Search results for "Dichloride"
showing 10 items of 95 documents
Electrochemically reduced titanocene dichloride as a catalyst of reductive dehalogenation of organic halides
2006
Abstract We have studied a reaction between the reduced form of titanocene dichloride (Cp 2 TiCl 2 ) and a group of organic halides: benzyl derivatives (4-X C 6 H 4 CH 2 Cl, X = H, NO 2 , CH 3 ; 4-X C 6 H 4 CH 2 Br, X = H, NO 2 , PhC(O); 4-X C 6 H 4 CH 2 SCN, X = H, NO 2 ) as well as three aryl halides (4-NO 2 C 6 H 4 Hal, Hal = Cl, Br; 4-CH 3 O-C 6 H 4 Cl). It has been shown that the electrochemical reduction of Cp 2 TiCl 2 in the presence of these benzyl halides leads to a catalytic cycle resulting in the reductive dehalogenation of these organic substrates to yield mostly corresponding toluene derivatives as the main product. No dehalogenation has been observed for aryl derivatives. Base…
Syntheses and reactivity of aminobis(diorganylamino)phosphanes
1996
Aminobis(diorganylamino)phosphanes (R2N)2PNH2 (R = iPr, c-Hex, Ph) (2a–c), were obtained by treatment of the corresponding chlorobis(diorganylamino)phosphanes 1a–c with lithium amide in liquid ammonia. The transition metal phosphane complex (R2N)2(H2N)PNi(CO)3 (3) was prepared by reaction of 2a with tetracarbonylnickel. N-Complexation of 2a with trimethylalane affords the iminophosphorane-alane adduct (R2N)2HP=N(H)AlMe3 (4) by 1,2-H shift from the nitrogen to the phosphorus atom. The corresponding reaction with aluminium trichloride leads to the formation of the salt [(R2N)2HP=N(H)]2AlC12+[AlC14]− (5), in which two iminophosphorane moieties are linked by an AlCl2 bridge. Lithiation of 2a an…
Overall survival in mCPRC patients treated with Radium-223 in association with bone health agents: a national multicenter study
2020
Radium-223 has demonstrated efficacy in improving overall survival (OS) and in delaying symptomatic skeletal-related events (SREs). Bone Health Agents (BHA), i.e. RANK ligand inhibitor (Denosumab) and bisphosphonate such as zoledronic acid, are indicated to prevent SREs without a clear survival benefit. SREs on patient health have a high impact and it is, therefore, important to consider the role of new therapies with BHA to better understand the involvement of combination therapy. The primary aim of this multicentric study is to assess OS in mCRPC patients treated with Radium-223 in combination with BHA.430 consecutive patients treated with Radium-223 alone or in combination with BHA, affe…
Electrosynthesis and properties of poly(3,4-ethylenedioxythiophene) films functionalized with titanocene dichloride complex
2006
Synthesis of a titanocene dichloride derivative functionalized with 3,4-etylenedioxythiophene group, Tc1EDOT (Cl 2TiCpC5H4(CH2) (3,4ethylenedioxythiophene)) has been described. Redox behavior of the monomer in tetrahydrofuran (THF), dichloromethane (DCM) and acetonitrile (AN) at different scan rates has been discussed in terms of different ability of these solvents to coordination with the reduced titanocene (Tc) complex and the solvation of Cl − anions. Electrooxidation of Tc1EDOT to get a conducting polymer film with immobilized titanocene dichloride centers and electrochemical properties of its polymer matrix in background acetonitrile solution have been compared with those of non-substi…
Multinuclear Cytotoxic Metallodrugs: Physicochemical Characterization and Biological Properties of Novel Heteronuclear Gold-Titanium Complexes
2011
An unprecedented series of titanocene-gold bi- and trimetallic complexes of the general formula [[(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)(CH(2))(n)PPh(2))TiCl(2)](m)AuCl(x)](q+) (n = 0, 2, or 4; m = 1, x = 1, q = 0 or m = 2, x = 0, q = 1) have been prepared and characterized spectroscopically. The luminescence spectroscopy and photophysics of one of the compounds, [[(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)PPh(2))TiCl(2)](2)Au]PF(6), have been investigated in 2MeTHF solution and in the solid state at 77 and 298 K. Evidence for interfragment interactions based on the comparison of electronic band positions and emission lifetimes, namely, triplet energy transfer (ET) from the Au- to the Ti-containing…
Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties
2010
A series of bimetallic titanium-ruthenium complexes of general formula [(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)(CR(2))(n)PR'R'')TiCl(2)](η(6)-p-cymene)RuCl(2) (n = 0, 1, 2 or 4; R = H or Me; R' = H, Ph, or Cy; R'' = Ph or Cy) have been synthesized, including two novel compounds as well as two cationic derivatives of formula [(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)(CH(2))(n)PPh(2))TiCl(2)] [(η(6)-p-cymene)RuCl](BF(4)) (n = 0 or 2). The solid state structure of two of these compounds was also established by X-ray crystallography. The complexes showed a cytotoxic effect on human ovarian cancer cells and were markedly more active than their Ti or Ru monometallic analogues titanocene dichloride and RA…
Synthesis and activity of zirconocene catalysts supported on silica-type sol-gel carrier for ethylene polymerization
2001
Synthesis and activity of bis(cyclopentadienyl)zirconium dichloride catalyst supported on unconventional silica-type material obtained in sol-gel process and activated by organoaluminium co-catalyst were studied. The effect of support modification conditions (thermal dehydration and/or modification by organoaluminium compound) and a type of co-catalyst on an activity of the catalytic system in ethylene polymerization and properties of resulting polymers were investigated and compared with results obtained earlier for vanadium catalysts supported on mentioned sol-gel carrier. The most appropriate method of the sol-gel silica-type support preparation is thermal pre-treating (200°C) followed b…
Ra223 in bone metastases with osteolytic activity
2018
Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In our institution, a patient with breast cancer affected by osteolytic metastases was treated with off-label use of Ra223. The evaluation of the deposit areas of Ra223 showed a perfect overlap with the regions of osteolysis previously detected by scintigraphy, indicating a possible therapeutic effect. This case report is the first document attesting Ra223 deposit in osteolytic metastases opening new opportunity of therapeutic development…
CCDC 1053891: Experimental Crystal Structure Determination
2016
Related Article: Oana Moncea, Maria A. Gunawan, Didier Poinsot, Hélène Cattey, Jonathan Becker, Raisa I. Yurchenko, Ekaterina D. Butova, Heike Hausmann, Marina Šekutor, Andrey A. Fokin, Jean-Cyrille Hierso, Peter R. Schreiner|2016|J.Org.Chem.|81|8759|doi:10.1021/acs.joc.6b01219
CCDC 960359: Experimental Crystal Structure Determination
2014
Related Article: Pauline Désogère, Yoann Rousselin, Sophie Poty, Claire Bernhard, Christine Goze, Frédéric Boschetti, Franck Denat|2014|Eur.J.Org.Chem.|2014|7831|doi:10.1002/ejoc.201402708