Search results for "Digest"
showing 10 items of 3038 documents
Pyroglutamic Acid: A Novel Compound in Wines
2008
Wine contains a complex mixture of nearly 1,000 compounds, which include sugars, acids, alcohols, ketones, aldehydes, esters, amino acids, amines, phenol carbonic acids, flavonoids, anthocyanidins and cathechins. Many of these compounds have an influence on the aroma and bouquet of wine. Identification of wine-related compounds is by far not complete. Recently, pyroglutamic acid has been detected as a so far overlooked novel compound in wine samples, which is described below.
Malolactic fermentation in white wines
2022
Abstract Malolactic fermentation (MLF) is an important process in wine production and involves the bioconversion of malic acid into lactic acid and CO2. However, many other biochemical reactions occur simultaneously, and several other grape must and wine compounds are also modified besides malic acid. Some can improve quality, while others may be detrimental to sensory quality or health. Among them, there are the synthesis of carbonyl compounds, esters, monoterpenes, volatile phenols, acetamide or mousy odor, methanethiol, dimethyl disulfide, methionol, 3-(methylsulfanyl) propionic acid, citrulline, or biogenic amines. The role of MLF in winemaking is triple: reducing the acidity of the win…
Enological Repercussions of Non-Saccharomyces Species
2019
The bulk of the sugar fermentation in grape juice, in order to produce wine is carried out by yeasts of the genus Saccharomyces, mainly S. cerevisiae. However, S. cerevisiae is not the only wine yeast, as spontaneous grape juice fermentation involves a complex succession of growth and death of different yeasts [1,2], and each of them contribute to the organoleptic properties of the final product. Saccharomyces are not usually found in the epiphytic yeasts present on the surface of grapes, where Hanseniaspora, Candida, Pichia, and Hansenula are dominant [3]. However, Saccharomyces imposes itself due to its higher tolerance to the stressful conditions of fermentation, due to its resistance to…
Psychosocial safety climate (PSC) and enacted PSC for workplace bullying and psychological health problem reduction
2017
Bullying at work has profound effects on both the individual and organization. We aimed to determine if organizational psychosocial safety climate (PSC; a climate specific to worker psychological health) could reduce workplace bullying and associated psychological health problems (i.e., distress, emotional exhaustion, depression) if specific procedures were implemented (PSC enactment). We theorized that the PSC enactment mechanism works via psychosocial processes such as bullying mistreatment climate (anti-bullying procedures), work design (procedures reduce stress through work redesign), and conflict resolution (procedures to resolve conflict). We used two-wave national longitudinal interv…
OP0204 Autophagy and Unfolded Protein Response: A Fine Balance that can Influence the Pathogenesis of Ankylosing Spondylitis and Inflammatory Bowel D…
2015
Background We have shown an increase in the unfolded protein response (UPR) with decreased ERAP1 or ERAP2 function in an in vitro system. Similarly UPR has been demonstrated to correlate with onset of disease in the HLA-B27 rat model. UPR has been difficult to demonstrate in the gut of AS patients but autophagy is upregulated. ERAP2 is associated with both AS and inflammatory bowel disease (IBD). Objectives Here we explore the moderating effect of autophagy on UPR. Specifically we study the impact of suppressing autophagy on UPR. Methods Lamina Propria Mononuclear cells (LPMC) were isolated from terminal ileal biopsies of 10 AS patients. Autophagy was suppressed with 2 agents anisomycin and…
Electrophysiological and morphological properties of Cajal–Retzius cells with different ontogenetic origins
2010
International audience; The different origins of Cajal-Retzius cells (CRc) as well as their diverse molecular profile suggest that this cell type may represent different neuronal subpopulations. In order to investigate whether CRc from different origins show distinct functional or morphological characteristics we used transgenic Dbx1(cre);ROSA26(YFP) mice in which two subpopulations of CRc, originating from the septum and ventral pallium (VP) at the pallial-subpallial border (PSB), were permanently labeled by yellow fluorescent protein (YFP) expression. Electrophysiological properties of YFP(+) and YFP(-) CRc were investigated by whole-cell patch-clamp recordings, while a thorough somatoden…
Targeting NUPR1 with the Small Compound ZZW-115 Is an Efficient Strategy to Treat Hepatocellular Carcinoma
2020
International audience; HCC is a highly lethal malignancy with Sorafenib as the only molecularly targeted drug. The multifunctional stress-associated protein, NUPR1, plays an essential role in controlling cell growth, migration, invasion and Sorafenib resistance in HCC. We report here that NUPR1 expression is absent in healthy liver and it is progressively upregulated in HCC premalignant lesions such as hepatitis and cirrhosis with a maximum expression in HCC samples, highlighting that NUPR1 is a potential drug target for HCC. We therefore assessed in this work, ZZW-115, a strong inhibitor of NUPR1, as a promising candidate for the treatment of HCC. We validated its extraordinary antitumor …
Les peptides présents dans l'intestin chez l'homme au cours de la digestion de protéines laitières
2013
Programme prioritaire CEPIA – Devenir de l'Aliment dans le Tube Digestif -Modaltub - Animé par Didier Dupont et Isabelle Souchon; absent
Effect of onion consumption by rats on hepatic drug-metabolizing enzymes
2001
Fruits and vegetables or their natural constituents which increase detoxication enzymes and/or reduce activating enzymes are considered as good candidates to prevent chemically-induced carcinogenesis. In this study, rats were fed a diet supplemented with 20% onion powder for 9 days. Several cytochrome P450 (CYP)s enzymes (CYP 1A, 2B, 2E1, 3A), which are involved in carcinogen activation, were determined by measuring their enzyme activities using specific substrates. In addition, phase II enzymes activities such as UDP-glucuronosyltransferase (UGT) and glutathione S-transferase (GST), involved in detoxication of carcinogens, were measured. Protein levels of CYPs and GST A1/A2, A3/A5, Ml, M2 …
Que sait-on vraiment de l’impact des digestats de méthanisation sur la qualité biologique des sols agricoles ?
2020
National audience; Pas de résumé