Search results for "Dying"

showing 10 items of 33 documents

Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich ataxia

2016

Frataxin (FXN) deficiency causes Friedreich's ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous structures. A dying-back mechanism has been proposed to explain the peripheral neuropathy and neuropathology. In addition, affected individuals have non-neuronal symptoms such as diabetes mellitus or glucose intolerance. To go further in the understanding of the pathogenic mechanisms of neuropathy and diabetes associated with the disease, we have investigated the humanized mouse YG8R model of FRDA. By bio…

0301 basic medicineNervous systemAgingPathologylcsh:MedicineMedicine (miscellaneous)Mice0302 clinical medicineImmunology and Microbiology (miscellaneous)Ganglia SpinalInsulin-Secreting CellsInsulin SecretionInsulinMuscle spindleDorsal root gangliaCellular SenescenceDiabetisbiologyMusclesDiabetesAnatomyMitochondria3. Good healthmedicine.anatomical_structureSistema nerviós simpàticDying-back neuropathyPeripheral nervous systemCell senescencemedicine.symptomOxidation-Reductionlcsh:RB1-214Research ArticleSenescencemedicine.medical_specialtyAtaxiaNeuroscience (miscellaneous)Friedreich’s ataxiaNeuropathologyGeneral Biochemistry Genetics and Molecular BiologyPàncreesMalalties del sistema nerviós03 medical and health sciencesPeripheral Nervous Systemlcsh:PathologymedicineAnimalsHumansPancreasIslet of Langerhanslcsh:R302Friedreich's ataxiaNervous system Diseasesmedicine.diseaseAxonsMice Inbred C57BLDisease Models Animal030104 developmental biologyPeripheral neuropathyFriedreich AtaxiaSympathetic nervous systemMutationHumanized mouseFrataxinbiology.proteinEnergy Metabolism030217 neurology & neurosurgeryDisease Models & Mechanisms
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Pre-service Primary Teachers' Scientific Knowledge and Attitudes towards Science Learning and Their Influence on the Understanding of the Nature of S…

2016

The present study focused on the knowledge about the nature of science and the question of the extent to which this knowledge could be explained by employing scientific knowledge, as well as attitudes towards science learning. We obtained data from 171 Spanish pre-service primary school teachers on their knowledge about: a) science concepts, b) science process skills, c) the nature of science (that was split into science construction and validation and the role and function of scientific models), and d) their attitudes towards science learning. Quantitative and qualitative analyses provided interesting results: a) there were significant correlations between any pair of scores of conceptual …

ComputingMilieux_COMPUTERSANDEDUCATIONobilježja praktične znanosti; budući nastavnici; pogledi na znanost; proučavanje znanosti; razumijevanje znanostifeatures of working science; prospective elementary teachers; science views; studying science; understanding of scienceCroatian Journal of Education : Hrvatski časopis za odgoj i obrazovanje
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Knowledge about Palliative Care and Attitudes toward Care of the Dying among Primary Care Nurses in Spain

2023

Objective: To analyze the knowledge in palliative care and the attitudes toward caring for the dying of nurses who carry out their professional activity in primary care in Spain. Design: A cross-sectional descriptive observational study was carried out among Spanish primary care centers. Participants: A total of 244 nurses who had completed their primary care work and agreed to participate in this study were included. Main measurements: The level of knowledge in palliative care was analyzed using the PCQN-SV scale, and attitudes toward care of the dying were measured with the FATCOD-S scale, both of which are instruments that are validated in Spain. Results: Regarding the level of knowledge…

Health Information ManagementAtenció primàriapalliative care; knowledge; primary care; nursing; care of the dyingLeadership and ManagementInfermeriaHealth PolicyHealth Informatics
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Assessing quality of care for the dying from the bereaved relatives' perspective: Using pre-testing survey methods across seven countries to develop …

2019

Background: The provision of care for dying cancer patients varies on a global basis. In order to improve care, we need to be able to evaluate the current level of care. One method of assessment is to use the views from the bereaved relatives. Aim: The aim of this study is to translate and pre-test the ‘Care Of the Dying Evaluation’ (CODETM) questionnaire across seven participating countries prior to conducting an evaluation of current quality of care. Design: The three stages were as follows: (1) translation of CODE in keeping with standardised international principles; (2) pre-testing using patient and public involvement and cognitive interviews with bereaved relatives; and (3) utilising …

MaleQuality Assurance Health Careproxycognitive interviewingProxy (climate)Survey methodology0302 clinical medicineGermanySurveys and QuestionnairesOutcome Assessment Health CareTerminal careMedicineNorwayPalliative CarePre testingOutcome measuresGeneral MedicineMiddle Aged3. Good healthPeer reviewquality of healthcareCaregiverssurvey and questionnaire030220 oncology & carcinogenesisFemalequality of care for the dying0305 other medical scienceBrazilAdultmedicine.medical_specialtyArgentina03 medical and health sciences030502 gerontologyHumansTerminally IllFamilyQuality of careCognitive interviewAgedbusiness.industryOriginal ArticlesUnited KingdomCross-Sectional StudiesAnesthesiology and Pain MedicineFamily medicineUruguayPolandLevel of carebusinessBereavement
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Controlled sedation for refractory symptoms in dying patients.

2008

Terminally ill cancer patients near the end of life may experience intolerable suffering refractory to palliative treatment. Although sedation is considered to be an effective treatment when aggressive efforts fail to provide relief in terminally ill patients, it remains controversial. The aim of this study was to assess the need and effectiveness of sedation in dying patients with intractable symptoms, and the thoughts of relatives regarding sedation. A prospective cohort study was performed on a consecutive sample of dying patients admitted to an acute pain relief and palliative care unit within a cancer center. Indications for sedation, opioid and midazolam doses, level of delirium and s…

Malerefractory symptomPalliative carePalliative treatmentSedationPainRefractoryNeoplasmscontrolled sedationmedicineHumansProspective cohort studyGeneral NursingPain MeasurementTerminal Caredying patientsbusiness.industryPalliative CareMiddle AgedAnalgesics OpioidAnesthesiology and Pain MedicineTreatment OutcomeOpioidAnesthesiaMidazolamDeliriumFemaleNeurology (clinical)medicine.symptombusinessmedicine.drug
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Teacher trainees' experiences of the components of ICT competencies and key factors in ICT competence development in work-based vocational teacher tr…

2022

International journal for research in vocational education and training 9 (2022) 2, S. 146-166

MedienkompetenzLehrerausbildungBerufsschuleeducational technologyDigitale MedienPupil EvaluationBerufs- und WirtschaftspädagogikMedia competence370 Erziehung Schul- und Bildungswesendigitalizationammatilliset opettajat20100Questionnaire surveyinformation technologytyössäoppiminenComputingMilieux_COMPUTERSANDEDUCATIONFragebogenerhebungBildung und ErziehungFinlandWork-Based Learningteaching staffWork-Based Learning; Teacher ICT Competencies; Vocational Education and Training VETUtilization of mediavocational educationInformations- und KommunikationstechnologieLehre und Studium Professionalisierung und Ethik Organisationen und Verbände der ErziehungswissenschaftVocational Training Adult EducationLehrpersonalcommunication technologyStudent teachersneue TechnologieBerufsbildungTeacher ICT Competenciesnew technologyLernumgebungEducational Environment370 EducationLehramtsstudentKompetenzInhaltsanalyseDigitalisierungLeistungsbeurteilungTeacher educationInteractionErziehung Schul- und Bildungswesentieto- ja viestintätekniikkaVocational school for apprenticescompetenceMedia skillsEducationBildungswesen quartärer Bereich BerufsbildungAchievement testddc:370Qualitative researchErwachsenenbildung / WeiterbildungMediennutzungVocational Education and TrainingKommunikationstechnologieddc:330LehrerbildungTraining Teaching and Studying Professional Organizations of Education and PedagogicsComputerunterstütztes VerfahrenUtilisation of mediaInformationstechnologieInteraktionTeacher TrainingLearning environmentQualitative ForschungTechnological Changeberufliche Weiterbildungammatillinen opettajankoulutusFinnlandadvanced vocational educationTeacher trainingAchievement measurementammatillinen kehitysBildungstechnologiekompetenssiVET10600Content analysis
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Fenotipo celular de las neuronas sensitivas afectadas en la ataxia de Friedreich

2016

Tesis Doctoral, 223 páginas, 64 figuras, 13 tablas.

