Search results for "Dino"
showing 10 items of 490 documents
Two in one against motor neuron degeneration: tackling oxidative stress and inflammation with a sulfasalazine derivative.
2012
Liberty winter gardens in Palermo: contamination from solar design
2020
At the end of the 19th century, the city of Palermo boasted a tradition of steel elements that could include the most beautiful railings and light steel structures of the time. The paper shows how the technological, formal and spatial aspects of the metallic construction was derived by the application of Central Europe areas examples to the local reality, providing notions on designs, experimentations and originalities. Canopies, verandas, winter gardens and orangeries are architectural elements in iron and glass that represent an added value for the building, they improve the life quality of the people who live there. In particular, in the Liberty architecture these elements took shape thr…
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
Il dono del tiranno. Gelone e il “corno di Amaltea” a Ipponio
2016
L’articolo riprende in esame una testimonianza piuttosto problematica di Duride di Samo, trasmessa da Ateneo, in cui si narra della creazione da parte di Gelone, tiranno dei Siracusani all’inizio del V sec. a.C., di un luogo chiamato “corno di Amaltea”, in bosco nei pressi di Ipponio. A partire dall’analisi del contesto in cui la testimonianza ricorre, nei Deipnosofisti, e dal confronto con le fonti relative alla figura di Amaltea e ai luoghi così denominati nell’antichità, il contributo si propone di suggerire una chiave di lettura per questo episodio che marca gli esordi della politica dei Dinomenidi al di là dello Stretto. This paper examines Douris of Samos’ quite problematic testimony,…
L’acqua tra natura e artificio nella cultura del giardino europeo dei secoli XVIII e XIX, dal Landscape garden al Picturesque garden
2010
L’acqua, protagonista del giardino sin dalle sue origini, nella storia del giardino e del paesaggio, ha da sempre rivestito un ruolo fondamentale sia per il suo valore scenografico che per il suo valore altamente simbolico. A partire dalla prima metà del XVIII, con il tramontare del giardino formale, cui si sostituisce il giardino paesistico di origine anglosassone, l’acqua resta una componente fondamentale all’interno della progettazione dei giardini, ma assume un ruolo diverso: messe al bando le forme regolari e le rigide simmetrie, con la nascita del giardino paesistico l’acqua è «disegnata» in forme libere e, trasformandosi in lago o stagno, sembra voler riacquistare la sua forma origin…
La grotta come evocazione della divinità femminile nei giardini siciliani
2021
This essay looks at how garden grottos a in Europe have been defined and classified through the centuries to understand how they reveal the changing relationship between man and “other”. Made from ephemeral material and subject to high levels of humidity, grottos are particularly vulnerable cultural artefacts. Despite having a rich history of ornamental grottos, up until now little attention has been paid to the grottos of Sicily. Thus, an initial list of eight specifically Sicilian grotto types is offered, in the hopes of inspiring interest in their history and conservation.
Consensus guidelines for the detection of immunogenic cell death
2014
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defect…
2020
This study aimed to explore the acute effects of static stretching on the musculotendinous properties of two hamstring muscles. Twelve male volunteers underwent two testing sessions. One session was dedicated to the evaluation of the semitendinosus muscle before (PRE) and after (POST) static stretching (five sets of 30-s stretching), and the other session similarly explored the long head of biceps femoris muscle. In addition to the displacement of the myotendinous junction (MTJ), passive torque and maximal voluntary isometric torque (MVIT) were evaluated. MVIT (−8.3 ± 10.2%, p = 0.0036, d = 0.497) and passive torque (−28.4 ± 16.9%, p = 0.0003, d = 1.017) were significantly decreased POST st…
A Versatile Approach to CF3-Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1…
2015
The synthesis of new fluorinated pyrrolidones starting from unprotected amino esters and amino nitriles through a Michael addition-lactamization sequence is described. The resulting CF3 -containing building blocks, bearing a quaternary stereogenic center adjacent to the fluorinated group, have been converted into amino pyrrolidines that display potent β-secretase 1 (BACE1) inhibitory activity. This work constitutes an example of selective fluorination as a valid strategy for the modulation of physicochemical and biological properties of lead compounds in drug discovery.
Inhibition of imidazolidinone intermediate formation in the aldol reactions catalyzed by zinc–prolinamide complexes
2011
Abstract The use of zinc salts as cocatalysts in aldol condensations catalyzed by single prolinamide (and in the extension by other more complex prolinamides) can prevent the formation of the parasitic intermediate imidazolidinone, with faster and also more stereoselective reactions than those catalyzed by the free amine. This new finding, together with this ion’s already known properties, make zinc salts highly suitable additives for aldol reactions catalyzed for prolinamide derivatives.