Search results for "Digest"

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

La celiaquía en la educación obligatoria. Propuesta y evaluación de una unidad didáctica para la adquisición de competencias específicas en Salud.

2017

Desde hace algunos años se observa un interés cada vez mayor hacia los factores susceptibles de promover la salud. La realización del presente trabajo nace de la observación, como profesionales de la enseñanza, de la poca información que los estudiantes y los docentes tienen sobre las patologías relacionadas con la alimentación y en particular de la celiaquía. La celiaquía es una enfermedad autoinmnune que se caracteriza por una inflamación crónica de la de la parte próxima del intestino delgado causada por la exposición a la gliadina, que es uno de los componentes del gluten (proteína presente en el trigo, la cebada, el centeno, el triticale, el kamut, la espelta y posiblemente la avena). …

New Insights Into Causal Pathways Between the Pediatric Age-Related Physical Activity Decline and Loss of Control Eating: A Narrative Review and Prop…

2020

Research consistently suggests that loss of control (LOC) eating in children and adolescents is a key factor contributing to pediatric obesity and eating disorders. However, causes of pediatric LOC eating are yet unclear, and there is a lack of longitudinal research investigating the developmental processes contributing to LOC eating and related outcomes in youth. Physical activity is an understudied behavior that declines during middle childhood to adolescence and may exert an influence in the development of LOC eating via its impact on executive functioning. While physical activity levels and executive functioning have been linked to regulation of eating, no research has examined the mech…

Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis

2022

Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…

Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment

2022

Hypertension is a leading risk factor for cardiovascular diseases and can reduce life expectancy. Owing to the widespread use of antihypertensive drugs, patients with hypertension have improved blood pressure control over the past few decades. However, for a considerable part of the population, these drugs still cannot significantly improve their symptoms. In order to explore the reasons behind, pharmacomicrobiomics provide unique insights into the drug treatment of hypertension by investigating the effect of bidirectional interaction between gut microbiota and antihypertensive drugs. This review discusses the relationship between antihypertensive drugs and the gut microbiome, including cha…

Emigrazione e immigrazione

2013

Aggiornamento della voce enciclopedica "Emigrazione e immigrazione" di Giovanni Kojanec (1990)

The Effect of Mechanocatalytic Pretreatment on the Structure and Depolymerization of Willow

2020

In this study, the effect of a mechanocatalytic pretreatment on the structure of willow and sugar release from pretreated willow was explored. In the mechanocatalytic approach, the pretreatment consists of solvent-free impregnation with sulfuric acid and a mechanical treatment with ball milling. Willow sawdust and pretreated samples were analyzed with field emission scanning electron microscope and X-ray diffraction. The products in the sugar solution were determined as the total reducing sugars with the 3,5-dinitrosalicylic acid method and monosaccharides with capillary electrophoresis. According to the results, milling increased the sugar production, depending on the sulfuric acid load. T…

Thermophilic anaerobic digestion of source separated institutional food waste and kitchen waste

2013

Measuring Vulnerability in the Food System

2015

Food system vulnerability is an emerging concept for food security policies and food supply chain management. Hence, measuring food system vulnerability is necessary for developing appropriate food security policies and managing food supply chain vulnerabilities. In this paper, we aim to clarify the development process of food system vulnerability indicators. We conducted an abducted qualitative content analysis based on public documents of various Finnish organizations, including ministries and administration, interest organizations, NGOs, food sector enterprises, and a church. We analysed the engagement level of various organizations in food security and identified vulnerability aspects i…

Human saliva, taste and food perception

2011

Human saliva, taste and food perception