Search results for "Disaccharide"

showing 3 items of 43 documents

Anti-Inflammatory Activity of Flavonol Glycosides fromErythrospermum monticolumDepending on Single or Repeated Local TPA Administration

1995

Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.

medicine.drug_classFlavonoidPharmaceutical SciencePharmacologyPharmacognosyDisaccharidesAnti-inflammatoryAnalytical Chemistrylaw.inventionMicechemistry.chemical_compoundFlacourtiaceaelawDrug DiscoverymedicineAnimalsEdemaBioassayheterocyclic compoundsPharmacologychemistry.chemical_classificationbiologyAnti-Inflammatory Agents Non-SteroidalOrganic ChemistryGlycosidebiology.organism_classificationComplementary and alternative medicinechemistryBiochemistryTetradecanoylphorbol AcetateMolecular MedicineFemaleQuercetinPhytotherapyQuercetinPlanta Medica
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The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule.

1990

The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c mice with MCF-7 breast tumor cells together with synthetic Gal-GalNAc linked to a BSA carrier. One monoclonal antibody (82-A6) was established which recognizes the Thomsen-Friedenreich antigen according to the biochemical and serological analysis presented here. In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhib…

medicine.drug_classHealth Toxicology and MutagenesisDisaccharidesMonoclonal antibodyMalignancyAntibodiesEpitopeAntigenAntibody SpecificityAntigens NeoplasmTumor Cells CulturedmedicineHumansAntigens Tumor-Associated Carbohydratechemistry.chemical_classificationMolecular StructurebiologyThomsen-Friedenreich AntigenPublic Health Environmental and Occupational Healthmedicine.diseaseMolecular biologyMolecular Weightcarbohydrates (lipids)chemistrybiology.proteinImmunohistochemistryAntibodyCarrier ProteinsGlycoproteinResearch ArticleEnvironmental Health Perspectives
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The toxic and lethal effects of the trehalase inhibitor trehazolin in locusts are caused by hypoglycaemia

2003

SUMMARY The main blood sugar of locusts is trehalose, which is hydrolysed to two glucose units by trehalase. Homogenates of locust flight muscles are rich in trehalase activity, which is bound to membranes. A minor fraction of trehalase is in an overt form while the remainder is latent, i.e. active only after impairing membrane integrity. Trehazolin, an antibiotic pseudosaccharide,inhibits locust flight muscle trehalase with apparent Ki-and EC50 values of 10–8 mol l–1and 10–7 mol l–1, respectively. Trehazolin is insecticidal: 50 μg injected into locusts completely and selectively blocked the overt form of muscle trehalase (with little effect on latent activity) and killed 50% of the insects…

medicine.medical_specialtyanimal structuresPhysiologyTrehalase activityBlood sugarGrasshoppersIn Vitro TechniquesAquatic ScienceBiologyCarbohydrate metabolismDisaccharideschemistry.chemical_compoundInternal medicineHemolymphmedicineAnimalsTrehalaseTrehalaseMolecular BiologyEcology Evolution Behavior and SystematicsLethal dosebiology.organism_classificationTrehaloseGlucoseEndocrinologyBiochemistrychemistryFlight AnimalInsect ScienceAnimal Science and ZoologyLocustJournal of Experimental Biology
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