Search results for "EAD"

Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions

2020

Robust control of anterior-posterior axial patterning during regeneration is mediated by bioelectric signaling. However, a number of systems-level properties of bioelectrochemical circuits, including stochastic outcomes such as seen in permanently de-stabilized "cryptic" flatworms, are not completely understood. We present a bioelectrical model for head-tail patterning that combines single-cell characteristics such as membrane ion channels with multicellular community effects via voltage-gated gap junctions. It complements the biochemically-focused models by describing the effects of intercellular electrochemical coupling, cutting plane, and gap junction blocking of the multicellular ensemb…

Assessing autophagy in archived tissue or how to capture autophagic flux from a tissue snapshot

2020

This article belongs to the Special Issue Autophagy in Cancer.

Differential expression of the corticosteroid receptors GR1, GR2 and MR in rainbow trout organs with slow release cortisol implants

2012

The present study describes the transcriptional levels of the corticosteroid receptors (CRs) GR1, GR2 and MR in the different organs of the rainbow trout (Oncorhynchus mykiss) in response to a slow release of cortisol, throughout a 10-day period. We show that after short term (1 day after cortisol implantation), when the plasma levels of cortisol emulate an acute stress, the GR2 and MR expression levels were upregulated in the brain and head kidney tissues. This result reflects the role of these organs as regulators of the stress response. In general, the rest of the organs, especially gills, intestine, liver, muscle and spleen, showed decreased transcriptional levels of GR1, GR2 and MR, al…

Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidati…

2005

The two Sn(IV) complexes synthesized using calix[4]arene-1,3-di-acid derivative were characterized by analytical, 1H, 13C and 119Sn NMR, matrix assisted laser desorption ionization mass, and 119Sn Mossbauer techniques and found that the complexes are tetranuclear possessing structurally two different types of tin centers. These complexes were evaluated for their protective value against blood and tissue oxidative stress in lead exposed male albino rats of Wistar strain. The results suggest that the two tin complexes significantly protect changes in lead induced biochemical variables indicative of heme synthesis pathway and exhibit only moderate effect on tissue oxidative stress. The benefic…

Detection and mapping of "blue carbon" reservoir storage in Posidonia oceanica dead matte in front of an extensive industrial area

2015

The endemic Mediterranean seagrass Posidonia oceanica is the only marine phanerogam able to form matte, a biogenic structure representing important long-term “blue carbon” reservoir. Natural and/or anthropogenic factors can lead to the formation of a regressive structure, called “dead matte”, resulting from the disappearance of living shoots in the upper part of the matte. In the framework of TETIDE project (PON01_03112, www.progettotetide.it) a multiple sensors acoustic survey -multibeam sonar (MBS), side scan sonar (SSS), sub-bottom profiler (SBP) -was carried out in a portion of the Gulf of Augusta (Sicily, Southern Ionian Sea). The aim of investigation was to estimate the extent of dead…

Biodynamic behavior of the trunk and the abdomen during whole-body vibration

1989

Vibration strain may be defined as the sum of all reactions of the human being to vibration exposure. This also includes the biomechanical behavior of particular parts of the body. Knowledge about these reactions is necessary in the field of occupational health and ergonomics. Biomechanical models, experimental methods, and results are presented. It can be shown that under vibration exposure with different conditions (body posture, vibration direction), the body parts are in resonance at varying frequencies, mainly in a low frequency range.

La Europa social / 2. La Bolsa o lo social

2005

Emergence of statistically validated financial intraday lead-lag relationships

2014

According to the leading models in modern finance, the presence of intraday lead-lag relationships between financial assets is negligible in efficient markets. With the advance of technology, however, markets have become more sophisticated. To determine whether this has resulted in an improved market efficiency, we investigate whether statistically significant lagged correlation relationships exist in financial markets. We introduce a numerical method to statistically validate links in correlation-based networks, and employ our method to study lagged correlation networks of equity returns in financial markets. Crucially, our statistical validation of lead-lag relationships accounts for mult…

Development of peptidomimetic boronates as proteasome inhibitors.

2013

Abstract Proteasome inhibition has emerged over the past decade as an effective therapeutic approach for the treatment of hematologic malignancies. It is a multicatalytic complex, whose proteolytic activity relies in three types of subunits: chymotrypsin-like (β5), trypsin-like (β2) and caspase-like (β1). Most important for the development of effective antitumor agents is the inhibition of the β5 subunits. In this context, the dipeptide boronate bortezomib (Velcade ® ) represents the first proteasome inhibitor approved by the FDA and the lead compound in drug discovery. This paper describes the synthesis and biological evaluation of a series of conformationally constrained pseudopeptide bor…

Unsteady Separation and Navier-Stokes Solutions at High Reynolds Numbers

2010

We compute the numerical solutions for Navier-Stokes and Prandtl’s equations in the case of a uniform bidimensional flow past an impulsively started disk. The numerical approx- imation is based on a spectral methods imple- mented in a Grid environment. We investigate the relationship between the phenomena of unsteady separation of the flow and the exponential decay of the Fourier spectrum of the solutions. We show that Prandtl’s solution develops a separation singularity in a finite time. Navier-Stokes solutions are computed over a range of Reynolds numbers from 3000 to 50000. We show that the appearance of large gradients of the pressure in the stream- wise direction, reveals that the visc…