Neurona sensitiva ganglio dorsalfallo mitocondrialfrataxinaataxia de Friedreichneurona sensitiva ganglio dorsalFallo mitocondrialReceptores acoplados a proteínas Greceptores acoplados a proteínas GDishomeostasis del calcioFrataxinaNeurodegeneración dying backneurodegeneración dying back240000dishomeostasis del calcioAtaxia de FriedreichModelo murino YG8Rmodelo murino YG8R320000
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The importance of horizontal-fit of university student jobs for future job quality

2019

Purpose The purpose of this paper is to gain a better understanding of the antecedents of the quality of graduates’ jobs when they enter the job market after university graduation. Design/methodology/approach Survey data collected from 173 Spanish bachelor and master’s degree university graduates at two time points (two months before and six months after graduation, approximately) were analyzed by means of path analysis. Findings A moderated mediation model was tested, where the relationship between the horizontal fit (HF) between the university degree subject and the student’s job and the quality of the graduate’s job after graduation is mediated by self-perceived employability and modera…

Organizational Behavior and Human Resource ManagementJob qualitymedia_common.quotation_subjectEmployabilityBachelorJob marketModerated mediation0502 economics and businessComputingMilieux_COMPUTERSANDEDUCATIONQuality (business)Time devoted to a student jobmedia_commonMedical educationHorizontal fit while studying (fit between university degree subject and student job)Self-perceived employabilityComputingMilieux_THECOMPUTINGPROFESSION05 social sciences050301 educationWork experienceJob qualityPsychology0503 educationInstitute for Management Research050203 business & managementSocial Sciences (miscellaneous)GraduationCareer Development International
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Les pratiques pédagogiques des enseignants universitaires :

2012

In France, some studies (Boyer & Coridian, 2002; Clanet, 2001) have highlighted the heterogeneity of teaching practices at the university, especially in the first year, but don't analyze accurately the effects of this variety on the students. However, these practices are not without consequences for them (Bireaud 1990; Bellat Duru, 1995; Galinon Menelec, 1996). So it is to this reflection that is dedicated the research presented in this article. Firstly will be presented studies in France and abroad about the description of practices. The second part will focus on the effects induced by them on students. Finally, we will present an innovative viewpoint of research, on the relationship betwe…

Pédagogie universitaire[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/Educationfreshman year[ SHS.EDU ] Humanities and Social Sciences/Educationteaching practices in universityPratique pédagogiqueways of studyingEnseignement supérieurUniversitémotivationHétérogénéitéEfficacité pédagogiqueMéthode d'apprentissageFranceheterogeneity and efficiency practicesSupérieur premier cycle
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Le poche luci e le molte ombre dei disegni di legge italiani in tema di morte medicalmente assistita

2022

The research analyzes the recent Italian draft laws on Medical Assistance in dying, their strengths and several shortcomings, comparing them with other European laws on this subject. The Italian draft laws are not fully hinged on the exercise of self-de- termination of the suffering person but remain bound to the reference to a condition of proximity to death or the presence of life-sustaining treatments, which in fact cause unjustified inequities in access to a health service aimed at protecting the dignity of the person. Furthermore, the articulation of the procedures for requesting and assessing suitability outlined in the Italian bills does not allow to fully protect the person in a con…

Settore MED/02 - Storia Della MedicinaHuman dignityItalyEuthanasiaTherapeutic self-determinationMedical assistance in dyingAssisted suicide
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