Search results for "Disc"
showing 10 items of 19256 documents
Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors
2023
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, and 41 were chosen for the synthesis based on the results of the in silico screening. Each of the synthesized compounds was tested for its in vitro antibacterial and antifungal activities using a variety of strains. All the compounds showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus pyogenes) as well as Gram-negativ…
Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor.
2022
A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed and synthesized to explore more potent natural product-derived antitumor agents. The structures of the target compounds were confirmed by FTIR, NMR, and HRMS. The in vitro antitumor activity was tested by standard methyl thiazolytetrazolium assay and showed that 4i, 4g, 4s, and 4m are the best compounds with IC50 values of 6.04 ± 0.62µM, 3.21 ± 0.67µM, 19.09 ± 0.49µM, and 18.68 ± 1.53µM, against Hela, MGC-803, MCF-7, and A549, respectively. The results of the preliminary action mechanism studies showed that compound 4i, the representative compound, could induce cell apoptosis in Hela cells in a dose-dep…
Longitudinal associations between teacher-child interactions and academic skills in elementary school
2017
This study examined the extent to which the quality of teacher-child interactions assessed in kindergarten (6-year-olds) is associated with children's reading and math development across the elementary school years. The sample consisted of 515 Finnish children (271 boys, 244 girls). Teacher-child interactions were observed in 49 kindergarten classrooms. The findings from the latent growth curve models showed that high-quality teacher–child interactions in kindergarten were positively associated with the initial levels of reading and math skills. Furthermore, the results indicated that high-quality teacher-child interactions in kindergarten were positively associated with children's academic…
Intrusion detection applications using knowledge discovery and data mining
2014
Causality-Aware Convolutional Neural Networks for Advanced Image Classification and Generation
2023
Smart manufacturing uses emerging deep learning models, and particularly Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs), for different industrial diagnostics tasks, e.g., classification, detection, recognition, prediction, synthetic data generation, security, etc., on the basis of image data. In spite of being efficient for these objectives, the majority of current deep learning models lack interpretability and explainability. They can discover features hidden within input data together with their mutual co-occurrence. However, they are weak at discovering and making explicit hidden causalities between the features, which could be the reason behind the parti…
Tiesneša atbildība kā līdzeklis taisnīguma nodrošināšanai
2020
Tā kā tiesa ir vienīgā institūcija, kurai ir tiesības spriest tiesu, tiesnesis ir tas, kurš nes atbildību par to, lai lietas dalībnieki nonāktu pie taisnīga lietas iznākuma. Personai ir tiesības uz lietas likumīgu izskatīšanu, ko nodrošina tieši tiesa (tiesnesis) un gadījumā, ja tas netiek nodrošināts tiesnesim iestājas atbildība un viņa rīcība tiek vērtēta. Gan pildot amata pienākumus, gan arī ārpus darba tiesnesim ir jāievēro likumā paredzētās normas un tiesneša ētika. Spriežot tiesu tiesnesim nedrīkst būt savas intereses un viņš ir pakļauts vienīgi likumam. Pieļauta pārkāpuma gadījumā, tiesnesim jānes atbildība par savu rīcību, un viņš nav no tās atbrīvots. Maģistra darba temats ir “Ties…
The Case Study in Family Business : An Analysis of Current Research Practices and Recommendations
2016
In this study, we identified and analyzed 75 articles in the family business (FB) literature between 2000 and 2014 as to the case study design they adopted. We found that the positivistic case study approach is the FB disciplinary convention. The two alternative approaches of critical realism and interpretivism are used to a significantly lesser extent. We anticipate that in the future the positivistic approach will continue to be used widely. The other two approaches can be employed to a higher extent since their use is likely to contribute to a scientific pluralism in FB case study research.
ELECTRICAL DISCHARGE MACHINING - A HIGH FUTURE NONCONVENTIONAL PROCESSING PROCESS
2021
Electrical discharge machining is one of the most common processes for processing metallic materials. This process is characterized by the lack of mechanical pressure on the object that ensures the macroscopic location of the erosive agent. This scientific paper highlights a study based on experimental data processing as well as modeling the most important technological parameters for dimensional processing by electrical discharge machining with and without magnetic activation. In this context, the modeling and optimization of process parameters is approached, which can lead to the quality increasing of the processed surface, to an increase of the processing productivity and to a reduction …
Models of group-buying in competitive markets
2008
Quantum Correlation Dynamics in Controlled Two-Coupled-Qubit Systems
2020
We study and compare the time evolutions of concurrence and quantum discord in a driven system of two interacting qubits prepared in a generic Werner state. The corresponding quantum dynamics is exactly treated and manifests the appearance and disappearance of entanglement. Our analytical treatment transparently unveils the physical reasons for the occurrence of such a phenomenon, relating it to the dynamical invariance of the X structure of the initial state. The quantum correlations which asymptotically emerge in the system are investigated in detail in terms of the time evolution of the fidelity of the initial Werner state.