Search results for "Donor"

showing 10 items of 436 documents

Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells

2019

[Background] Own mother’s milk (OMM) is the optimal nutrition for preterm infants. However, pasteurized donor human milk (DHM) is a valid alternative. We explored the differences of the transcriptome in exfoliated epithelial intestinal cells (EEIC) of preterm infants receiving full feed with OMM or DHM.

Male0301 basic medicineDonor milkGene Expressionintestinal cellsmedicine.disease_causeTranscriptome0302 clinical medicinemother’s milkGene expressionInfant Very Low Birth Weightoxidative stressgeneticsProspective StudiesIntestinal Mucosa2. Zero hungerPrincipal Component AnalysisNutrition and DieteticsCaseinsIntestinal cells3. Good healthdonor milkGestationFemalemedicine.symptomPrematuritylcsh:Nutrition. Foods and food supplyInfant PrematureGestational Agelcsh:TX341-641InflammationBiologyArticleAndrology03 medical and health sciences030225 pediatricsMother’s milkGeneticsmedicineHumansGeneInflammationMilk HumanprematurityInfant NewbornNADPH OxidasesEpithelial CellsNeutrophil cytosolic factor 1Low birth weight030104 developmental biologyMilk BanksOxidative stressinflammationCyclooxygenase 1LactalbuminTranscriptomeOxidative stressFood ScienceNutrients
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The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Do…

2015

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes …

MaleAnálisis de supervivenciatrasplante de células madre hematopoyéticasmedicine.medical_treatmenthumanos:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings]Graft vs Host Diseaselcsh:MedicinePolimorfismo genético:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Hematopoietic stem cell transplantationStem cellsRegiones promotoras genéticas:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Trasplante homólogoIL-2 receptorLymphocytesMasculinoPromoter Regions Geneticlcsh:Sciencemediana edadancianoMultidisciplinaryAdultoFemenino:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [Medical Subject Headings]Hematopoietic Stem Cell TransplantationFOXP3Forkhead Transcription Factorsadultoanálisis de supervivenciaMiddle AgedTissue DonorsHumanosestudios de asociación genéticaadulto jovenmedicine.anatomical_structuresurgical procedures operativeCèl·lules T:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Transcription Factors::Winged-Helix Transcription Factors::Forkhead Transcription Factors [Medical Subject Headings]Female:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]Factores de transcripción en cabeza de tenedorCèl·lules mareTrasplante de células madre hematopoyéticasResearch ArticleAdult:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]GenotypeGraft-vs-Leukemia EffectRegulatory T cellAncianoT cells:Check Tags::Male [Medical Subject Headings]Graft vs Leukemia Effectfactores de transcripción en cabeza de tenedorHuman leukocyte antigenBiologyEnfermedad injerto contra huéspedLimfòcitsYoung AdultDonantes de tejidos:Named Groups::Persons::Tissue Donors [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineHumansTransplantation Homologous:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Genetic Association StudiesAgedMediana edadTransplantationPolymorphism GeneticEstudios de asociación genéticaEfecto injerto contra leucemialcsh:Rdonantes de tejidostrasplante:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]medicine.diseaseSurvival Analysis:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Transplantation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]efecto injerto contra leucemiaGraft-versus-host disease:Check Tags::Female [Medical Subject Headings]Immunology:Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Graft vs Host Reaction::Graft vs Tumor Effect::Graft vs Leukemia Effect [Medical Subject Headings]enfermedad injerto contra huésped:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Regulatory Elements Transcriptional::Promoter Regions Genetic [Medical Subject Headings]lcsh:QgenotipoGenotipoPLoS ONE
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Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study

2001

Abstract The involvement of nitric oxide (NO) in cerebral blood flow (CBF) stimulation by acetazolamide was studied in anaesthetised, mechanically ventilated Wistar rats. CBF was monitored by laser Doppler scanning. Acetazolamide induced a long-lasting significant rCBF-increase. Application of N G -Nitro- l -arginine (L-NNA), an inhibitor of all NO synthetases (NOS), prevented CBF stimulation by acetazolamide. Continuous infusion of the exogenous NO donor SIN-1 (3-morpholinosydnonimine) suppressed L-NNA induced increases of mean arterial blood pressure without effect on rCBF in comparison to baseline. Additional acetazolamide injection then again caused a significant increase of rCBF in spi…

MaleArginineVasodilator AgentsHemodynamicsBlood PressureStimulationPharmacologyNitric OxideNitroarginineNitric oxidechemistry.chemical_compoundLaser-Doppler FlowmetrymedicineAnimalsNitric Oxide DonorsRats WistarCarbonic Anhydrase InhibitorsCerebral CortexChemistryGeneral NeuroscienceLaser Doppler velocimetryRatsAcetazolamidemedicine.anatomical_structurenervous systemCerebral blood flowCerebral cortexCerebrovascular CirculationMolsidomineAnesthesiaNitric Oxide SynthaseAcetazolamidecirculatory and respiratory physiologymedicine.drugNeuroscience Letters
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Becoming and being a biobank donor: The role of relationships and ethics

2020

Relational aspects, such as involvement of donor’s relatives or friends in the decision-making on participation in a research biobank, providing relatives’ health data to researchers, or sharing research findings with relatives should be considered when reflecting on ethical aspects of research biobanks. The aim of this paper is to explore what the role of donor’s relatives and friends is in the process of becoming and being a biobank donor and which ethical issues arise in this context. We performed qualitative analysis of 40 qualitative semi-structured interviews with biobank donors and researchers. The results show that relatedness to relatives or other types of close relationships playe…

MaleBiomedical ResearchEmotionsFace (sociological concept)Social SciencesFriendsResearch EthicsCognitionSociologyInformed consentMedicine and Health SciencesPsychologyHuman FamiliesResearch Integritymedia_commonBiological Specimen Banks0303 health sciencesMultidisciplinary030305 genetics & heredityQRPublic relationsResearch AssessmentMiddle AgedBiobankResearch PersonnelTissue DonorsGeneral Data Protection RegulationMedicineFemalePsychologyResearch ArticleMedical EthicsAdultScience PolicyScienceDecision MakingClinical Decision-MakingContext (language use)Research and Analysis Methods03 medical and health sciencesGeneticsmedia_common.cataloged_instanceHumansFamilyEuropean union030304 developmental biologyNutritionAgedResearch ethicsMotivationbusiness.industryCognitive PsychologyBiology and Life SciencesLatviaDietCognitive SciencebusinessMedical HumanitiesMedical ethicsNeurosciencePLoS ONE
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Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase

1991

Rat liver dihydrodiol dehydrogenase (DDH, E.C. 1.3.1.20) has recently been shown to oxidize the highly carcinogenic benz[a]anthracene-3,4- dihydrodiol in an NADP(+)-dependent reaction to its corresponding catechol. The present study is a systematic investigation of the substrate specificity of the purified enzyme towards synthetic trans-dihydrodiol metabolites of phenanthrene, benz[a]anthracene, chrysene, dibenz[a, h]anthracene and benzo[a]pyrene. DDH exhibited a remarkable regiospecificity of enzymatic catalysis with regard to the site of the dihydrodiol moiety of the parent hydrocarbon. M-region- and, with lower efficiency, bay-region dihydrodiols were found to be good substrates of the e…

MaleChryseneOxidoreductases Acting on CH-CH Group DonorsAnthraceneStereochemistryMetaboliteGeneral MedicinePhenanthreneToxicologyCatalysisDihydroxydihydrobenzopyrenesRatsSubstrate SpecificityEnzyme catalysisAlcohol OxidoreductasesKineticschemistry.chemical_compoundLiverchemistryBenzo(a)pyrenepolycyclic compoundsAnimalsPyreneOxidoreductasesCarcinogenChemico-Biological Interactions
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Serologic and molecular characterization of weak D type 29

2017

MaleDNA ComplementaryTunisiaImmunologyBlood Donors030204 cardiovascular system & hematologyBiologyPolymorphism Single NucleotideWhite PeopleArticleSerology03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePhylogeneticsGermanyHumansImmunology and AllergyAlleleAllelesPhylogenyGeneticsRh-Hr Blood-Group SystemExonsHematologyBlood Grouping and CrossmatchingHaplotypeschemistryChromosomes Human Pair 1FemaleDNA030215 immunologyTransfusion
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Enzyme polymorphisms and haemoglobin variants in Greeks

1975

Several enzyme polymorphisms and hemoglobin variants were typed in a sample of n = 219 non-related Greek blood-donors. The following gene frequencies were observed: pa = 0.201, pb = 0.701, pc = 0.098;PGDA = 0.985, PGDc = 0.015; AK1 = 0.942, AK2 = 0.058; HbA = 0.988, HbS = 0.012. No polymorphic variation was seen in LDH, s-MDH, PHI, or SOD. The population genetical aspects of these results are discussed.

MaleHemoglobins AbnormalAcid PhosphatasePopulationBlood DonorsBiologyHaemoglobin variantsGene FrequencyMalate DehydrogenaseGeneticsHumansMetabolic diseaseeducationGeneAllele frequencyAllelesGenetics (clinical)Geneticschemistry.chemical_classificationeducation.field_of_studyPolymorphism GeneticGreeceL-Lactate DehydrogenaseSuperoxide DismutasePhosphogluconate DehydrogenasePhosphotransferasesGlucose-6-Phosphate IsomeraseGenetic VariationHemoglobin variantsMolecular biologyAK2IsoenzymesPhenotypeEnzymechemistryFemaleHuman Genetics
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Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.

2009

The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a p…

MaleIndazolesMolsidomineParkinson's disease (PD)Substantia nigraPharmacologyNitric OxideNeuroprotectionSettore BIO/09 - FisiologiaGeneral Biochemistry Genetics and Molecular BiologyNitric oxideRats Sprague-Dawleychemistry.chemical_compoundNeurochemicalHistory and Philosophy of ScienceDopaminemedicineAnimalsNitric Oxide DonorsOxidopaminenitric oxide (NO)corpus striatumGeneral Neurosciencesubstantia nigra pars compacta (SNc)Dopaminergic6-hydroxydopamine (6-OHDA)Parkinson DiseaseRatsSubstantia NigrachemistryMolsidomineNeuroscienceOxidopaminemedicine.drug
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Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects(NTD).

1999

A number of studies have demonstrated that the common polymorphism 677CT in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR) leads to a thermolabile variant with decreased enzyme activity and to mildly elevated plasma homocysteine. 677TT homozygosity was shown to be more frequent in NTD probands compared with controls in some studies. Recently, another polymorphism, 1298AC, in the MTHFR gene was described and combined heterozygosity 677CT/1298AC was suggested to be an additional risk factor for NTD. The present study examines the genotype and haplotype distribution of the two polymorphisms in the German population and evaluates the impact on NTD individuals and their rela…

MaleLinkage disequilibriumGenotypePopulationLinkage DisequilibriumFetusGene FrequencyGermanyHumansNeural Tube DefectseducationAllele frequencyGenetics (clinical)AllelesMethylenetetrahydrofolate Reductase (NADPH2)Genetic associationGeneticsFamily Healtheducation.field_of_studyOxidoreductases Acting on CH-NH Group DonorsPolymorphism GeneticbiologyHaplotypeTransmission disequilibrium testDNAGenotype frequencyPedigreeHaplotypesMethylenetetrahydrofolate reductaseCase-Control StudiesPopulation SurveillanceMutationbiology.proteinFemaleAmerican journal of medical genetics
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Irregularity of the posterior corneal surface after curved interface femtosecond laser-assisted versus microkeratome-assisted descemet stripping auto…

2013

During donor tissue preparation for Descemet stripping automated endothelial keratoplasty (DSAEK), either microkeratome or femtosecond laser can be used for intrastromal cutting. We compared morphological and functional outcomes after DSAEK using both cutting techniques.In this retrospective study, 22 uneventful DSAEK surgeries were reviewed. Eight donor corneas were prepared for DSAEK using the VisuMax femtosecond laser (Carl Zeiss Meditec AG, Jena, Germany). Fourteen corneas were processed using an Amadeus II microkeratome (Ziemer Ophthalmic Systems AG, Port, Switzerland). The postoperative best spectacle-corrected visual acuity was measured. Furthermore, corneal optical coherence tomogra…

MaleMaterials sciencegenetic structuresDonor tissueVisual AcuityCell Countlaw.inventionOpticsOrgan Culture TechniqueslawMicrokeratomeHumansCorneal surfaceAgedRetrospective StudiesAged 80 and overbusiness.industryEndothelium CornealFuchs' Endothelial DystrophyCorneal TopographyMiddle AgedDescemet stripping automated endothelial keratoplastyLaser assistedLasereye diseasesTissue DonorsOphthalmologyFemtosecondFemalesense organsLaser TherapybusinessDescemet Stripping Endothelial KeratoplastyTomography Optical CoherenceBiomedical engineeringCornea
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