Search results for "Dynamic"
showing 10 items of 12329 documents
The changes of lipid metabolism in advanced renal cell carcinoma patients treated with everolimus: a new pharmacodynamic marker?
2015
Background: Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved for the treatment of metastatic renal cell carcinoma (mRCC). We aimed to assess the association between the baseline values and treatmentrelated modifications of total serum cholesterol (C), triglycerides (T), body mass index (BMI), fasting blood glucose level (FBG) and blood pressure (BP) levels and the outcome of patients treated with everolimus for mRCC. Methods: 177 patients were included in this retrospective analysis. Time to progression (TTP), clinical benefit (CB) and overall survival (OS) were evaluated. Results: Basal BMI was significantly higher in patients who experienced a CB (p=0,0145). C, T an…
A Multiple Local Models Approach to Accuracy Improvement in Continuous Glucose Monitoring
2011
Continuous glucose monitoring (CGM) devices estimate plasma glucose (PG) from measurements in compartments alternative to blood. The accuracy of currently available CGM is yet unsatisfactory and may depend on the implemented calibration algorithms, which do not compensate adequately for the differences of glucose dynamics between the compartments. Here we propose and validate an innovative calibration algorithm for the improvement of CGM performance.CGM data from GlucoDay(®) (A. Menarini, Florence, Italy) and paired reference PG have been obtained from eight subjects without diabetes during eu-, hypo-, and hyperglycemic hyperinsulinemic clamps. A calibration algorithm based on a dynamic glo…
Enhancement of immunohistochemical staining
1982
The present paper describes two simple procedures which enhance immunohistochemical staining. One is to cover the sections with a plastic film to keep the serum uniformly distributed and minimize its evaporation. Secondly, rocking of the slides has been introduced, causing the serum to flow back and forth under the plastic film. Using this system, it has been possible to test for the effect of mixing on an immunohistochemical reaction (the demonstration of calcitonin in thyroid C cells). It has been found that mixing definitely enhances the reaction during the first 8 h. No effect of serum volume was observed.
Mortality of ruptured abdominal aortic aneurysm with selective use of endovascular repair
2009
The aim of this review was to examine the results over a seven-year period of treatment for ruptured abdominal aortic aneurysm (RAAA). From 2002 on, our tertiary referral centre offered both open and endovascular (EVAR) treatment modalities for RAAA. All patients with a proven RAAA who were admitted into our hospital were included. Primary outcome measure was surgical mortality. In total 261 patients were admitted with suspicion of acute AAA. Of these, 175 (67%) had a RAAA, confirmed by computed tomography-scanning or at laparotomy. One hundred and fifty-nine patients (90.9%) were treated, 114 by open repair and 45 by EVAR. Overall mortality of patients treated was 25.2%, with an open repai…
Iterative momentum relaxation for fast lattice-boltzmann simulations
1999
Lattice-Boltzmann simulations are often used for studying steady-state hydrodynamics. In these simulations, however, the complete time evolution starting from some initial condition is redundantly computed due to the transient nature of the scheme. In this article we present a refinement of body-force driven lattice-Boltzmann simulations that may reduce the simulation time significantly. This new technique is based on an iterative adjustment of the local body-force and is validated on a realistic test case, namely fluid flow in a static mixer reactor.
Modelling and Simulation of Gas–liquid Hydrodynamics in a Rectangular Air-lift Reactor
2013
Abstract Computational Fluid Dynamics is a quite well established tool for carrying out realistic simulations of process apparatuses. However, as a difference from single phase systems, for multiphase systems the development of CFD models is still in progress. Among the two-phase systems, gas–liquid systems are characterised by an additional complexity level, related to the fact that bubble sizes are not known in advance, being rather the result of formation and breakage-coalescence dynamics and therefore of complex phenomena related to flow dynamics and interfacial effects. In the present work, Euler–Euler Reynolds-averaged flow simulations of an air-lift reactor are reported. All bubbles …
Physically-Based Approach to the Mechanics of Strong Non-Local Linear Elasticity Theory
2009
In this paper the physically-based approach to non-local elasticity theory is introduced. It is formulated by reverting the continuum to an ensemble of interacting volume elements. Interactions between adjacent elements are classical contact forces while long-range interactions between non-adjacent elements are modelled as distance-decaying central body forces. The latter are proportional to the relative displacements rather than to the strain field as in the Eringen model and subsequent developments. At the limit the displacement field is found to be governed by an integro-differential equation, solved by a simple discretization procedure suggested by the underlying mechanical model itself…
Casimir-Polder force density between an atom and a conducting wall
2007
In this paper we calculate the Casimir-Polder force density (force per unit area acting on the elements of the surface) on a metallic plate placed in front of a neutral atom. To obtain the force density we use the quantum operator associated to the electromagnetic stress tensor. We explicitly show that the integral of this force density over the plate reproduces the total force acting on the plate. This result shows that, although the force is obtained as a sum of surface element-atom contributions, the stress-tensor method includes also nonadditive components of Casimir-Polder forces in the evaluation of the force acting on a macroscopic object.
The Complex System Theory for the Analysis of Inter-Firm Networks: A Literature Overview and Theoretic Framework
2011
In this paper we discuss the body of knowledge known as complex system theory and its relevance to the analysis of inter-firm networks. We start by addressing the development of systems thinking. Through a literature overview, we point out the main elements for the development of systemic thought from its beginning, through its application in business sciences, to the birth of Complex Systems Theory (CST). With these initial annotations we provide an introduction to the concepts of the complex systems theory. We will underscore those aspects of CST that can be useful to analyze inter-firm networks, in order to highlight the evolutionary dynamics of the networks and to clarify the logical li…
A Non-Reductionist Physiologism: Nietzsche on Body, Mind and Consciousness
2013
This paper addresses the following questions from the point of view of Nietzsche’s philosophy: What is the mind, and which kind of relationship does it hold to the body? Accordingly, the aim of this paper is to show that Nietzsche’s philosophy suggested a view of the mind that allows to outline an alternative stance to both mentalism and physicalism, as well as to both dualism and reductionism. It is argued that Nietzsche’s rehabilitation of the body as the specific seat of the mind in opposition to the Cartesian supremacy of the Ego still is of a great interest for contemporary philosophy, since it is not equivalent either to a reversed form of Cartesian dualism or to a physicalist reducti…