Search results for "Dog"
showing 10 items of 1087 documents
Different conformations of nascent polypeptides during translocation across the ER membrane
2000
Abstract Background In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the ribosome. Results We have previously shown that the conformation of nascent polypeptide chains in transit through the ribosome-translocon complex can be probed by measuring the number of residues required to span the distance between the ribosomal P-site and the lumenally disposed active site of the oligosaccharyl transfer…
Multiple granular cell tumors with metachronous occurrence in tongue and vulva. Clinicopathological and immunohistochemical study
2014
Granular cell tumor (GCT) usually occurs as a single tumor, although sometimes multiple lesions can occur. In present report we analyze the clinicopathological and immunohistochemical features of a multiple GCT involving the tongue of a 14-year-old girl, with no other abnormalities, with a metachronous occurrence of a second GCT in vulva, after a period of 10 years. Both tumors revealed S-100, vimentin and CD57 positivity. In addition, over expression of calretinin was observed in tumor cells located in the vicinity of pseudoepitheliomatous hyperplasia (PEH) of the tongue. Tumor vasculature situated close to the PEH showed marked CD105 reactivity, data not described so far, suggesting an in…
Di cani e d'altro
2007
sonetti della poetessa Agathì Dimitruka tradotti in italiano da Maria Caracausi e volti metricamente da Paolo Scrima sonnets by the poet Agathì Dimitruka translated into Italian by Maria Caracausi and metric faces by Paolo Scrima
The Hamilton Depression Scale and Its Alternatives: A Comparison of Their Reliability and Validity
1990
The efficacy of medical treatments is evidenced by a demonstrated reduction in the severity of the disorder being treated relative to a control condition. At the beginning of the era of psychopharmacology, in the late 1950s, neither a well-defined concept nor a well-defined measurement of the severity of depression, schizophrenia, or anxiety disorders were available. Consequently, it was difficult to compare groups of treated patients on the basis of treatment-specific rates of recovery. Hamilton was one of the first to recognize this lack and to create methods for standardizing the measurement of the effects of drugs across both patients and treatments. His idea was that a standardized mea…
Spectral Density Estimate for Stable Processes Observed with an Additive Error
2018
International audience; In this paper, a symmetric alpha stable process where its spectral representation has an additive error is considered. The error is supposed to be constant. A periodogram as estimator of the spectral density and its rate of convergence are given. In order to give an asymptotically unbiased and consistent estimate of the spectral density, this periodogram is smoothed by an adapted spectral window. The rate of convergence is given.
Management of Listeria monocytogenes on Surfaces via Relative Air Humidity: Key Role of Cell Envelope
2021
International audience; Although relative air humidity (RH) strongly influences microbial survival, its use for fighting surface pathogens in the food industry has been inadequately considered. We asked whether RH control could destroy Listeria monocytogenes EGDe by envelope damage. The impact of dehydration in phosphate-buffered saline (PBS) at 75%, 68%, 43% and 11% RH on the bacterial envelope was investigated using flow cytometry and atomic force microscopy. Changes after rehydration in the protein secondary structure and peptidoglycan were investigated by infrared spectroscopy. Complementary cultivability measurements were performed by running dehydration–rehydration with combinations o…
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
AbstractPluripotency is maintained by both known and unknown transcriptional regulatory networks. In the present study, we have identified Zfp819, a KRAB-zinc finger protein, as a novel pluripotency-related factor and characterized its role in pluripotent stem cells. We show that Zfp819 is expressed highly in various types of pluripotent stem cells but not in their differentiated counterparts. We identified the presence of non-canonical nuclear localization signals in particular zinc finger motifs and identified them as responsible for the nuclear localization of Zfp819. Analysis of the Zfp819 promoter region revealed the presence of a transcriptionally active chromatin signature. Moreover,…
Proposal for a new diagnostic horizon for WRB Anthrosols
2009
Abstract To investigate man's role in the creation and evolution of soils in areas of large scale farming, and to investigate the main morpho-descriptive aspects of the related soils, a survey was carried out in south eastern Sicily, Italy, where, as common to other regions of the Mediterranean basin, there are wide areas with anthropogenic soils due to large scale farming activity. The complex genesis pattern of these anthropogenic soils, which shows a double sequence of man-made horizons, sideways oriented to the soil surface, does not allow their classification as Technosols, because their composition is not dominated or strongly influenced by artefacts or human-made materials as is the …
Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats
2007
As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in free cytosolic calcium ([Ca2+]i) in acutely dissociated small dorsal root ganglion neurons (diameter: ≤30 μm). Anandamide (10 μM) increased [Ca2+]iin 76% of the neurons. The EC50was 7.41 μM, the Hill slope was 2.15 ± 0.43 (mean ± SE). This increase was blocked by the competitive TRPV1-antagonist capsazepine (10 μM) and in Ca2+-free extracellular solution. Neither exclusion of voltage-gated sodium channels nor additional blockade of voltage-gate…
Single-particle properties of the Hubbard model in a novel three-pole approximation
2017
We study the 2D Hubbard model using the Composite Operator Method within a novel three-pole approximation. Motivated by the long-standing experimental puzzle of the single-particle properties of the underdoped cuprates, we include in the operatorial basis, together with the usual Hubbard operators, a field describing the electronic transitions dressed by the nearest-neighbor spin fluctuations, which play a crucial role in the unconventional behavior of the Fermi surface and of the electronic dispersion. Then, we adopt this approximation to study the single-particle properties in the strong coupling regime and find an unexpected behavior of the van Hove singularity that can be seen as a prec…