Search results for "Dorsolateral"

showing 10 items of 62 documents

Anodal transcranial direct current stimulation of the right dorsolateral prefrontal cortex enhances memory-guided responses in a visuospatial working…

2014

Several studies have shown that transcranial direct current stimulation (tDCS) is able to enhance performances on verbal and visual working memory (WM) tasks. Available evidence points to the right dorsolateral prefrontal cortex (DLPFC) as a critical area in visual WM, but to date direct comparisons of the effects obtained by stimulating the left versus the right DLPFC in the same subject are lacking. Our aim was to determine whether tDCS over the right DLPFC can differently affect performance as compared with left DLPFC stimulation. Ten healthy subjects performed a memory-guided visuospatial task in three conditions: baseline, during anodal stimulation applied over the right and during ano…

AdultMaleWorking memoryPrefrontal CortexArticlesTranscranial Direct Current Stimulationbehavioral disciplines and activitiesFunctional LateralityYoung AdultMemory Short-Termnervous systemVisual PerceptionHumansFemaleDorsolateral prefrontal cortexpsychological phenomena and processesSpatial Memory
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Parieto-frontal interactions in visual-object and visual-spatial working memory: Evidence from transcranial magnetic stimulation

2001

This study aimed to investigate whether transcranial magnetic stimulation (TMS) can induce selective working memory (WM) deficits of visual-object versus visual-spatial information in normal humans. Thirty-five healthy subjects performed two computerized visual n-back tasks, in which they were required to memorize spatial locations or abstract patterns. In a first series of experiments, unilateral or bilateral TMS was delivered on posterior parietal and middle temporal regions of both hemispheres after various delays during the WM task. Bilateral temporal TMS increased reaction times (RTs) in the visual-object, whereas bilateral parietal TMS selectively increased RTs in the visual-spatial W…

AdultMalegenetic structuresCognitive Neurosciencemedicine.medical_treatmentStimulus (physiology)behavioral disciplines and activitiesSpatial memoryNOCellular and Molecular NeuroscienceMemoryParietal LobemedicineHumansPrefrontal cortexAdult; Electric Stimulation; Female; Frontal Lobe; Humans; Male; Memory; Parietal Lobe; Photic Stimulation; Psychomotor Performance; Scalp; Space Perception; Transcranial Magnetic StimulationScalpSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaWorking memorymusculoskeletal neural and ocular physiologyTranscranial Magnetic StimulationElectric StimulationFrontal LobeDorsolateral prefrontal cortexTranscranial magnetic stimulationmedicine.anatomical_structurenervous systemSuperior frontal gyrusFrontal lobeSpace PerceptionFemaleSettore MED/26 - NeurologiaScalp; Humans; Electric Stimulation; Parietal Lobe; Frontal Lobe; Memory; Photic Stimulation; Adult; Space Perception; Psychomotor Performance; Transcranial Magnetic Stimulation; Female; MalePsychologyNeurosciencepsychological phenomena and processesPhotic StimulationPsychomotor PerformanceHuman
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Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression

2011

Background: Mood disorders are associated with the highest increase of attempted and completed suicide. Suicidality in major depressive disorder and in schizophrenia has been associated with reduced gray matter volumes in orbitofrontal cortex. Lithium reduces the suicide risk of patients with bipolar disorder (BD) to the same levels of the general population, and can increase GM volumes. We studied the effect of a positive history of attempted suicide and ongoing lithium treatment on regional GM volumes of patients affected by bipolar depression. Methods: With a correlational design, we studied 57 currently depressed inpatients with bipolar disorder: 19 with and 38 without a positive histor…

