6533b825fe1ef96bd128286b
RESEARCH PRODUCT
Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study
Elvio HeidenreichRafael SebastianLydia Dux-santoyJose M FerreroJose F. RodriguezJavier Saizsubject
Drugtherapy planningCardiac electrophysiologyHeart rhythm disordersComputer sciencemedia_common.quotation_subjectComputer Science (all)Cardiac electrophysiologyDofetilide3d modelmulti-scale modelingsimulationdrug cardio-toxicityTheoretical Computer ScienceTECNOLOGIA ELECTRONICAdrug modelingCardiac electrophysiology; drug cardio-toxicity; drug modeling; multi-scale modeling; simulation; therapy planning; Computer Science (all); Theoretical Computer SciencemedicineHeart beatAction potential durationNeurosciencemedicine.drugmedia_commondescription
[EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneity. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration. Pseudo-ECGs obtained for each heart beat correlated well with cellular results showing prolongation of QT segment. These techniques can be applied over the development of more complex drugs that affect multiple cellular currents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |