Search results for "Dons"

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

2020

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…

Biomechanics and functional morphology of a climbing monocot.

2015

Climbing monocots can develop into large bodied plants despite being confined by primary growth. In our study on Flagellaria indica we measured surprisingly high stem biomechanical properties (in bending and torsion) and we show that the lack of secondary growth is overcome by a combination of tissue maturation processes and attachment mode. This leads to higher densities of mechanically relevant tissues in the periphery of the stem and to the transition from self-supporting to climbing growth. The development of specialised attachment structures has probably underpinned the evolution of numerous other large bodied climbing monocot taxa.

Bilateral ruptures of the extensor mechanism of the knee: A systematic review

2017

Abstract Introduction We conduct a systematic and qualitative review of the current literature to evaluate studies that described bilateral ruptures of the extensor mechanism of the knee. Methods A comprehensive literature search was performed to evaluate all studies included in the literature until September 2016. Results Fourteen studies with a total of 44 patients met the inclusion criteria. There were 14 patients with CRF (61%), 6 patients were affected by diabetes mellitus (14%) while other 6 patients were obese patients (14%). Conclusion CRF represents the most frequent comorbidity in patients with bilateral quadriceps/patellar tendon ruptures.

Jaunu alkilaizvietotu 4-fenil-2-pirolidonu sintēze un ķīmisko īpašību izpēte

2016

Jaunu alkilaizvietotu 4-fenil-2-pirolidonu sintēze un ķīmisko īpašību izpēte. Baškevičs V., darba vadītāji: Dr.chem. Maksims Vorona, asoc. prof. Anda Prikšāne. Bakalaura darbs. 32 lappuses, 18 attēli, 18 literatūras avoti. Latviešu valodā. Izstrādātas jaunas 5-alkilaizvietoto 4-fenil-2-pirolidonus iegūšanas metodes, izmantojot malonātu vai 2-fluormalonāta esteru Mihaela pievienošanu -alkil--nitrostirolam, kā arī nitroalkānu pievienošanu kanēļskābes metilesterim. Iegūtie starpprodukti tika hidrogenēti paaugstinātā spiedienā Reneja niķeļa katalizatora klātbūtnē, veidojot 5-alkil-4-fenil-3-karboksi-2-pirolidonu un 5-metil-4-fenil-3-fluoro-3-karboksi-2-pirolidona esterus, vai 5-alkil-4-fenil-…

Yield measurements at IGISOL with a digital data acquisition system

2017

A new digital data acquisition system has been installed at the IGISOL facility at the department of Physics in University of Jyväskylä in November, 2016. The technical details of the hardware and software of this new system are presented in this thesis. Nutaq VHS-ADC digital data acquisition system includes an analogue to digital converter (ADC) crate board, an offset unit box, an acquisition host PC, and a storage drive. This system consists of 8 channels, has the capability of 105 MSPS with 14-bit ADCs on 6U cPCI (PXI compatible). Radioactive sources, beta-gamma matrix, gamma-gamma matrix, beta-delayed gamma, and gamma-delayed gamma spectra of radioactive isotopes produced at IGISOL were…

Rise of the tendon research.

2016

Mantenimiento de la lactancia materna exclusiva a los 3 meses posparto: experiencia en un departamento de salud de la Comunidad Valenciana

2019

Resumen: Objetivos: Determinar la prevalencia de la lactancia materna exclusiva (LME) a los 3 meses posparto, y conocer las causas que contribuyen al abandono precoz. Diseño: Estudio observacional y restrospectivo. Emplazamiento: Departamento de Salud de la Ribera, Valencia, España. Participantes: Niños nacidos entre diciembre de 2012 y enero de 2017. Mediciones principales: prevalencia de lactancia materna al alta y de LME a los 3 meses. Motivos de abandono de LME. Determinación de Chi-cuadrado entre variables categóricas. Metodología: Las mujeres fueron entrevistadas en el posparto y a los 3 meses posparto, teniendo en cuenta las variables asociadas al inicio de la lactancia y su continua…

The value of MRI in the evaluation of the ACL deficient knee and in the post-operative evaluation after ACL reconstruction

1993

To evaluate the usefulness of magnetic resonance imaging (MRI) in the exploration of the anterior cruciate ligament (ACL) deficient-knee, a total of twenty-five patients with chronic instability of the knee joint and who underwent both MRI and arthroscopy were studied prospectively. Twenty-three of these patients underwent an intra-articular reconstruction of the ACL with bone-patellar tendon-bone autografts. For the ACL lesions MRI had a sensitivity of 95.8%, a specificity of 100% and a diagnostic accuracy of 97.7%. Associated bowing of the PCL was seen in 20 cases of the study group. For the associated meniscal lesions MRI had a sensitivity of 77.7%, a specificity of 94.7% and a diagnosti…

Age-specific neuromuscular interaction during elderly habitual running

2015

Aim It has been reported that advancing age causes tendons to become more compliant and fascicles length shorter. This could then lead to enhancement of movement efficiency provided that the elderly adults can activate their muscles in the same way as the younger adults (YOUNG) during dynamic movements. This study was designed to examine the age-specific behaviour of the medial gastrocnemius (MG) fascicles and tendinous tissues together with lower-leg muscle activities when the well-trained elderly runners ran on the treadmill at preferred speeds. Methods The well-trained 11 elderly subjects (ELD) who have running experiences and 11 YOUNG were recruited as subjects. While ELD were running o…

Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath.

2001

The expression of cysteine proteinases cathepsins B and K and of the endogenous inhibitor of cysteine proteinases, cystatin C, was investigated in tissue specimens of patients with giant cell tumor of tendon sheath (GCTTS). Expression of both enzymes was examined by immunohistochemistry in tissue specimens of 14 patients with GCTTS. Applying double-labeling techniques, the coexpression of cathepsin B and its major endogenous inhibitor cystatin C was additionally studied. Cells expressing the respective proteins were further characterized with the macrophage markers HAM56 and anti-CD68 (clone PG-M1). Cathepsin B could be detected in numerous HAM56-positive mononuclear cells (MC), but only in…