Search results for "Diagnostic methods"
showing 10 items of 39 documents
Human papillomavirus in saliva of patients with oral squamous cell carcinoma.
2008
Objective: The aim of this study was to evaluate the presence of human papillomavirus (HPV) in saliva rinses of patients with oral squamous cell carcinoma (OSCC)and to analyze the possibility of using saliva as a diagnostic method for screening high-risk patients. Study design: The saliva sample of 22 patients with oral squamous cell carcinoma and 20 age-sex matched healthy controls were obtained. The presence of HPV 6, 11, 16, 18, 31, and 33 was evaluated by polymerase chain reaction (PCR). Results: In 40.9% of the patients and in 25% of the controls, the saliva was shown to be positive for HPV. In 27.3% of the patients and in 20% of the controls, the saliva was shown to be positive for HP…
Very High Fascioliasis Intensities in Schoolchildren from Nile Delta Governorates, Egypt: The Old World Highest Burdens Found in Lowlands
2021
Quantitative coprological analyses of children were performed in Alexandria and Behera governorates, Egypt, to ascertain whether individual intensities in the Nile Delta lowlands reach high levels as those known in hyperendemic highland areas of Latin America. Analyses focused on subjects presenting intensities higher than 400 eggs per gram of faeces (epg), the high burden cut-off according to WHO classification. A total of 96 children were found to shed between 408 and 2304 epg, with arithmetic and geometric means of 699.5 and 629.07 epg, respectively. Intensities found are the highest hitherto recorded in Egypt, and also in the whole Old World. A total of 38 (39.6%) were males and 58 (60.…
Mesoscopic structure of marble determined by combined USANS and SANS
2006
Marbles, carbonatic (i.e. calcitic–dolomitic) rocks deriving from the metamorphic evolution of previous carbonates, are often rather similar to each other in many respects (i.e. mineralogical, physical–structural and chemical), and thus difficult to identify. In search for a diagnostic method to provenance marbles, we have selected a limited number of Italian white marbles representing a wide array of metamorphic (i.e. thermal) levels. The mesoscale structural arrangement of these samples was derived by means of combined Ultra Small Angle and Small Angle Neutron Scattering experiments. The parameters of the model used to fit the data have been correlated with the metamorphic history of the …
Human Thyroid Cancer Stem Cells
2011
Increasing advances in stem cell research have opened new chances for treatment of many types of cancers. The identification of Cancer Stem Cells (CSCs) will provide a better knowledge of the molecular events governing carcinogenesis and the establishment of more accurate diagnostic methods and effective therapies. Parallel to other tumors, it has been demonstrated the presence of CSCs in thyroid cancers. Here, we will discuss the origin of human thyroid cancer stem cells and what is known about the molecular and the cellular aspects of their biology. We will also explore the potential traits of CSCs in thyroid cancer which give hope for the development of new therapeutic approaches in trea…
Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum
2021
Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximu…
Diagnostics of autoimmune bullous diseases in German dermatology departments
2012
Summary Background: No consistent data are available on the currently employed diagnostic tools for autoimmune bullous diseases in Germany. The aim of this survey was to describe currently performed diagnostic methods for bullous autoimmune diseases in German dermatology departments. Methods: A standardized questionnaire evaluated the available diagnostic methods i. e. direct immunofluorescence microscopy (IFM), indirect IFM, commercial ELISA systems, and non-commercial serological tests as well as the number of samples per year in all 34 university and 39 non-university dermatology departments. Results: The overall return rate was 89 %, 100 % and 79 % for the university and non-university …
Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing st…
2021
Viruses are responsible for multiple infections in humans that impose huge health burdens on individuals and populations worldwide. Therefore, numerous diagnostic methods and strategies have been developed for prevention, management, and decreasing the burden of viral diseases, each having its advantages and limitations. Viral infections are commonly detected using serological and nucleic acid-based methods. However, these conventional and clinical approaches have some limitations that can be resolved by implementing other detector devices. Therefore, the search for sensitive, selective, portable, and costless approaches as efficient alternative clinical methods for point of care testing (P…
Assessment of somatoform disorders: a review of strategies and instruments.
2003
We provide an overview of methods and instruments developed for the assessment of somatoform disorders. Four diagnostic purposes have been identified: (i) classification according to a diagnostic system; (ii) screening for probable cases; (iii) dimensional measurement of syndrome severity; and (iv) assessment of associated clinical features. Existing instruments designed for each of these strategies are described, including specifications of their psychometric properties, particular features, advantages and disadvantages. A conclusion of this review is that the currently existing ‘family of assessment instruments’ in the field of somatoform disorders should be used to improve the comparabil…
Geographical variation in the exhaled volatile organic compounds.
2013
Breath-gas analysis has demonstrated that concentration profiles of volatile organic compounds (VOCs) could be used for detecting a variety of diseases, among them gastric cancer (GC) and peptic ulcer disease (PUD). Here, we explore how geographical variation affects the disease-specific changes in the chemical composition of breath samples, as compared to control states (less severe gastric conditions). Alveolar exhaled breath samples from 260 patients were collected at two remotely different geographic locations (China and Latvia), following similar breath-collection protocols. Each cohort included 130 patients that were matched in terms of diagnosis (37 GC/32 PUD/61 controls), average ag…
The optimal imaging test for diagnosis of acute pulmonary embolism: a second chance for lung scintigraphy?
2020
Ventilation–perfusion scintigraphy may continue to be the first-line diagnostic method for pulmonary embolism in institutions that can ensure its uninterrupted availability and the expertise in its interpretationhttps://bit.ly/2y3Dlhx