Search results for "EAI"

Reproducibility of Rolandic beta rhythm modulation in MEG and EEG

2022

The Rolandic beta rhythm, at ∼20 Hz, is generated in the somatosensory and motor cortices and is modulated by motor activity and sensory stimuli, causing a short lasting suppression that is followed by a rebound of the beta rhythm. The rebound reflects inhibitory changes in the primary sensorimotor (SMI) cortex, and thus it has been used as a biomarker to follow the recovery of patients with acute stroke. The longitudinal stability of beta rhythm modulation is a prerequisite for its use in long-term follow-ups. We quantified the reproducibility of beta rhythm modulation in healthy subjects in a 1-year-longitudinal study both for MEG and EEG at T0, 1 month (T1-month, n = 8) and 1 year (T1-ye…

Bērna dzimumneaizskaramības aizsardzības un dzimumnoziedznieka tiesību uz personas neaizskaramību līdzsvarošana

2016

Maģistra darbā tiek apskatīta šobrīd tik aktuālā seksuālās vardarbības problēma, kas vērsta pret vienu no neaizsargātākajām grupām sabiedrībā – bērnu, izvērtējot vai kastrācijas likuma ieviešana atrisinātu un mainītu dzimumnoziedznieka vērtības sistēmu, kā arī vai šāds tiesību aizskārums, ieviešot šo likumu, būs attaisnojams demokrātiskā sabiedrībā. Lai sasniegtu izvirzīto mērķi, maģistra darbā tiek aplūkots plašs starptautisko tiesību un nacionālo tiesību aktu klāsts, kā arī veikta Satversmē noteikto pamattiesību analīze, ņemot vērā nepieciešamību izvērtēt vai Latvijas tiesiskajā vidē ir nepieciešams šāds kastrācijas likums, kas ierobežotu dzimumnoziedznieka dzimumspēju. Tā kā bērna tiesīb…

Elinkeinoverorekisteriaineiston editointi ja imputointi : sovellettujen menetelmien vertailu

2001

Vasteajan vaikutus emotionaaliseen käyttäjäkokemukseen

2015

Vasteajan vaikutus käyttäjäkokemukseen on kiistaton, mutta vasteaikojen suhteesta käyttäjäkokemukseen ja varsinkin sen emotionaalisiin dimensioihin tarvitaan lisää tutkimustietoa. Lisäksi voimassa olevia suosituksia vasteajan sietokyvyn kynnysarvoista täytyy tarkastaa. Tämän tutkimuksen tavoitteena oli selvittää, millä tavoin matkapuhelin- ja työpöytäsovelluksien yhteydessä eri vasteajat vaikuttavat osaamisen, turhautumisen ja hallinnan tunteeseen. Tutkimuksen koehenkilöt suorittivat tuntikirjaustehtäviä sovelluksella, jonka käyttöliittymän vasteaikaa vaihdeltiin välittömän, 1 sekunnin ja 2 sekunnin välillä. Lisäksi sovelluksen tyyppiä, matkapuhelin- ja työpöytäsovellus, vaihdeltiin. Koehen…

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

2019

Beagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds. This study evaluated the glucuronidation characteristics of several 7-hydroxycoumarin derivatives in beagle dog's intestine and liver in vitro. To this end, glucuronidation rates of 7-hydroxycoumarin (compound 1), 7-hydroxy-4-trifluoromethylcoumarin (2), 6-methoxy-7-hydroxycoumarin (3), 7-hydroxy-3-(4-tolyl)coumarin (4), 3-(4-fluorophenyl)coumarin (5), 7-hydroxy-3-(4-hydroxyphenyl)coumarin (6), 7-hydroxy-3-(4-methoxyphenyl)coumarin (7), and 7-hydroxy-3-(1H-1,2,4-t…

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

2021

Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. Currently used CYP substrates, such as 7-ethoxycoumarin and 7-ethoxyresorufin, are oxidized by all individual CYP1 forms. The main aim of this study was to find profluorescent coumarin substrates that are more selective for the individual CYP1 forms. Eleven 3-phenylcoumarin derivatives were synthetized, their enzyme kinetic parameters were determined, and their interactions in the active sites of CYP1 enzymes were analyzed by docking and molecular dynamic simulations. All cou…

Los sexenios de investigación en Ciencias Sociales. Convocatoria 2016

2016

Presentación realizada en la Biblioteca de Ciències Socials de la Universitat de València y dirigida al personal docente e investigador en la que se presentan las principales novedades de la convocatoria de la CNEAI para la solicitud de los tramos de investigación para el año 2016. Se presenta asimismo el nuevo espacio del servicio de apoyo a la investigación: http://investsbd.blogs.uv.es

Older Age Increases the Amplitude of Muscle Stretch-Induced Cortical Beta-Band Suppression But Does not Affect Rebound Strength

2020

Healthy aging is associated with deterioration of the sensorimotor system, which impairs balance and somatosensation. However, the exact age-related changes in the cortical processing of sensorimotor integration are unclear. This study investigated primary sensorimotor cortex (SM1) oscillations in the 15–30 Hz beta band at rest and following (involuntary) rapid stretches to the triceps surae muscles (i.e., proprioceptive stimulation) of young and older adults. A custom-built, magnetoencephalography (MEG)-compatible device was used to deliver rapid (190°·s−1) ankle rotations as subjects sat passively in a magnetically-shielded room while MEG recorded their cortical signals. Eleven young (age…

Cortical networks show characteristic recruitment patterns after somatosensory stimulation by pneumatically evoked repetitive hand movements in newbo…

2022

Abstract Controlled assessment of functional cortical networks is an unmet need in the clinical research of noncooperative subjects, such as infants. We developed an automated, pneumatic stimulation method to actuate naturalistic movements of an infant’s hand, as well as an analysis pipeline for assessing the elicited electroencephalography (EEG) responses and related cortical networks. Twenty newborn infants with perinatal asphyxia were recruited, including 7 with mild-to-moderate hypoxic–ischemic encephalopathy (HIE). Statistically significant corticokinematic coherence (CKC) was observed between repetitive hand movements and EEG in all infants, peaking near the contralateral sensorimotor…

Välitilinpäätös digitaalisesta historiantutkimuksesta

2021

Kirja-arvostelu Mats Fridlund, Mila Oiva & Petri Paju (toim), Digital Histories: Emergent Approaches within the New Digital History, Helsinki University Press, 2020, 360 sivua, ISBN (PDF): 978-952-369-021-9, https://doi.org/10.33134/HUP-5