Search results for "E-F"
showing 10 items of 836 documents
Regional Susceptibility in VCD Spectra to Dynamic Molecular Motions
2018
Experimental and theoretical studies of the vibrational circular dichroism (VCD) spectrum of 3-methyl-1-(methyldiphenlsilyl)-1-phenylbutan-1-ol, whose absolute configuration is key to elucidating the Brook rearrangement of tertiary benzylic α-hydroxylsilanes, are presented. It is found that the entire OH-bending region in this spectrum—a region that provides important marker bands—cannot be reproduced at all by standard theoretical approaches even though other regions are well described. Using a novel approach to disentangle contributions to the rotational strength of these bands, internal coordinates are identified that critically influence the appearance of this part of the spectrum. We s…
Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis
2012
Bacterial pathogens modulate host cell apoptosis to establish a successful infection. Pore-forming toxins (PFTs) secreted by pathogenic bacteria are major virulence factors and have been shown to induce various forms of cell death in infected cells. Here we demonstrate that the highly conserved caspase-2 is required for PFT-mediated apoptosis. Despite being the second mammalian caspase to be identified, the role of caspase-2 during apoptosis remains enigmatic. We show that caspase-2 functions as an initiator caspase during Staphylococcus aureus alpha-toxin- and Aeromonas aerolysin-mediated apoptosis in epithelial cells. Downregulation of caspase-2 leads to a strong inhibition of PFT-mediate…
Towards efficient inductive synthesis of expressions from input/output examples
1993
Our goal through several years has been the development of efficient search algorithm for inductive inference of expressions using only input/output examples. The idea is to avoid exhaustive search by means of taking full advantage of semantic equality of many considered expressions. This might be the way that people avoid too big search when finding proof strategies for theorems, etc. As a formal model for the development of the method we use arithmetic expressions over the domain of natural numbers. A new approach for using weights associated with the functional symbols for restricting search space is considered. This allows adding constraints like the frequency of particular symbols in t…
Le temps des unes et le temps des autres
2004
Dans une journée tout le monde dispose de vingt-quatre heures. De quelle manière le temps est-il compté, quantifié et analysé selon les institutions ? Les résultats de ces diverses enquêtes soulignent la persistance des inégalités dans la gestion des emplois du temps.
Phosphogenesis in the Bonarelli Level from northwestern Sicily, Italy: petrographic evidence of microbial mediation and related REE behaviour
2010
Phosphogenesis at the base of the Bonarelli Level from the Calabianca stratigraphic section (northwestern Sicily) was investigated using X-ray diffraction, scanning electron microscopy, X-ray fluorescence, and stable-isotope mass spectrometry. The anoxic event onset is marked by high P(2)O(5tot) concentrations related to the presence of authigenic carbonate-fluorapatite. This mineral is poorly crystallized and occurs in three different forms: (i) fish debris locally showing evidence of re-crystallization, (ii) phosphatically cemented layers, and (iii) dense aggregates of microcrystals. Petrographic features are indicative of a microbial genesis for the carbonate-fluorapatite. Conversely, th…
Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O.
2006
Following the observation that cells are able to recover from membrane lesions incurred by Staphylococcus aureus alpha-toxin and streptolysin O (SLO), we investigated the role of p38 in this process. p38 phosphorylation occurred in response to attack by both toxins, commencing within minutes after toxin treatment and waning after several hours. While SLO reportedly activates p38 via ASK1 and ROS, we show that this pathway does not play a major role for p38 induction in alpha-toxin-treated cells. Strikingly divergent effects of p38 blockade were noted depending on the toxin employed. In the case of alpha-toxin, inhibition of p38 within the time frame of its activation led to disruption of th…
Kilohertz and Low-Frequency Electrical Stimulation With the Same Pulse Duration Have Similar Efficiency for Inducing Isometric Knee Extension Torque …
2017
International audience; Objective To test the hypotheses that, as compared with pulsed current with the same pulse duration, kilohertz frequency alternating current would not differ in terms of evoked-torque production and perceived discomfort, and as a result, it would show the same current efficiency.Design A repeated-measures design with 4 stimuli presented in random order was used to test 25 women: (1) 500-microsecond pulse duration, (2) 250-microsecond pulse duration, (3) 500-microsecond pulse duration and low carrier frequency (1 kHz), (4) 250-microsecond pulse duration and high carrier frequency (4 kHz). Isometric peak torque of quadriceps muscle was measured using an isokinetic dyna…
Mannheimer Innovationspanel (MIP), Scientific-Use-Files der Jahre 1993-2016
2018
Das ZEW erhebt seit 1993 jährlich Daten zum Innovationsverhalten der deutschen Wirtschaft. Die Innovationserhebung deckt die Bereiche Bergbau, verarbeitendes Gewerbe, Energie, Baugewerbe, unternehmensnahe Dienstleistungen und distributive Dienstleistungen ab. Sie ist für Deutschland repräsentativ und ermöglicht Hochrechnung für die deutsche Wirtschaft insgesamt sowie für einzelne Branchengruppen. Es wird im Auftrag des BMBF und in Kooperation mit infas und dem Fraunhofer-ISI durchgeführt. Das MIP ist gleichzeitig der deutsche Beitrag zu den Community Innovation Surveys (CIS) der Europäischen Kommission. Die jährliche Innovationserhebung ist als Panelbefragung konzipiert. Dabei werden jedes …
Mannheimer Innovationspanel (MIP), Scientific-Use-Files der Jahre 1993-2014
2018
Das ZEW erhebt seit 1993 jährlich Daten zum Innovationsverhalten der deutschen Wirtschaft. Die Innovationserhebung deckt die Bereiche Bergbau, verarbeitendes Gewerbe, Energie, Baugewerbe, unternehmensnahe Dienstleistungen und distributive Dienstleistungen ab. Sie ist für Deutschland repräsentativ und ermöglicht Hochrechnung für die deutsche Wirtschaft insgesamt sowie für einzelne Branchengruppen. Es wird im Auftrag des BMBF und in Kooperation mit infas und dem Fraunhofer-ISI durchgeführt. Das MIP ist gleichzeitig der deutsche Beitrag zu den Community Innovation Surveys (CIS) der Europäischen Kommission. Die jährliche Innovationserhebung ist als Panelbefragung konzipiert. Dabei werden jedes …
Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from th…
2016
[Background] To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS).