Search results for "Direct"
showing 10 items of 2669 documents
The Fumarate/Succinate Antiporter DcuB of Escherichia coli Is a Bifunctional Protein with Sites for Regulation of DcuS-dependent Gene Expression
2008
DcuB of Escherichia coli catalyzes C4-dicarboxylate/succinate antiport during growth by fumarate respiration. The expression of genes of fumarate respiration, including the genes for DcuB (dcuB) and fumarate reductase (frdABCD) is transcriptionally activated by C4-dicarboxylates via the DcuS-DcuR two-component system, comprising the sensor kinase DcuS, which contains a periplasmic sensing domain for C4-dicarboxylates. Deletion or inactivation of dcuB caused constitutive expression of DcuS-regulated genes in the absence of C4-dicarboxylates. The effect was specific for DcuB and not observed after inactivation of the homologous DcuA or the more distantly related DcuC transporter. Random and s…
INTRODUZIONE AL D.LGS. 19 GENNAIO 2017, N. 3, DI ATTUAZIONE DELLA DIR. 2014/104/UE SUL RISARCIMENTO DEI DANNI PER VIOLAZIONE DELLA NORMATIVA ANTITRUST
2018
Con l’emanazione del d.lgs. 19 gennaio 2017, n. 3 e` stata data attuazione alla direttiva 2014/104/UE del Parlamento e del Consiglio del 26 novembre 2014, relativa a determinate norme che regolano le azioni per il risarcimento del danno ai sensi del diritto nazionale per violazioni delle disposizioni del diritto della concorrenza degli Stati membri e dell’Unione europea. Lo scritto, nell'introdurre una serie di commenti alla neo-introdotta normativa, esamina il percorso evolutivo che ha condotto all'emanazione della direttiva, le scelte con essa operate e le modalità di recepimento nell'ordinamento italiano. With the issuance of Legislative Decree January 19, 2017, no. 3 was implemented the…
The HCV Sicily Network: A web-based model for the management of HCV chronic liver diseases
2016
Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment.The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis. The network includes 41 centers and 84 gastroenterologists or infectivologists connected by a web platform that recorder the diagnosis and the clinic priority for the…
Foreign Direct Investment in oil-abundant countries: The role of institutions
2019
The present work reassesses the impact of good governance and democracy on Foreign Direct Investment (FDI) in oil-abundant countries. To this end, we estimate the effect of host countries’ institutions on greenfield FDI, using a gravity equation for a dataset that covers 182 countries during 2003-2012. Our findings confirm that compliance to rule of law, lack of corruption, political stability and democracy could boost new FDI links through the extensive margin. Our results could not rule out the “oil curse”, meaning that oil producers attract fewer new greenfield projects than similar countries without oil. Unlike other studies, we show that the impact of institutions is not necessarily un…
Hölder stability for Serrin’s overdetermined problem
2015
In a bounded domain \(\varOmega \), we consider a positive solution of the problem \(\Delta u+f(u)=0\) in \(\varOmega \), \(u=0\) on \(\partial \varOmega \), where \(f:\mathbb {R}\rightarrow \mathbb {R}\) is a locally Lipschitz continuous function. Under sufficient conditions on \(\varOmega \) (for instance, if \(\varOmega \) is convex), we show that \(\partial \varOmega \) is contained in a spherical annulus of radii \(r_i 0\) and \(\tau \in (0,1]\). Here, \([u_\nu ]_{\partial \varOmega }\) is the Lipschitz seminorm on \(\partial \varOmega \) of the normal derivative of u. This result improves to Holder stability the logarithmic estimate obtained in Aftalion et al. (Adv Differ Equ 4:907–93…
Nonlocal elasticity and related variational principles
2001
Abstract The Eringen model of nonlocal elasticity is considered and its implications in solid mechanics studied. The model is refined by assuming an attenuation function depending on the `geodetical distance' between material particles, such that in the diffusion processes of the nonlocality effects certain obstacles as holes or cracks existing in the domain can be circumvented. A suitable thermodynamic framework with nonlocality is also envisaged as a firm basis of the model. The nonlocal elasticity boundary-value problem for infinitesimal displacements and quasi-static loads is addressed and the conditions for the solution uniqueness are established. Three variational principles, nonlocal…
A new force field including charge directionality for TMAO in aqueous solution
2016
We propose a new force field for trimethylamine N-oxide (TMAO), which is designed to reproduce the long-lived and highly directional hydrogen bond between the TMAO oxygen (OTMAO) atom and surrounding water molecules. Based on the data obtained by ab initio molecular dynamics simulations, we introduce three dummy sites around OTMAO to mimic the OTMAO lone pairs and we migrate the negative charge on the OTMAO to the dummy sites. The force field model developed here improves both structural and dynamical properties of aqueous TMAO solutions. Moreover, it reproduces the experimentally observed dependence of viscosity upon increasing TMAO concentration quantitatively. The simple procedure of the…
Modes of motion in a confined colloidal suspension under shear
2004
We investigated aqueous suspensions of charged polystyrene latex spheres at low salt concentration under the combined influence of steady shear and confining walls. Their equilibrium structure was adjusted via the particle and salt concentration to be either fluid or body centred cubic. Using high-resolution real-space microscopy, we here present a first direct observation of collective modes of motion under shear. As a function of either shear rate and/or salt concentration, we find a continuous transition from registered to free sliding of layers accompanied by an equally continuous structural rearrangement lowering the dimensionality of long-ranged order.
L'assureur peut-il opposer à la victime, qui exerce l'action directe contre l'assureur de l'auteur du dommage, la clause compromissoire contenue dans…
2022
(Versailles 21 janv. 2021, no 19/02675, SAS Rohlig France c/ Sté Vincy Construction Grands Projet, Rev. arb. 2021. 844, note J. Billemont)
La soumission de l'arbitrage international à un régime protecteur du consommateur
2021
International audience; (Civ. 1re, 30 septembre 2020, n° 18-19.241, D. 2020. 2501, note D. Mouralis ; ibid. 2484, obs. T. Clay ; AJ contrat 2020. 485, obs. D. Mainguy ; RTD civ. 2020. 845, obs. L. Usunier ; Dalloz actualités, 19 octobre 2020, 1949, obs. J. Jourdan-Marques ; JCP 2020, 311, note M. de Fontmichel ; JDI 2020. 1307, note E. Gaillard)