AdultMalemedicine.medical_specialtyBipolar DisorderDecision MakingPopulationPrefrontal CortexSuicide Attempted03 medical and health sciences0302 clinical medicinemedicineHumansBipolar disorderPsychiatryPrefrontal cortexeducationCerebral CortexTemporal cortexDepressive DisorderDepressive Disorder Majoreducation.field_of_studyDepressionMood DisordersOrgan SizeMiddle Agedmedicine.disease030227 psychiatry3. Good healthDorsolateral prefrontal cortexSuicidePsychiatry and Mental healthClinical Psychologymedicine.anatomical_structureMood disordersCase-Control StudiesLithium CompoundsMajor depressive disorderFemaleOrbitofrontal cortexPsychologyGoals030217 neurology & neurosurgeryClinical psychology
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Repetitive TMS over the left dorsolateral prefrontal cortex modulates the error positivity: An ERP study

2019

Abstract Error processing is a critical step towards an efficient adaptation of our behavior to achieve a goal. Little research has been devoted to investigate the contribution of the dorsolateral prefrontal cortex (DLPFC) in supporting error processing. In this study, the causal relationship of the DLPFC in error commission was examined by means of a repetitive transcranial magnetic stimulation protocol (rTMS). Specifically, the effects of an inhibitory protocol were assessed by examining the electroencephalographic signal recorded during the execution of a Go/No-Go task. To this aim, a group of 15 healthy young participants performed a three-session study. At each session, either the righ…

AdultMalemedicine.medical_specialtyError awareness Post-error slowing (PES) Transcranial magnetic stimulation (TMS) Error positivity (Pe) Error-related negativity (ERN) Dorsolateral prefrontal cortex (DLPFC)Post-error slowing (PES)Cognitive Neurosciencemedicine.medical_treatmentPrefrontal CortexExperimental and Cognitive PsychologyStimulationAudiologyInhibitory postsynaptic potentialbehavioral disciplines and activities050105 experimental psychologyFunctional LateralityTask (project management)03 medical and health sciencesBehavioral NeuroscienceYoung Adult0302 clinical medicineTranscranial magnetic stimulation (TMS)mental disordersmedicineError positivity (Pe)Humans0501 psychology and cognitive sciencesEvoked PotentialsLeft dorsolateral prefrontal cortexError processingDorsolateral prefrontal cortex (DLPFC)05 social sciencesError awareneBrainNegativity effectElectroencephalographyAwarenessTranscranial Magnetic StimulationTranscranial magnetic stimulationDorsolateral prefrontal cortexInhibition Psychologicalmedicine.anatomical_structurenervous systemStroop TestFemaleError-related negativity (ERN)Psychologypsychological phenomena and processes030217 neurology & neurosurgery
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Interest of targeting either cortical area Brodmann 9 or 46 in rTMS treatment for depression: a preliminary randomized study.

2013

Abstract Objective To assess the interest of specifically targeting Brodmann Areas (BA) 9 or 46 for rTMS treatment of depression. Methods Patients with Treatment-Resistant Depression were randomly assigned to two treatment groups to receive either rTMS on BA 9 or on BA 46. Each patient underwent 10 sessions of 1Hz-rTMS for 2weeks. The Hamilton and Montgomery–Asberg Depression Rating Scales (HDRS, MADRS) were used under blind conditions to assess the therapeutic response (50% improvement). A Wilcoxon signed-rank test was used to compare the depression rating scales scores obtained before and after the 10 rTMS sessions for each of the two groups. The therapeutic results in the two groups were…

AdultMalemedicine.medical_specialtyWilcoxon signed-rank testAudiologybehavioral disciplines and activitieslaw.inventionDepressive Disorder Treatment-ResistantRandomized controlled trialRating scalelawPhysiology (medical)medicineHumansPsychiatryDepression (differential diagnoses)AgedCerebral CortexBrain MappingMiddle AgedTranscranial Magnetic StimulationSensory SystemsDorsolateral prefrontal cortexmedicine.anatomical_structureNeurologyFemaleNeurology (clinical)PsychologyClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Modulating memory performance in healthy subjects with Trancranial Direct Current Stimulation over the right dorsolateral prefrontal cortex

