Search results for "ECK"
showing 10 items of 2091 documents
A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.
2014
Scope Resveratrol may function as a chemopreventive agent. A recent clinical study demonstrates a reduction in tumor cell proliferation in colorectal patients receiving repeated oral ingestion of resveratrol. However, gaps remain in our knowledge of the molecular mechanisms by which resveratrol exerts its chemopreventive effect. We have previously demonstrated that resveratrol induces apoptosis in colon cancer cells and that resveratrol can sensitize chemoresistant colon cancer cells to various drugs. Based on its ability to activate peroxisome proliferator-activated receptor gamma (PPARγ) in colon cancer cells, we sought to determine the implication of this nuclear transcription factor in …
RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development
2012
The Ras association domain family 1 isoform A (RASSF1A) is a tumor suppressor whose inactivation is implicated in the development of many human cancers, including breast carcinomas. Little is known about the tumor-suppressive function of RASSF1A in breast tissue and whether its inactivation is mechanistically involved in the initiation and progression of breast tumors. Here, we show that RASSF1A inhibits breast cancer growth in vivo, and suppresses estrogen receptor (ERα) expression and function. Reconstitution of RASSF1A in MCF7 cells led to decreased ERα levels and reduced sensitivity to estrogen (E2). Concomitantly, we observed decreased expression of Id1 as well as the E2-responsive gen…
Sterigmatocystin: Occurrence, toxicity and molecular mechanisms of action – A review
2020
The mycotoxin sterigmatocystin (STE) is produced mainly by Aspergillus fungi. It has been reported to occur in grains and grain-based products, cheese, coffee, spices and beer. The STE is a known biogenic precursor of aflatoxin B1, sharing with it several structural and biological similarities. The STE has been shown to be hepatotoxic and nephrotoxic in animals and it has been classified as possible human carcinogen (group 2B) by IARC. The STE has been reported to cause a marked decrease in cell proliferation in different mammalian cells. Data available on literature suggest that the cellular mechanisms underlying STE-induced toxicity include the induction of oxidative stress, mitochondrial…
Thermoelectrics: From history, a window to the future
2019
Thermoelectricity offers a sustainable path to recover and convert waste heat into readily available electric energy, and has been studied for more than two centuries. From the controversy between Galvani and Volta on the Animal Electricity, dating back to the end of the XVIII century and anticipating Seebeck’s observations, the understanding of the physical mechanisms evolved along with the development of the technology. In the XIX century Ørsted clarified some of the earliest observations of the thermoelectric phenomenon and proposed the first thermoelectric pile, while it was only after the studies on thermodynamics by Thomson, and Rayleigh’s suggestion to exploit the Seebeck effect for …
Electrochemical Synthesis of an Organic Thermoelectric Power Generator.
2020
[EN] Energy harvesting through residual heat is considered one of the most promising ways to power wearable devices. In this work, thermoelectric textiles were prepared by coating the fabrics, first with multiple-wall carbon nanotubes (MWCNTs) by using the layer-by-layer technique and second with poly(3,4-ethylenedioxythiophene) (PEDOT) deposited by electrochemical polymerization. Sodium deoxycholate and poly(diallyldimethylammonium chloride) were used as stabilizers to prepare the aqueous dispersions of MWCNTs. The electrochemical deposition of PEDOT on the MWCNT-coated fabric was carried out in a three-electrode electrochemical cell. The polymerization of PEDOT on the fabric increased the…
Hiperplasia epitelial focal: una rara enfermedad en nuestro medio
2005
La hiperplasia epitelial focal es una afección benigna asintomática y de muy baja frecuencia en nuestro medio. Aparece como pápulas en labio inferior principalmente, aunque se pueden localizar en mucosa retrocomisural y lengua y con menos frecuencia en labio superior, encía y paladar. Presentamos un caso clínico de una niña de 9 años, saharaui con lesiones que clínica e histológicamente se corresponden con una hiperplasia epitelial focal. Focal epithelial hyperplasia is a benign, asymptomatic disease, occurring with very low frequency within our population. It appears as papules, principally on the lower lip, although it can also be found on the retro-commissural mucosa and tongue, and less…
Hiperplasia multifocal del epitelio: Reporte de nueve casos
2005
La hiperplasia multifocal del epitelio (HME) conocida también como hiperplasia epitelial focal, enfermedad de Heck ó hiperplasia multifocal del epitelio por papiloma virus, se caracteriza por la aparición de lesiones múltiples en la mucosa de la cavidad bucal en población pediátrica y se asocia a la presencia del virus papiloma humano. El objetivo de este estudio fue conocer las características clínico-patológicas de los casos diagnosticados de esta enfermedad en el Servicio de Dermatología del Hospital Manuel Gea González. Se revisaron los archivos de esta institución y se seleccionaron los casos diagnosticados como HME. Se encontraron 9 casos. La mayoría de los pacientes fueron menores de…
Predictors of foster father’s engagement in foster family homes
2021
Tło badań: Ojcostwo zastępcze jest niewątpliwie szczególnym rodzajem ojcostwa, ponieważ mężczyzna, często będąc już mężem i ojcem swych biologicznych dzieci, podejmuje decyzję o odgrywaniu roli ojca zastępczego. Pełnienie roli ojca zastępczego wymaga wysokiego poziomu zaangażowania w realizację działań opiekuńczo-wychowawczych oraz kompensacyjnych, które z kolei wymagają ciągłego podnoszenia kompetencji w zakresie pracy z dzieckiem osieroconym. Cel badań: Poznanie czynników warunkujących poziom zaangażowania ojców zastępczych w realizację rodzicielskiej działalności w rodzinnych domach dziecka w wymiarze zarówno globalnym, jak i parcjalnym. Metoda badawcza: W badaniach zastosowano metodę so…
A Synopsis of the Genus Stipa (Poaceae) in Middle Asia, Including a Key to Species Identification, an Annotated Checklist, and Phytogeographic Analys…
2020
The genus Stipa L. comprises over 150 species, all native to the Old World, where they grow in warm temperate regions throughout Europe, Asia, and North Africa. It is one of the largest genera in the family Poaceae in Middle Asia, where one of its diversity hotspots is located. However, identification of Middle Asian Stipa species is difficult because of the lack of new, comprehensive taxonomic studies including all of the species recorded in the region. We present a critical review of the Mid-Asian representatives of Stipa, together with an identification key and taxonomic listing. We relied on both published and unpublished information for the taxa involved, many of which are poorly known…
Urīna analīzes savākšanas metodes ietekme uz tās rezultātu, pacientiem ar gūžas kaula kakliņa lūzumu
2016
Bakalaura darba tēma – Urīna analīžu savākšanas metodes ietekme uz tās rezultātu pacientiem ar ciskas kaula kakliņa lūzumu. Tēmas aktualitāti nosaka X traumatoloģijas profila stacionārā aktualizējusies problēma par bieži sastopamu urīnceļu infekciju pacientiem ar ciskas kaula kakliņa lūzumu. Darba autorei, konsultējoties ar stacionāra ārstiem, radās aizdomas ka šāda problēma rodas izvēloties nepareizu urīna analīzes savākšanas tehniku. Darba mērķis ir izpētīt un analizēt urīna analīzes parauga savākšanas metodes ietekmi uz tās rezultātu, pacientiem ar ciskas kaula kakliņa lūzumu Mērķa sasniegšanai tika izvirzīti vairāki uzdevumi – literatūras analīze, urīna paraugu savākšanas metožu apskats…