Search results for "Dop"
showing 10 items of 4870 documents
Coupling hydrodynamics and radiation calculations for star-jet interactions in active galactic nuclei
2016
Context. Stars and their winds can contribute to the non-thermal emission in extragalactic jets. Because of the complexity of jet-star interactions, the properties of the resulting emission are closely linked to those of the emitting flows. Aims. We simulate the interaction between a stellar wind and a relativistic extragalactic jet and use the hydrodynamic results to compute the non-thermal emission under different conditions. Methods. We performed relativistic axisymmetric hydrodynamical simulations of a relativistic jet interacting with a supersonic, non-relativistic stellar wind. We computed the corresponding streamlines out of the simulation results and calculated the injection, evolut…
Acogimiento familiar: estudio de las interacciones ante las visitas familiares
1999
La ley orgánica 1/96 sobre Protección Jurídica del niño, establece una medida de protección denominada acogimiento familiar preadoptivo, en aquellos supuestos en donde se valora como irreversible el retorno a la familia de origen del niño, y en donde se dispone de una familia alternativa para la integración social de los niños. La regulación del régimen de visitas compete, en primer lugar, a la administración responsable de la protección a la infancia y, en segundo lugar, a la Fiscalía de Menores, quien a través del Juzgado de Familia podrá regular judicialmente el régimen de visitas. El desarrollo de estas visitas y su plasmación en actos concretos está mediatizado por la complejidad de la…
An adoption model for mobile banking in Ghana
2009
The impact of social and cultural factors on the adoption of technology still requires much research. To investigate it more fully, we examine the reasons for the adoption and non-adoption of mobile banking in Ghana. Through a survey of 271 people in Ghana, it has been found that social and cultural factors in the form of perceived credibility, facilitating conditions, perceived elitisation and demographic factors do play a significant role in adoption decisions. It has been found that elitisation of technology and services can be a positive influence for adopters whilst being a negative influence for non-adopters. In addition, perceived credibility and facilitating conditions also influenc…
The specificity of the functioning of orphan children in the context of prenatal life
2019
Prenatal life is the time of the physical, mental and social development of a human being. It is a kind of “base” that supports all further post-natal development. Increasingly, attention is being drawn to the fact that the success of the adoption depends on providing the new guardians with accurate information about the child’s past and his family, the impact of his previous experience on the current functioning, and their predicted long-term effects. Although it is not correct to say that adopted children are different compared to other children, those who meet them in their work and people who are orphans themselves say they are different. Adopted children come from two worlds and during…
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
2009
AbstractTo study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)–targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell–specific restoration of a functional Rag1 transcription unit. Follicular and marginal zone B cells populated the spleen when Rag1 expression was permitted. Notably, the peritoneal cavity was dominated by bona fide B-1a cells, as judged by surface markers and functional properties. These BM-derived B-1a cells exhibited a polyclonal VDJ repertoire with substantial N nucleotide insertions. Nevertheless, physiologic frequencies of phosphatidylcholine-specific B cells were detected. Import…
Controversies on the role of Th17 in cancer: a TGF-β-dependent immunosuppressive activity?
2012
The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known, their roles in cancer remain ambiguous. Despite adoptive transfer studies indicating that mouse Th17 cells support anticancer immunity, the Th17 cells that naturally infiltrate experimental tumors appear to have a tumor-promoting effect. These contradictory properties can be related to the high degree of plasticity inherent in Th17 cells and their capacity to differentiate into tumoricidal Th1-like cells. Mouse Th17 cells induced by transfo…
Gene Therapy With a High-Affinity Single-Chain p53-Specific TCR Mediates Potent Anti-Tumor Response Without Inducing Gvhd In Vivo
2013
Abstract The adoptive transfer of tumor-reactive cells is a promising approach in the treatment of human malignancies, but the challenge of isolating T cells with high-avidity for tumor antigens in each patient has limited its widespread application. Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53(264-272) tumor-associated antigen and developed approaches to generate high-affinity CD8-independent TCR. However, a safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the g…
Endogenous CD83 Expression in CD4+ Conventional T Cells Controls Inflammatory Immune Responses
2020
Abstract The glycoprotein CD83 is known to be expressed by different immune cells including activated CD4+Foxp3+ regulatory T cells (Tregs) and CD4+Foxp3− conventional T cells. However, the physiological function of endogenous CD83 in CD4+ T cell subsets is still unclear. In this study, we have generated a new CD83flox mouse line on BALB/c background, allowing for specific ablation of CD83 in T cells upon breeding with CD4-cre mice. Tregs from CD83flox/flox/CD4-cretg/wt mice had similar suppressive activity as Tregs from CD83flox/flox/CD4-crewt/wt wild-type littermates, suggesting that endogenous CD83 expression is dispensable for the inhibitory capacity of Tregs. However, CD83-deficient CD…
Functional Analyses of Human T Cell Extravasation in a Humanized NOD/SCID/IL2Rγcnull Transplantation Model.
2009
Abstract Abstract 2448 Poster Board II-425 Donor lymphocyte graft engineering to avoid graft-versus-host (GVH) reactivity while improving graft-versus-leukemia (GVL) immunity remains of central interest in allogeneic hematopoietic stem cell transplantation (HSCT). However, appropriate models to evaluate experimental concepts of donor lymphocyte allograft engineering in vivo are missing. We, therefore, established a human-murine chimeric transplantation model using immunodeficient NOD/SCID/IL2Rγcnull (NSG) mice to evaluate GVH reactivity of human T cell grafts in vivo. Moreover, since mechanisms of immune functions resembling human GVH immunity have not yet been addressed in detail in these …
Induction of the anti-ergotypic response.
1993
The injection of syngeneic activated T cells into rodents can induce a T cell response against activation markers of the T cells, ergotopes. The responding anti-ergotypic T cells have been shown to suppress experimental autoimmune encephalomyelitis (EAE). This paper reports the characteristics of the anti-ergotypic response. It was found that irradiated activated T cells were as good as untreated living activated T cells in inducing anti-ergotypic cells in vivo. Glutardialdehyde-fixed (0.3%) cells were poor stimulators in vivo and non-stimulatory in vitro. Dilution of glutardialdehyde to 0.003% before fixation preserved the stimulatory capacity in vitro. Fixation or irradiation of T cells a…