Search results for "Dino"
showing 10 items of 490 documents
Liver X Receptor Regulates Arachidonic Acid Distribution and Eicosanoid Release in Human Macrophages
2013
Objective— Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are highly expressed in macrophages and regulate lipid homeostasis and inflammation. Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at the sn-2 position of glycerophospholipids and, therefore, the availability of fatty acids, such as arachidonic acid (AA), used for eicosanoid synthesis. The aim of our study was to determine whether LXRs could regulate the Lands cycle in human macrophages, to assess the consequences in terms of lipid composition and inflammatory response, and to work out the relative contribut…
Dinotrema cavernicola sp. n. (Hymenoptera, Braconidae, Alysiinae), a new species of the genus Dinotrema Foerster from caves of Spain
2014
Dinotrema cavernicola sp. n. was collected in two caves in Spain. This is the first Dinotrema species known to occur in caves. This new species is described and compared to D. affine (Fischer, 1973) and D. collybiae Munk & Peris-Felipo, 2014, species sharing a mid-longitudinal carina on the propodeum.
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signali…
2002
Abstract Among the anti-neutrophil cytoplasmic Abs (ANCA), those targeting proteinase 3 (PR3) have a high sensitivity and specificity for Wegener’s granulomatosis (WG). A pathogenetic role for these autoantibodies has been proposed due to their capacity of activating neutrophils in vitro. Recently, PR3 was also detected in human renal tubular epithelial cells (TEC). In the present study, the effect of murine monoclonal anti-PR3 Abs (anti-PR3) and purified c-ANCA targeting PR3 from WG serum on isolated human renal tubular cell signaling and inflammatory mediator release was characterized. Priming of TEC with TNF-α resulted in surface expression of PR3, as quantified in immunofluorescence stu…
Jo Nesbø’s The Snowman and the Myth of Týr: Addressing Contemporary Issues through Literary Tradition
2018
Il saggio esplora il modo in cui l'autore di Scandi-noir Jo Nesbø rifunzionalizza il mito norreno del dio germanico Týr (e anche alcuni altri episodi mitologici) nel suo popolare romanzo The Snowman (2007). Nesbø adatta questi miti medievali per creare situazioni ed enigmi allusivi e sfrutta il gioco intellettuale del medievalismo per creare un significato semanticamente denso. Il romanzo quindi esplora e considera varie questioni contemporanee tra cui, per esempio, il valore della “verità” rispetto alla percezione individuale (e contestuale), la supposta dicotomia tra vittima e carnefice, e il conflitto tra individuo e società. L'analisi dimostra non solo la densità semantica di The Snowma…
Potential Antipsoriatic Avarol Derivatives as Antioxidants and Inhibitors of PGE2 Generation and Proliferation in the HaCaT Cell Line
2004
The synthesis and structure-activity relationships for a series of 14 new avarol derivatives as antioxidants and inhibitors of cell proliferation and PGE(2) generation in human keratinocytes are described. Compound 6 (thiosalicylic derivative) was the most potent inhibitor of superoxide generation in human neutrophils and also potently inhibited PGE(2) generation in the human keratinocyte HaCaT cell line. Compound 7(3'-methylaminoavarone) presented the best antiproliferative profile, by the inhibition of (3)H-thymidine incorporation in HaCaT cells, with potency similar to the reference compound anthralin. None of the avarol derivatives showed any sign of cytotoxicity measured as LDH release…
Zvaigžņotā Debess: 2001, Rudens (173)
2001
Contents: G.Ozoliņš. Radio-Locators Investigate Solar System ; U.Dzērvītis. First Radio Star Discovered ; J.Āboliņš. Science, Dinosaurs and Evolution: Cosmos and Life on Earth ; Z.Alksne, A.Alksnis. Our Galaxy Swallows Its Companions ; A.Balklavs. New Data on Massive Objects in the Galactic Cores ; A.Balklavs. Actualities of Investigations of Dwarf Galaxies ; Z.Alksne. The Web of the Early Universe Primordial Filaments ; M.Gertāns. NEAR Mission Successfully Completed ; I.Vilks. Spaceflight. Almost Everyday Life (1973-2000) (concluded) ; J.Jaunbergs, D.Meldere. Mr. Tito’s Great Space Adventure ; N.Cimahoviča, A.Balklavs. Radio Astronomy in Latvia. How It All Happened ; J.Jansons. First Unive…
Suitability of Phytosterols Alongside Fatty Acids as Chemotaxonomic Biomarkers for Phytoplankton
2016
The composition and abundance of phytoplankton is an important factor defining ecological status of marine and freshwater ecosystems. Chemotaxonomic markers (e.g., pigments and fatty acids) are needed for monitoring changes in a phytoplankton community and to know the nutritional quality of seston for herbivorous zooplankton. Here we investigated the suitability of sterols along with fatty acids as chemotaxonomic markers using multivariate statistics, by analyzing the sterol and fatty acid composition of 10 different phytoplankton classes including altogether 37 strains isolated from freshwater lakes. We were able to detect a total of 47 fatty acids and 29 sterols in our phytoplankton sampl…
Un labirinto del tardo Quattrocento nel giardino di Giovan Tomaso Moncada
2017
Da un manoscritto databile intorno al 1550 e un saggio a stampa sulle feste reali celebrate a Palermo, pubblicato nel 1703, sappiamo dell'esistenza di un labirinto nel giardino dell'aristocratico Giovan Tomaso Moncada, costruito negli anni settanta o negli anni ottanta del XV secolo nella campagna vicino Palermo. Si tratta della scena in cui ebbe luogo un ricco banchetto offerto al Viceré Ferdinando de Acuña. Secondo l'autore del manoscritto, Gian Giacomo Adria, modello di riferimento per il labirinto siciliano era quello cretese del Minotauro e lo stesso aveva forma quadrata, con otto circuiti, circondato da un muro decorato con un motivo a chiavi spezzate. Sebbene non abbiamo elementi suf…
Enantioselective Henry addition of methyl 4-nitrobutyrate to aldehydes. Chiral building blocks for 2-pyrrolidinones and other derivatives.
2010
A catalytic highly enantioselective Henry addition of methyl 4-nitrobutyrate to aldehydes using a Cu(II)-amino pyridine complex as catalyst is described. The products resulting from this reaction constitute a new, highly versatile family of chiral building blocks as a result of the presence of three different functional groups on the molecule. These products have been transformed into nonracemic chiral gamma-lactams, 5-hydroxy-5-substituted levulinic acid derivatives, and delta-lactones.
Il ladino e i suoi idiomi
2020
In questo capitolo si illustrano le suddivisioni interne al gruppo ladino. Dopo aver sottolineato la posizione particolare dell’ampezzano (appartenente linguisticamente al gruppo cadorino), si mostra che le restanti varietà sono separate da tre diverse linee di demarcazione che si sovrappongono: una linea di origine altomedievale che corre da nord a sud, dividendo Fassa e Gardena da Badia e Fodom; una da ovest a est, più recente, che isola il ladino settentrionale (valli di Gardena e Badia) dal ladino meridionale; e infine una linea circolare che separa le varietà centrali da quelle periferiche.Nella seconda parte del capitolo sono discusse le differenze fonologiche, morfologiche, sintattic…