Search results for "E-F"
showing 10 items of 836 documents
NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.
2019
Abstract Background Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to the target through the E1-E2-E3 enzymatic cascade, can be translated as a part of the protein they ought to regulate. As integral UbLs coexist with the rest of the protein, their structural properties can differ from canonical ubiquitin, depending on the protein context and how they interact with it. In this work, we investigate T.th-ubl5, a UbL present in a polyubiquitin locus of Tetrahymena thermophila, which is integral to an ADP-ribosyl transferase protein. Only one other co-occurrence of these two domains within the same protein has been reported. Methods NMR, multiple sequence al…
An Open-Label Phase II Study Evaluating the Safety and Efficacy of Ramucirumab Combined With mFOLFOX-6 as First-Line Therapy for Metastatic Colorecta…
2014
Abstract Author Summary Background. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2) are believed to mediate angiogenesis in colorectal cancer (CRC). Ramucirumab (RAM; IMC-1121B) is a human IgG1 monoclonal antibody that inhibits VEGF ligand binding to VEGFR-2, inhibiting VEGFR-2 activation and signaling. Methods. Patients with metastatic CRC, Eastern Cooperative Oncology Group performance status 0–1, and adequate organ function who had not received chemotherapy for metastatic disease received RAM and the modified FOLFOX-6 regimen every 2 weeks. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety. The sample size wa…
Compilation iconographique et légitimation de l'ordre dominicain : les fresques de Tomaso da Modena à San Nicolò de Trévise (1352)
1992
Russo Daniel. Compilation iconographique et légitimation de l'ordre dominicain: les fresques de Tomaso da Modena à San Niccolo de Trevise (1352). In: Revue de l'Art, 1992, n°97. pp. 76-84.
Investigation on a MMACHC mutant from cblC disease: The c.394C>T variant
2022
The cblC disease is an inborn disorder of the vitamin B12 (cobalamin, Cbl) metabolism characterized by methylmalonic aciduria and homocystinuria. The clinical consequences of this disease are devastating and, even when early treated with current therapies, the affected children manifest symptoms involving vision, growth, and learning. The illness is caused by mutations in the gene codifying for MMACHC, a 282aa protein that transports and transforms the different Cbl forms. Here we present data on the structural properties of the truncated protein p.R132X resulting from the c.394C > T mutation that, along with c.271dupA and c.331C > T, is among the most common mutations in cblC. Althou…
Calibration of a knock prediction model for the combustion of a gasoline-natural gas mixture
2009
Gaseous fuels, such as Liquefied Petroleum Gas (LPG) and Natural Gas (NG), thank to their good mixing capabilities, allow complete and cleaner combustion than normal gasoline, resulting in lower pollutant emissions and particulate matter. Moreover natural gas, which is mainly constituted by methane, whose molecule has the highest hydrogen/carbon ratio, leads also to lower ozone depleting emissions. The authors in a previous work (1) experienced the simultaneous combustion of gasoline and natural gas in a bi-fuel S.I. engine, exploiting so the high knock resistance of methane to run the engine with an ‘overall stoichiometric’ mixture (thus lowering fuel consumption and emissions) and better …
A thermodynamically consistent cohesive-frictional interface model for mixed mode delamination
2016
Abstract A new interface constitutive model based on damage mechanics and frictional plasticity is presented. The model is thermodynamically consistent, it is able to accurately reproduce arbitrary mixed mode debonding conditions and it is proved that the separation work is always bounded between the fracture energy in mode I and the fracture energy in mode II. Analytical results are given for proportional loading paths and for two non-proportional loading paths, confirming the correct behavior of the model for complex loading histories. Numerical and analytical solutions are compared for three classical delamination tests and frictional effects on 4ENF are also considered.
Early stages of beta2-microglobulin aggregation and the inhibiting action of alphaB-crystallin
2008
The interest of nucleation of protein crystals and aggregates (including oligomerization) spans from basic physics theory all the way to biophysics, nanophysics, clinical sciences, biotechnologies, food technologies and polymer-solvent interactions. Understanding nucleation within a theoretical framework capable of providing quantitative predictions and control of nucleation rates, or even the very occurrence of crystallization, is a long-sought goal of remarkable relevance to each of the above fields. A large amount of work has been aimed at such goal, but success has been so far rather limited. Work at our laboratory has more recently highlighted a direct link between nucleation rates and…
Model Free Control for muscular force by Functional Electrical Stimulation using pulse width modulation
2016
International audience; Functional Electrical Stimulation (FES) is a useful technique for restoring functions for patients with neurological disorders. Muscle activities can be artificially driven through delivery of electrical pulses to skeletal muscles. Typically, muscles are activated by using constant stimulation train with a fixed parameters (amplitude, frequency and pulse width). In addition, the FES systems do not adapt the parameters stimulation to obtain a desired force response during the rehabilitation session. The purpose of this study is to investigate a real-time FES system for adapting automatically the stimulation parameters (stimulation pulse width) to track a desired force…
Nouvelles données sur la localité type et la morphométrie dentaire du campagnol de Gerbe Microtus pyrenaicus gerbei (Gerbe, 1879) (Cricetidae, Rodent…
2015
New data on type locality and dental morphometry of the Gerbe’s vole Microtus pyrenaicus gerbei (Gerbe, 1879) (Cricetidae, Rodentia). The synthesis of the historical research done on Arthur de L’Isle du Dréneuf’s life, the discoverer of the Gerbe’s vole Microtus pyrenaicus gerbei (Gerbe, 1879), and the circumstances connected with this discovery, allow to say that its type locality is the municipality of La Haie-Fouassière (Loire-Atlantique, France). The analysis of teeth found in pellets of barn owl from Pornic (Loire-Atlantique, France) has confirmed the odontometrical differentiation previously observed in M. pyrenaicus gerbei.
Antoine Traisnel, Capture: American Pursuits and the Making of a New Animal Condition
2021
You can’t judge a book by its cover. Or so they say. But the cover of Antoine Traisnel’s Capture: American Pursuits and the Making of a New Animal Condition is striking and, one is tempted to say, captivating. And so is the book. The cover features colorful images of various birds—such as the ruby-throated hummingbird, the tufted coquette or the buff-tailed sicklebill—taken from one of the most impressive plates in Ernst Haeckel’s Kunstformen der Natur (Art Forms in Nature) and interlaced on ...