Search results for "Diazoindoles"

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Synthesis and antiproliferative activity of [1,2,3,5]tetrazino[5,4-a]indoles, a new class of azolo-tetrazinones.

2004

Eight derivatives of the new ring system [1,2,3,5]tetrazino[5,4-a]indole-4-one 7, were synthesised in good yields by reaction of 2-diazoindoles with alkyl or aryl isocyanates. Compounds 7 were screened at National Cancer Institute (NCI) for their activity against a panel of approximately 60 human tumour cell lines. Some of them showed antiproliferative activity having generally GI50 in the micromolar range. The most sensitive cell lines were SF-295, SNB-75 and SF-539 of the CNS cancer sub-panel, SR of the leukaemia sub-panel, UACC-62 of the melanoma sub-panel and OVCAR-4 of the ovarian cancer sub-panel. 2004 Elsevier Ltd. All rights reserved.

MaleIndolesStereochemistryClinical BiochemistryPharmaceutical ScienceAntineoplastic AgentsBreast NeoplasmsBiochemistryChemical synthesisCentral Nervous System Neoplasmschemistry.chemical_compoundCarcinoma Non-Small-Cell LungCell Line TumorDrug DiscoverymedicineHumansMolecular BiologyMelanomaOvarian NeoplasmsLeukemiaMolecular StructureArylMelanomaOrganic ChemistryCancerDiazoindoles Azolotetrazinones Antiproliferative activity Tetrazino-indolesmedicine.diseaseIn vitroSensitive cellchemistryCell cultureColonic NeoplasmsMolecular MedicineFemaleDrug Screening Assays AntitumorOvarian cancerBioorganicmedicinal chemistry
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‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles

2014

Abstract ‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles, achieved by quenching with cold water immediately after the addition of nitrite, led, in good yields, to stable compounds whose structures were identified to be the diazonium species with nitrate as the counter ion, which show no saline character.

chemistry.chemical_classificationQuenching (fluorescence)Organic ChemistryInorganic chemistryPhotochemistryBiochemistrySettore CHIM/08 - Chimica Farmaceuticachemistry.chemical_compoundchemistryNitrateDrug DiscoveryAmino pyrroles Aminoindoles Diazoindoles Diazo pyrrolesNitriteCounterion
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