Search results for "Don"
showing 10 items of 8430 documents
Epidemiology, clinical manifestations, risk-reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agen…
2014
Osteonecrosis of the jaws (ONJ) is an adverse side event of bisphosphonates and denosumab, antiresorptive agents that effectively reduce the incidence of skeletal-related events in patients with metastatic bone cancer and multiple myeloma. Available data suggest that 0–27.5% of individuals exposed to antiresorptive agents can develop ONJ. There is increasing evidence that avoidance of surgical trauma and infection to the jawbones can minimize the risk of ONJ, but there are still a significant number of individuals who develop ONJ in the absence of these risk factors. Bone necrosis is almost irreversible and there is no definitive cure for ONJ with the exclusion, in certain cases, of surgica…
Oral and dental health of Italian drug addicted in methadone treatment
2019
Objectives: Our group recorded the characteristic of oro-dental health among a group of drug addicts in recovery treatment with methadone, and it evaluated the changes related to the withdrawal therapy. Methodology: A sample of 50 drug addicts in treatment with methadone was included in this study. At the beginning of the withdrawal therapy, the authors recorded the parameters involved in the most common oral diseases. Moreover, it was evaluated how, during the rehabilitation protocol, the behavioral parameters and the xerostomia that influence the oral health changed. A medical history especially referring to drug addiction features was made. An intraoral objective exam was done for each p…
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofil…
2017
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1b. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from th…
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS
2018
Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.
Tumor odontogenico adenomatoide folicular: estudio inmunohistoquimico
2006
El tumor odontogénico adenomatoide (TOA) es una infrecuente lesión odontogénica benigna, que aparece en pacientes jóvenes, generalmente mujeres en la segunda década de la vida, a menudo como una lesión radiolúcida de aspecto quístico unilocular, en asociación a un diente, usualmente canino, no erupcionado. A pesar de haberse denominado también adenoameloblastoma o tumor ameloblástico adenomatoide, el TOA es una lesión benigna con una muy baja tendencia a la recidiva, mostrando una morfología muy peculiar (apariencia basaloide con estructuras glanduliformes, calcificaciones esferulares, presencia de material amiloide) que facilitan su reconocimiento histológico. Se presenta un análisis clíni…
Tumor odontogenico adenomatoide folicular: Estudio inmunohistoquimico
2006
El tumor odontogénico adenomatoide (TOA) es una infrecuente lesión odontogénica benigna, que aparece en pacientes jóvenes, generalmente mujeres en la segunda década de la vida, a menudo como una lesión radiolúcida de aspecto quístico unilocular, en asociación a un diente, usualmente canino, no erupcionado. A pesar de haberse denominado también adenoameloblastoma o tumor ameloblástico adenomatoide, el TOA es una lesión benigna con una muy baja tendencia a la recidiva, mostrando una morfología muy peculiar (apariencia basaloide con estructuras glanduliformes, calcificaciones esferulares, presencia de material amiloide) que facilitan su reconocimiento histológico. Se presenta un análisis clíni…
Informaation ja palvelun laatu tietojärjestelmän menestystekijöinä pienten ja keskisuurten asiantuntijaorganisaatioiden johdon raportoinnissa
2010
Yrityksissä käytetään paljon rahaa tietojärjestelmien hankintaan ja ylläpitoon. Tietojärjestelmien on tuotettava vastinetta niihin käytettyihin investointeihin. Tietojärjestelmien hyödyllisyyttä ja kannattavuutta voidaan tutkia menestystekijöiden avulla. Tietojärjestelmien menestystekijöitä ovat muun muassa informaation ja palvelun laatu, joihin tässä pro gradu-tutkielmassa keskityttiin. Jotta käyttäjä on tyytyväinen järjestelmään, järjestelmän on oltava laadukas niin teknisiltä ominaisuuksiltaan kuin informaation ja palvelun laadun osalta. Tässä tutkielmassa tutkittiin informaation ja palvelun laatua tietojärjestelmän menestystekijöinä pienten ja keskisuurten asiantuntijaorganisaatioiden j…
Quality of service and pricing in future multiple service class networks
2006
Ari Viinikainen tutki väitöskirjassaan tietoliikenneverkkojen resurssien jakoa hinnoittelun ja palvelun laadun avulla sekä kiinteissä että langattomissa tietoliikenneverkoissa. Aihe on ajankohtainen, sillä vaikka verkkojen tiedonsiirtokapasiteetti kasvaa, ei kaikille sovelluksille voida taata niiden vaatimaa tiedonsiirtopalvelun laatua. Esimerkiksi videoneuvottelujen laadun kannalta olennaisia ovat mahdollisimman pieni viive, vähäinen viiveen vaihtelu ja suuri tiedonsiirtokapasiteetti. Viinikainen esittelee työssään useita viiveen tai tiedonsiirtonopeuden takaavia algoritmeja, joilla reitittimiin saapuvaa dataa voidaan priorisoida. Algoritmien toiminta perustuu siirrettävän tiedon erilaisee…
Yhdyskuntajätevedenpuhdistamon rejektivesien erilliskäsittely : biologinen typenpoisto panostoimisessa reaktorissa ja ftalaattien käyttäytyminen pros…
2006
Gli oracoli di distruzione contro l’Egitto Ez 29–32 alla luce della retorica ebraica
2021
Commentators of the Book of Ezekiel achieved different results when it comes to the structures of the oracle. This was the context of the research undertaken. The aim was to develop the structures of the oracle according to the scientific method by Roland Meynet. The research was based on «analysis of the biblical text by the method of Hebrew rhetoric». As a result of the research, it was discovered that there are six (rather than seven) oracles. The first three oracles have parallel structures, the next three have parallel-concentric structures. It was also possible to discover numerical systems that either confirm the content of the text or introduce new information that is not written in…