2015

Objective: The role of the Dorsolateral Prefrontal Cortex (DLPFC) in recognition memory has been well documented in lesion, neuroimaging and repetitive Transcranial Magnetic Stimulation (rTMS) studies. The aim of the present study was to investigate the effects of transcranial Direct Current Stimulation (tDCS) over the left and the right DLPFC during the delay interval of a non-verbal recognition memory task. Method: 36 right-handed young healthy subjects participated in the study. The experimental task was an Italian version of Recognition Memory Test for unknown faces. Study included two experiments: in a first experiment, each subject underwent one session of sham tDCS and one session of…

AdultMalemedicine.medical_specialtymedicine.medical_treatmentPrefrontal Cortexlcsh:MedicineAudiologybehavioral disciplines and activitiesnon-verbal recognition memoryYoung AdultNeuroimagingMemorydorsolateral prefrontal cortex.Reaction TimemedicineHumanstranscranial direct current stimulation; non-verbal recognition memory; dorsolateral prefrontal cortex.Prefrontal cortexlcsh:ScienceRecognition memoryMultidisciplinaryTranscranial direct-current stimulationSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaLong-term memorybusiness.industrylcsh:RHealthy subjectsRecognition PsychologyTranscranial magnetic stimulationDorsolateral prefrontal cortexmedicine.anatomical_structureFemalelcsh:Qtranscranial direct current stimulationbusinesspsychological phenomena and processesResearch Article
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Prefrontal and temporo-parietal involvement in taking others' perspective: TMS evidence.

2008

INTRODUCTION: Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). Behavioural and functional neuroimaging evidence suggests that prefrontal and temporo-parietal cortices are involved in these abilities. The present study was aimed at investigating the role of the dorsolateral prefrontal cortex and temporo-parietal junction in ToM by using a repetitive transcranial magnetic stimulation (rTMS) paradigm. MATERIAL AND METHODS: Eleven healthy subjects participated in the study. The experimental ToM procedure was constituted by false belief and faux-pas written stories. Subjects were evaluated in baseline condition (Sham) and after 1Hz …

AdultMalemedicine.medical_treatmentCulturePrefrontal CortexNeurosciences. Biological psychiatry. NeuropsychiatryTHEORY OF MINDbehavioral disciplines and activitiesFunctional neuroimagingTheory of mindParietal Lobemental disordersmedicineReaction TimeSocial Perception; Culture; Humans; Temporal Lobe; Adult; Prefrontal Cortex; Transcranial Magnetic Stimulation; Parietal Lobe; Male; Female; Reaction TimeHumansBRAINPrefrontal cortexSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaParietal lobeCognitionGeneral MedicineTranscranial Magnetic StimulationTemporal LobeTranscranial magnetic stimulationDorsolateral prefrontal cortexNeuropsychology and Physiological Psychologymedicine.anatomical_structureNeurologyMentalizationnervous systemSocial PerceptionmentalizingSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyNeurosciencepsychological phenomena and processesRC321-571Cognitive psychologyResearch Article
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Recognition memory and prefrontal cortex: Dissociating recollection and familiarity processes using rTMS

2008

Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recog…

AdultMalemedicine.medical_treatmentNeurosciences. Biological psychiatry. NeuropsychiatryContext (language use)Recognition (Psychology)behavioral disciplines and activitiesPrefrontal cortexNORecognition memoryJudgmentRecollectionEncoding (memory)mental disordersmedicineHumansJudgment; Memory; Recognition (Psychology); Humans; Adult; Mental Recall; Prefrontal Cortex; Transcranial Magnetic Stimulation; Male; FemalePrefrontal cortexTMS; MEMORYLeft dorsolateral prefrontal cortexRecognition memoryRecallSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMEMORYHealthy subjectsRecognition PsychologyGeneral MedicineFamiliarityTranscranial Magnetic StimulationTranscranial magnetic stimulationNeuropsychology and Physiological Psychologynervous systemNeurologyTMSMental RecallFemaleSettore MED/26 - NeurologiaNeurology (clinical)Psychologypsychological phenomena and processesFamiliarity; Prefrontal cortex; Recognition memory; Recollection;Research ArticleRC321-571Cognitive psychology
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Neural correlates of antinociception in borderline personality disorder.

