Search results for "Dofetilide"

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Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study

2010

[EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneit…

Drugtherapy planningCardiac electrophysiologyHeart rhythm disordersComputer sciencemedia_common.quotation_subjectComputer Science (all)Cardiac electrophysiologyDofetilide3d modelmulti-scale modelingsimulationdrug cardio-toxicityTheoretical Computer ScienceTECNOLOGIA ELECTRONICAdrug modelingCardiac electrophysiology; drug cardio-toxicity; drug modeling; multi-scale modeling; simulation; therapy planning; Computer Science (all); Theoretical Computer SciencemedicineHeart beatAction potential durationNeurosciencemedicine.drugmedia_common
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Dofetilide effects on the inhibition by trains of subthreshold conditioning stimuli.

2004

We investigated the electrophysiological actions of dofetilide upon the ventricular myocardium to determine whether the drug modifies the inhibitory effects of subthreshold stimuli trains upon ventricular refractoriness. In nine Langendorff perfused rabbit hearts, ventricular epicardial electrodes were used to determine the following parameters at baseline and during dofetilide perfusion (0.5 micromolar): effective (ERP) and functional (FRP) refractory periods, conduction velocity (CV), wavelength (WL), and ERP prolongation (inhibitory effect) induced by subthreshold stimuli trains (STr) at pulse frequencies of 100, 300, and 600 Hz. Dofetilide significantly prolongs ventricular refractorine…

medicine.medical_specialtyCardiac Complexes PrematureRefractory Period ElectrophysiologicalHeart VentriclesDofetilideStimulationInhibitory postsynaptic potentialNerve conduction velocityElectrocardiographyHeart Conduction SystemInternal medicinePhenethylaminesmedicinePotassium Channel BlockersAnimalsSulfonamidesDose-Response Relationship DrugSubthreshold conductionPulse (signal processing)business.industryCardiac Pacing ArtificialGeneral MedicineElectric StimulationElectrophysiologyAnesthesiaModels AnimalCardiologyRabbitsCardiology and Cardiovascular MedicinebusinessPerfusionAnti-Arrhythmia Agentsmedicine.drugPacing and clinical electrophysiology : PACE
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