Search results for "Domu"
showing 10 items of 167 documents
A homolog of the putative tumor suppressor QM in the sponge Suberites domuncula: downregulation during the transition from immortal to mortal (apopto…
1999
Abstract The activation of components of the transcription factors such as AP-1 or c-jun is essential for a physiological response of metazoan cells during aging. The activity of such proto-oncoproteins is under enzymatic control. The function of c-jun is additionally modulated by the QM protein. Here, we studied the expression of the gene, encoding the QM-like protein in the sponge Suberites domuncula . These animals contain high levels of telomerase in their somatic cells. To understand the switch from telomerase-positive immortal cells to telomerase-negative mortal cells which undergo apoptosis, the expression of the QM-like gene was measured in this system. The cDNA, termed QMSD , encod…
Aborta aizlieguma sadursme ar cilvēktiesībām
2018
Aborts ir grūtniecības pārtraukšanas process. Par to tiek diskutēts mūsdienās, bet vēstures fakti norāda, ka kādreiz par to tika runāts saistībā ar reliģiju, sabiedrības morāles principiem vai ētiku, tad mūsdienās šī tēma ir aktuāla vairāk no tiesību aspekta. Darba tēma ir – Aborta aizlieguma sadursme ar cilvēktiesībām, šī tēma mūsdienās ir aktuāla, jo plaši tiek publicēti gadījumi, kad sieviete grūtniecības dēļ ir zaudējusi dzīvību, jo nav bijusi piekļuve grūtniecības pārtraukšanai. Kā arī vēl nesen 2016. gadā sievietes Polijā gāja piketēt par savu neapmierinātību, jo valdība vēlējas grozīt likumu, kur regulējums būtu drastiskāks. Statistikas dati norāda, ka sievietes ceļo uz citām Eiropas…
Metazoan Circadian Rhythm: Toward an Understanding of a Light-Based Zeitgeber in Sponges
2013
In all eukaryotes, the 24-h periodicity in the environment contributed to the evolution of the molecular circadian clock. We studied some elements of a postulated circadian clock circuit in the lowest metazoans, the siliceous sponges. First, we identified in the demosponge Suberites domuncula the enzyme luciferase that generates photons. Then (most likely), the photons generated by luciferase are transmitted via the biosilica glass skeleton of the sponges and are finally harvested by cryptochrome in the same individual; hence, cryptochrome is acting as a photosensor. This information-transduction system, generation of light (luciferase), photon transmission (through the siliceous spicules),…
Ethylene modulates gene expression in cells of the marine sponge Suberites domuncula and reduces the degree of apoptosis.
1999
Sponges (phylum Porifera) live in an aqueous milieu that contains dissolved organic carbon. This is degraded photochemically by ultraviolet radiation to alkenes, particularly to ethylene. This study demonstrates that sponge cells (here the demosponge Suberites domuncula has been used), which have assembled to primmorphs, react to 5 microM ethylene with a significant up-regulation of intracellular Ca(2+) concentration and with a reduction of starvation-induced apoptosis. In primmorphs from S. domuncula the expression of two genes is up-regulated after exposure to ethylene. The cDNA of the first gene (SDERR) isolated from S. domuncula encodes a potential ethylene-responsive protein, termed ER…
EVOLUTION OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
1999
Porifera (sponge) form the lowest metazoan phylum and share a common ancestor with other metazoan phyla. In the present study, it is reported that sponges possess molecules that are similar in structure to those molecules involved in the immune system in mammals. Experiments with the marine sponges Geodia cydonium and Suberites domuncula have been performed on tissue (auto- and allografting) as well as on a cellular level. The studies revealed that sponges are provided with elements of the mammalian innate immune system, such as molecules containing scavenger receptor cysteine-rich domains. Furthermore, macrophage-derived cytokine-like molecules have been identified that are up-regulated du…