2006

Context A characteristic feature of borderline personality disorder (BPD) is self-injurious behavior in conjunction with stress-induced reduction of pain perception. Reduced pain sensitivity has been experimentally confirmed in patients with BPD, but the neural correlates of antinociceptive mechanisms in BPD are unknown. We predicted that heat stimuli in patients with BPD would activate brain areas concerned with cognitive and emotional evaluation of pain. Objective To assess the psychophysical properties and neural correlates of altered pain processing in patients with BPD. Design Case-control study. Setting A university hospital. Participants Twelve women with BPD and self-injurious behav…

AdultPain Thresholdmedicine.medical_specialtyHot TemperatureDifferential ThresholdPainPrefrontal CortexAudiologybehavioral disciplines and activitiesAmygdalaGyrus CingulimethodsArts and Humanities (miscellaneous)bloodBorderline Personality DisorderPhysical StimulationAdult Amygdala; physiopathology Borderline Personality Disorder; diagnosis/physiopathology/psychology Brain Mapping Brain; physiopathology Case-Control Studies Differential Threshold; physiology Female Gyrus Cinguli; physiopathology Hot Temperature; diagnostic use Humans Magnetic Resonance Imaging Oxygen; blood Pain Measurement; methods Pain Threshold; physiology Pain; diagnosis/physiopathology/psychology Physical Stimulation Prefrontal Cortex; physiopathology Self-Injurious Behavior; diagnosis/physiopathology Thermosensing; physiologymental disordersThreshold of painmedicineHumansThermosensingPrefrontal cortexPsychiatryBorderline personality disorderPain MeasurementBrain MappingBlood-oxygen-level dependentmedicine.diagnostic_testBrainmedicine.diseaseAmygdalaMagnetic Resonance Imagingdiagnosis/physiopathologyFunctional imagingDorsolateral prefrontal cortexOxygenPsychiatry and Mental healthmedicine.anatomical_structureCase-Control StudiesphysiologyFemalediagnosis/physiopathology/psychologyphysiopathologydiagnostic useFunctional magnetic resonance imagingPsychologySelf-Injurious BehaviorArchives of general psychiatry
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Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients.

2012

Alterations in the structure and physiology of the prefrontal cortex (PFC) have been found in different psychiatric disorders and some of them involve inhibitory networks, especially in schizophrenia and major depression. Changes in the structure of these networks may be mediated by the polysialylated neural cell adhesion molecule (PSA-NCAM), a molecule related to neuronal structural plasticity, expressed in the PFC exclusively by interneurons. Different studies have found that PSA-NCAM expression in the hippocampus and the amygdala is altered in schizophrenia, major depression and animal models of these disorders, in parallel to changes in the expression of molecules related to inhibitory …

Adultmedicine.medical_specialtyBipolar DisorderSynaptophysinHippocampusPrefrontal CortexNeural Cell Adhesion Molecule L1NeurotransmissionHippocampusmedicineNeuropilHumansPsychiatryPrefrontal cortexAgedDepressive Disorder MajorNeuronal PlasticitybiologyGlutamate DecarboxylaseGeneral NeuroscienceMental DisordersNeural InhibitionMiddle AgedAmygdalaDorsolateral prefrontal cortexmedicine.anatomical_structurenervous systemSynaptic plasticitySynapsesVesicular Glutamate Transport Protein 1Synaptophysinbiology.proteinSchizophreniaSialic AcidsNeural cell adhesion moleculePsychologyNeuroscienceNeuroscience letters
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