Search results for "Disc"
showing 10 items of 19256 documents
Expression of emotion through musical parameters in 3- and 5-year-olds
2019
While the use of musical parameters for emotional expression has been extensively studied, little is known about which specific musical parameters children at different ages are able to use for expressing specific emotions. We used a novel interface called Music Box that allows modification of musical parameters while music is being played in real time. Children (N = 37, 18 girls) at the age of 3 and 5 were asked to modify three parameters – tempo, loudness, and pitch – in expressing three emotions – happiness, sadness, and anger. We hypothesised that both 5-year-olds and 3-year-olds could use each of the parameters in differentiating between the emotions. Results showed that 3-year-olds we…
Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study
2014
[Abstract.] Music is a highly complex and versatile stimulus for the brain that engages many temporal, frontal, parietal, cerebellar, and subcortical areas involved in auditory, cognitive, emotional, and motor processing. Regular musical activities have been shown to effectively enhance the structure and function of many brain areas, making music a potential tool also in neuro- logical rehabilitation. In our previous randomized controlled study, we found that listening to music on a daily basis can improve cognitive recovery and improve mood after an acute mid- dle cerebral artery stroke. Extending this study, a voxel-based morphometry (VBM) analysis utilizing cost function masking was perf…
Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines
2012
Reaction of enaminones 1a–d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2) in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a–d. On the other hand, 2-aminopyrano[4,3,2-de] [1,6]naphthyridine-3-carbonitriles 20a–c,e were the only obtained products from the reactions of 1a–d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl)-phenyl]-(4-chloro-phenyl)-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid eth…
New tricyclic systems as photosensitizers towards triple negative breast cancer cells.
2022
AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The mos…
New Tripentone Analogs with Antiproliferative Activity
2017
Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) and MCF-7 (human breast cancer). The most active derivative, with GI50 values of 4.25 µM and 20.73 µM for HCT-116 a…
Orden del imperio, discurso televisivo y memoria: “narco-series” y construcción de la realidad en la sociedad colombiana del siglo XXI
2017
La investigación se pregunta por las formas como se construye el discurso de la serie televisiva Escobar, el patrón del mal y los posibles efectos que tiene sobre la memoria colectiva colombiana. No se trata de desvelar sentidos ocultos o de explicar el significado del discurso televisivo. Se trata de estudiar cómo se produce el pasado en un relato de ficción; cuáles son las circunstancias sociales, económicas, históricas y políticas de dicha producción; y cómo se articulan discurso televisivo, guerra y memoria en la biopolítica del Imperio propuesta por Hardt y Negri (2002). Para ello, se hizo análisis crítico del discurso a la luz de un corpus teórico interdisciplinar que bebe de la semió…
Up-to-date Spanish continental Neogene synthesis and paleoclimatic interpretation
1993
A synthesis of the Spanish continental Neogene is presented by designing an integrated correlative chart of the Neo" gen-e "succes"Siuns-ofthe "lberian-PeninsuIa-. -Ninemain-sedimentary-breaks-have-been -distinguished-in-most-of-the "basins. They are considered a valuable criteria for correlation as they occur in similar time intervals from basin to basin. The determined sedimentary breaks occur in the Agenian, Ramblian, Middle Aragonian, Late Aragonian, Late Vallesian, Middle Turolian, Late Turolian, Late Ruscinian-Early Villafranchian, and Villafranchian ages. The larger interior basins (Ebro, Tajo, Duero) show a fairly complete Neogene sedimentary record in which the aboye mentioned sedi…
Hiperrespuesta bronquial y marcadores de inflamación en aire exhalado en pacientes con discinesia ciliar primaria
2015
La discinesia ciliar primaria (DCP) es una enfermedad genética, de herencia autosómica recesiva, de baja prevalencia (aproximadamente 1/20.000). Se caracteriza por una alteración de la ultraestructura ciliar y/o disfunción de la movilidad de los cilios, produciéndose una disminución del aclaramiento mucociliar y estasis de secreciones. Sus manifestaciones clínicas comienzan en la infancia y afectan fundamentalmente al aparato respiratorio, siendo prácticamente constante la aparición de bronquiectasias, que son las que marcan el pronóstico de los pacientes. La hiperrespuesta bronquial (HRB) se ha postulado como un factor de riesgo que podría acelerar la aparición de éstas al disminuir todaví…
El concepto de discapacitado y su protección patrimonial.
2013
El concepto de discapacitado es analizado desde diferentes ámbitos tanto desde las perspectivas: doctrinales, en las normativas del Derecho Internacional, el Derecho de la Unión Europea, el Derecho Español y su jurisprudencia, en este último se centra su estudio en el grado discapacidad, por lo que se estudia la declaración de la persona con discapacidad. Una vez aclaradas que personas son discapacitadas, se inicia el estudio de los efectos jurídicos que conlleva a la persona con discapacidad para ser beneficiaria del patrimonio protegido. Inmediatamente, el estudio profundiza que finalidad tiene el patrimonio protegido en la persona con discapacidad, conllevando el estudio de sus caracterí…
Pandataria: una mirada feminista al derecho internacional de los derechos humanos y al derecho internacional de las personas refugiadas
2014
Poner de manifiesto el sesgo androcéntrico del Derecho Internacional de los Derechos Humanos y ver cómo este sesgo se reproduce en el Derecho Internacional de las Personas Refugiadas para evidenciar cómo las mujeres son discriminadas. Tras evidenciar este sesgo androcéntrico en estas dos ramas del Derecho se procede a la reconceptualización de conceptos fundamentales del Derecho Internacional de los Derechos Humanos y del Derecho Internacional de las Personas Refugiadas para que éstos sean más inclusivos y facilitar el reconocimiento de las violaciones de derechos de las mujeres como violaciones de derechos humanos y como persecución o tortura para facilitar su reconocimiento como refugiada…