Search results for "Diffusion"
showing 10 items of 1615 documents
Kinetics of growth process controlled by convective fluctuations
2001
A model of the spherical (compact) growth process controlled by a fluctuating local convective velocity field of the fluid particles is introduced. It is assumed that the particle velocity fluctuations are purely noisy, Gaussian, of zero mean, and of various correlations: Dirac delta, exponential, and algebraic (power law). It is shown that for a large class of the velocity fluctuations, the long-time asymptotics of the growth kinetics is universal (i.e., it does not depend on the details of the statistics of fluctuations) and displays the power-law time dependence with the classical exponent $1/2$ resembling the diffusion limited growth. For very slow decay of algebraic correlations of flu…
Mapping CO diffusion paths in Myoglobin with the Single Sweep Method
2010
The pathways of diffusion and escape of a CO molecule inside and out a myoglobin protein are investigated. Specifically, the three-dimensional potential of mean force (PMF or free energy) of the CO molecule position inside the protein is calculated by using the single-sweep method in concert with fully resolved atomistic simulations in explicit solvent.The results are interpreted under the assumption that the diffusion of the ligand can be modeled as a navigation on the PMF in which the ligand hops between the PMF local minima following the minimum free energy paths (MFEPs) with rates set by the free energy barriers that need to be crossed. We calculate all these quantities --local minima, …
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
Josephson junctions and SQUIDs based on artificial grain boundaries in Bi 2 Sr 2 Ca 2 Cu 3 O 10 -thin films
1996
ABSTRACT High quality thin films of Bi2 Sr Ca2 Cu3 0 with critical temperatures of 95 K were used to prepare grainboundary josephson junctions on commercial 36.8° SrTiOg-bicrystal substrates. IR-products of 50 pV at 77 Kand 0.7 mV at 4.2 K have been reached. For temperatures higher than 50 K the current-voltage curves of thejunctions can be well described by the resistively shunted junction (RSJ) model and show no hysteresis. Fromthe hysteretic behavior at low temperature we estimate a junction capacitance of 2ljiF/cm2. The Fraunhoferpattern of the critical current in an external applied field shows, that the junctions are inhomogeneous on a pm scale. The SQUID modulation of a 30 x 40 pm2 w…
Experimental investigation and modelling of diffusion dialysis for the recovery of waste acid solutions
2018
Pickling is widely used as a chemical pre-treatment method for cleaning metal surfaces before other surface treatments and it consumes large amount of acids and water
Experimental investigation and modelling of diffusion dialysis process for regeneration of acidic pickling solutions
2017
Pickling is one of the key steps in metal finishing industries, where HCl solutions are largely used thus generating significant amounts of spent waste solutions containing high concentrations of metals and acid. The recovery of acid from such waste solutions is thus one of the most beneficial steps for reducing the environmental and economical impact of these processes. Among several separation methods, diffusion dialysis (DD) is becoming more and more attractive thanks to the recent important advances in ion exchange membranes (IEMs) field and because of its clean nature and operational simplicity, low installation and operating costs and low energy consumption [1,2]. In the present work,…
Effective recovery of HCl and metals from pickling solutions by cutting-edge membrane technologies
2018
The pickling process is an essential step in the hot-dip galvanizing process.It is performed by immersing manufacturedsteel pieces inacid bathsin order todissolve the oxidized layers. During the pickling process, acid attacks metal oxides on the surface, dissolving them in the pickling bath. Thus, the efficiency of the pickling liquor decreases due to the accumulation of metal salts and the consumption of free acid in the solution. When hydrochloric acid is used,ferrous chloride is producedduring the pickling treatment, reaching concentrations up to 250 g/l, while the acid concentration decreases by 75-85%. A pickling bath in this condition is considered spent [1] due to thevery low picklin…
Axial dispersion model for solid flow in liquid suspension in system of two mixers in total recycle
2006
The measurement of residence time distribution of solid particles in solid-liquid suspension is experimentally difficult. However, the twin system approach is particularly suited for the assessment of particle RTD in flow systems as it allows overcoming some of the usual difficulties generally encountered in this kind of measurement. Twin system consists of two vessels and external piping in total recycle. Experimental results from this system can be evaluated using Z-transforms to derive particle RTD for subsequent testing of alternative flow models. Recently, the axial dispersion model was applied using the "advection diffusion equation" (sometimes called the"diffusion with bulk flow equa…
DC polarographic reduction of chloroguanide hydrochloride.
1984
Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3–9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism are discussed.
What’s Wrong with the Diffusion of Innovation Theory?
2001
This paper examines the usefulness of the diffusion of innovation research in developing theoretical accounts of the adoption of complex and networked IT solutions. We contrast six conjectures underlying DOI research with field data obtained from the study of the diffusion of EDI. Our analysis shows that DOI based analyses miss some important facets in the diffusion of complex technologies. We suggest that complex IT solutions should be understood as socially constructed and learning intensive artifacts, which can be adopted for varying reasons within volatile diffusion arenas. Therefore DOI researchers should carefully recognize the complex, networked, and learning intensive features of te…