0000000000586344

AUTHOR

Jose F. Rodriguez

showing 2 related works from this author

Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study

2010

[EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneit…

Drugtherapy planningCardiac electrophysiologyHeart rhythm disordersComputer sciencemedia_common.quotation_subjectComputer Science (all)Cardiac electrophysiologyDofetilide3d modelmulti-scale modelingsimulationdrug cardio-toxicityTheoretical Computer ScienceTECNOLOGIA ELECTRONICAdrug modelingCardiac electrophysiology; drug cardio-toxicity; drug modeling; multi-scale modeling; simulation; therapy planning; Computer Science (all); Theoretical Computer SciencemedicineHeart beatAction potential durationNeurosciencemedicine.drugmedia_common
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An atlas- and data-driven approach to initializing reaction-diffusion systems in computer cardiac electrophysiology

2016

The cardiac electrophysiology (EP) problem is governed by a nonlinear anisotropic reaction-diffusion system with a very rapidly varying reaction term associated with the transmembrane cell current. The nonlinearity associated with the cell models requires a stabilization process before any simulation is performed. More importantly, when used in a 3-dimensional (3D) anatomy, it is not sufficient to perform this stabilization on the basis of isolated cells only, since the coupling of the different cells through the tissue greatly modulates the dynamics of the system. Therefore, stabilization of the system must be performed on the entire 3D model. This work develops a novel procedure for the i…

Work (thermodynamics)Basis (linear algebra)Computer scienceCardiac electrophysiologyApplied Mathematics0206 medical engineeringBiomedical EngineeringInitialization02 engineering and technology030204 cardiovascular system & hematology020601 biomedical engineeringData-drivenModeling and simulation03 medical and health sciencesNonlinear system0302 clinical medicineComputational Theory and MathematicsControl theoryModeling and SimulationReaction–diffusion systemMolecular BiologyAlgorithmSoftwareInternational Journal for Numerical Methods in Biomedical Engineering
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