for two reasons. Firstly, it was intended to determine the contribution of the forebrain of blind cave fish to certain forms of behavior. An understanding of the anatomy of the telencephalic organization is essential for such a neuroethological approach. The second purpose was to provide the cytoarchitectural basis for the experimental analysis of the fiber connectivity of the telencephalon of A. hubbsi. Furthermore, information about the forebrain of characids is widely…