Search results for "Differentiation"

University and small and medium enterprises: interdependent systems or monads? A comparison between the italian university systems and the french one

2011

The Bologna process and the Lisbona strategy showed the different national laws the organizational axes around which innovate and harmonize the various European universities. The analysis of the different national reforms of the universities show, however, that the objectives of full employment and economic competitiveness do not appear fulfilled (Charle 2007). The reforms concerned the repartition of the university studies into two cycles, the development of students mobility programs, the promotion of international cooperation programs but, rarely, the construction of a competitive knowledge (Vallauri 2004). Moving from the comparison between the recent university reform realized in Italy…

Gender differences in career plans and wage expectations of French undergraduates

2014

Gender differences in wage expectations may affect investment in human capital and increase inequalities in the labor market. Our research based on a survey of freshmen at a French university aims to understand how students form differences in wage expectations. Our results show that anticipated earnings differ significantly between men and women. One year after graduation, we find a gender pay gap of 16 per cent. A wage decomposition method indicates most of this effect is due to anticipation of discrimination. Ten years after graduation, anticipated discrimination is still almost as dominant in explaining the gender wage gap. Finally, using a survey of recent college graduates we show tha…

miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro

2012

Decidualization is a morphological and biochemical transformation of endometrial stromal fibroblast into differentiated decidual cells, which is critical for embryo implantation and pregnancy establishment. The complex regulatory networks have been elucidated at both the transcriptome and the proteome levels, however very little is known about the post-transcriptional regulation of this process. miRNAs regulate multiple physiological pathways and their de-regulation is associated with human disorders including gynaecological conditions such as endometriosis and preeclampsia. In this study we profile the miRNAs expression throughout human endometrial stromal (hESCs) decidualization and analy…

How do Wolbachia Symbionts Increase the Proportion of Females in Their Hosts?

2001

The Peculiarities of Gonad Transformation in Teleosts

1983

In teleosts the problem of sex determination and sex differentiation is more puzzling than in other vertebrates. It is not known whether the intriguing variety in the conditions of sex results from the position of these fishes within the vertebrate pedigree. They represent the final products of actinopterygian evolution toward the end of the age of reptiles, that is late in the Jurassic era. However, with that evolutionary fact in mind it is more plausible that teleosts deviate in many ways from the pattern that we are used to attribute to vertebrates in general. The following features of sex differentiation are striking examples of teleost peculiarity: (1) In both sexes there is no morphol…

Automatic differentiation of melanoma from dysplastic nevi.

2015

International audience; Malignant melanoma causes the majority of deaths related to skin cancer. Nevertheless, it is the most treatable one, depending on its early diagnosis. The early prognosis is a challenging task for both clinicians and dermatologist, due to the characteristic similarities of melanoma with other skin lesions such as dysplastic nevi. In the past decades, several computerized lesion analysis algorithms have been proposed by the research community for detection of melanoma. These algorithms mostly focus on differentiating melanoma from benign lesions and few have considered the case of melanoma against dysplastic nevi. In this paper, we consider the most challenging task a…

The colocalizations of pulp neural stem cells markers with dentin matrix protein-1, dentin sialoprotein and dentin phosphoprotein in human denticle (…

2021

Abstract Background The primary dentin, secondary dentin, and reactive tertiary dentin are formed by terminal differentiated odontoblasts, whereas atubular reparative tertiary dentin is formed by odontoblast-like cells. Odontoblast-like cells differentiate from pulpal stem cells, which express the neural stem cell markers nestin, S100β, Sox10, and P0. The denticle (pulp stone) is an unique mineralized extracellular matrix that frequently occurs in association with the neurovascular structures in the dental pulp. However, to date, the cellular origin of denticles in human dental pulp is unclear. In addition, the non-collagenous extracellular dentin matrix proteins dentin matrix protein 1 (DM…

From optimization to algorithmic differentiation: a graph detour

2021

This manuscript highlights the work of the author since he was nominated as "Chargé de Recherche" (research scientist) at Centre national de la recherche scientifique (CNRS) in 2015. In particular, the author shows a thematic and chronological evolution of his research interests:- The first part, following his post-doctoral work, is concerned with the development of new algorithms for non-smooth optimization.- The second part is the heart of his research in 2020. It is focused on the analysis of machine learning methods for graph (signal) processing.- Finally, the third and last part, oriented towards the future, is concerned with (automatic or not) differentiation of algorithms for learnin…

Parvovirus H-1-Induced Tumor Cell Death Enhances Human Immune Response In Vitro via Increased Phagocytosis, Maturation, and Cross-Presentation by Den…

2005

Oncotropic and oncolytic viruses have attracted high attention as antitumor agents because they preferentially kill cancer cells in vitro and reduce the incidence of spontaneous, induced, or implanted animal tumors. Some autonomous parvoviruses (H-1, minute virus of mice) and derived recombinant vectors are currently under preclinical evaluation. Still not fully understood, their antitumor properties involve more than just tumor cell killing. Because wild-type parvovirus-mediated tumor cell lysates (TCLs) may trigger antigen-presenting cells (APCs) to augment the host immune repertoire, we analyzed phagocytosis, maturation, and crosspresentation of H-1-induced TCLs by human dendritic cells …

Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo

2020

Abstract In Caenorhabditis elegans, the piRNA (21U RNA) pathway is required to establish proper gene regulation and an immortal germline. To achieve this, PRG‐1‐bound 21U RNAs trigger silencing mechanisms mediated by RNA‐dependent RNA polymerase (RdRP)‐synthetized 22G RNAs. This silencing can become PRG‐1‐independent and heritable over many generations, a state termed RNA‐induced epigenetic gene silencing (RNAe). How and when RNAe is established, and how it is maintained, is not known. We show that maternally provided 21U RNAs can be sufficient for triggering RNAe in embryos. Additionally, we identify PID‐2, a protein containing intrinsically disordered regions (IDRs), as a factor required …