TASSINARI / VETTA，信件工廠 / Tassinari/Vetta. The factory of letters
2009
的里雅斯特，一個以憂鬱的方式，將肘部靠在窗戶的門檻上，望著大海，是Tassinari / Vetta工作室的所在地，在那里工作完成了對項目的細緻投入的連貫循環，不斷研究和實驗，與短暫的趨勢相距甚遠，而是堅定地依賴於國家和國際，圖形和印刷傳統。然而在工作室裡，人們繼續偏愛那些已經影響到所有人的真正的痴迷，將其僅僅空間變成一個神話般的信件工廠，每個人都在設計中工作，到執行和設置那些將被選擇並用於各種任務的人。這些是首先構思，然後培養，教育和攜帶，直到它們成熟。這種方式可以幫助他們完成將思想轉化為清晰易讀的艱鉅任務，不僅可以作為聲音的正式表達，還可以作為充滿意義的小容器。 Trieste, the city which in a melancholy way, leaning his elbows upon the threshold of the window, looks at the sea, is the seat of the Tassinari/Vetta Studio, where the work completes a coherent cycle made of meticulous devotion to the project, of continuous research and experimentation, quite distant from the transitory trends, but rather firmly anchored to the national and international, graphic and typogra…
La cuisine d’une maison de maître du Haut-Empire à Grand (Vosges)
2013
During excavations conducted in 2011 in Grand (Vosges), a domus dating from the 2nd century and the first half of the 3rd was uncovered. Among the well-preserved vestiges a kitchen was identified with its cooking installations still in situ. These consisted of a hearth, a raised cooking platform and an oven. The kitchen was probably in use for both the residential and the servant’s quarters of the domus. The sediments linked to the use of the kitchen yielded numerous organic remains and pottery sherds dating from the 3rd century. These finds document, at least partially, the kitchenware in use, diet and waste management practices in use in this household. The kitchen stands out as a place t…
Okadaic Acid, an Apoptogenic Toxin for Symbiotic/Parasitic Annelids in the Demosponge Suberites domuncula
2006
ABSTRACT The role of okadaic acid (OA) in the defense system of the marine demosponge Suberites domuncula against symbiotic/parasitic annelids was examined. Bacteria within the mesohyl produced okadaic acid at concentrations between 32 ng/g and 58 ng/g of tissue (wet weight). By immunocytochemical methods and by use of antibodies against OA, we showed that the toxin was intracellularly stored in vesicles. Western blotting experiments demonstrated that OA also existed bound to a protein with a molecular weight of 35,000 which was tentatively identified as a galectin (by application of antigalectin antibodies). Annelids that are found in S. domuncula undergo apoptotic cell death. OA is one ca…
Bruton tyrosine kinase-like protein, BtkSD, is present in the marine sponge Suberites domuncula.
2003
Sponges, the simplest and most ancient phylum of Metazoa, encode in their genome complex and highly sophisticated proteins that evolved together with multicellularity and are found only in metazoan animals. We report here the finding of a Bruton tyrosine kinase (BTK)-like protein in the marine sponge Suberites domuncula (Demospongiae). The nucleotide sequence of one sponge cDNA predicts a 700-aa-long protein, which contains all of the characteristic domains for the Tec family of protein tyrosine kinases (PTKs). The highest homology (38% identity, 55% overall similarity) was found with human BTK and TEC PTKs. Sponge PTK was therefore named BtkSD. Human BTK is involved in the maturation of B …
Early evolution of metazoan serine/threonine and tyrosine kinases: identification of selected kinases in marine sponges.
1997
The phylum Porifera (sponges) was the first to diverge from the common ancestor of the Metazoa. In this study, six cDNAs coding for protein-serine/threonine kinases (PS/TKs) are presented; they have been isolated from libraries obtained from the demosponges Geodia cydonium and Suberites domuncula and from the calcareous sponge Sycon raphanus. Sequence alignments of the catalytic domains revealed that two major families of PS/TK, the "conventional" (Ca(2+)-dependent) protein kinase C (PKC), the cPKC subfamily, as well as the "novel" (Ca(2+)-independent) PKC (nPKC), form two separate clusters. In each cluster, the sequence from S. raphanus diverges first. To approach the question about the or…