Search results for "ECL"
showing 10 items of 1262 documents
Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.
2021
Simple Summary The clinical efficacy of immunotherapies when treating cold tumors is still low, and different treatment combinations are needed when dealing with this challenging scenario. In this work, a middle-out strategy was followed to develop a model describing the antitumor efficacy of different immune-modulator combinations, including an antigen, a toll-like receptor-3 agonist, and an immune checkpoint inhibitor in mice treated with non-inflamed tumor cells. Our results support that clinical response requires antigen-presenting cell activation and also relies on the amount of CD8 T cells and tumor resistance mechanisms present. This mathematical model is a very useful platform to ev…
Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis
2020
Abstract Fingolimod is an approved treatment for relapsing–remitting multiple sclerosis (MS), and its properties in different pathways have raised interest in therapy research for other neurodegenerative diseases. Fingolimod is an agonist of sphingosine-1-phosphate (S1P) receptors. Its main pharmacologic effect is immunomodulation by lymphocyte homing, thereby reducing the numbers of T and B cells in circulation. Because of the ubiquitous expression of S1P receptors, other effects have also been described. Here, we review preclinical experiments evaluating the effects of treatment with fingolimod in neurodegenerative diseases other than MS, such as Alzheimer’s disease or epilepsy. Fingolimo…
Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease.
2000
Impairment of the central cholinergic system has a pivotal role in the cognitive decline observed in patients with Alzheimer’s disease (AD). One of the most prominent cholinergic deficits is the reduced number of nicotinic acetylcholine receptors (nAChR) in the brain. Since these receptors are important for memory and learning, enhancing nicotinic neurotransmission is a promising treatment strategy for AD. The two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE), or to mimic the effects of ACh (nicotinic agonists) by acting directly on nicotinic receptors. Clinical studi…
Computational Analysis of the Active Control of Incompressible Airfoil Flutter Vibration Using a Piezoelectric V-Stack Actuator
2021
The flutter phenomenon is a potentially destructive aeroelastic vibration studied for the design of aircraft structures as it limits the flight envelope of the aircraft. The aim of this work is to propose a heuristic design of a piezoelectric actuator-based controller for flutter vibration suppression in order to extend the allowable speed range of the structure. Based on the numerical model of a three degrees of freedom (3DOF) airfoil and taking into account the FEM model of a V-stack piezoelectric actuator, a filtered PID controller is tuned using the population decline swarm optimizer PDSO algorithm, and gain scheduling (GS) of the controller parameters is used to make the control adapti…
Studio di segmentazione morfovolumetrica in pazienti con declino cognitivo lieve amnestico (aMCI) e demenza di Alzheimer (AD) rispetto ad un gruppo d…
2016
SCOPO: Presentare i risultati preliminari di un’analisi di segmentazione morfovolumetrica (VBM) eseguita in pazienti con aMCI ed AD rispetto ad una popolazione di controllo (NAB). Tali dati saranno in futuro correlati ad altri parametri clinico-psicologici raccolti (età, sesso, scolarità, MMSE, ADL, IADL). MATERIALI E METODI: Sono stati sottoposti ad esame RM encefalo 103 soggetti, utilizzando uno scanner RM GE Signa HDxt da 1,5T ed acquisendo, tra le altre, una sequenza Sag 3D T1 FSPGR IR preped ASSET che è stata utilizzata per l’analisi VBM eseguita con il tool sienax (FSL). I risultati sono stati valutati in termini di valori medi e deviazioni standard mediante applicazione del t-test…
Is the painted frog Discoglossus pictus a declining species in Italy? On the reliability of a distributional atlas approach
2013
The conservation status of amphibians is often assessed using public databases because of a lack of up-to-date field data. However, it is crucial that this kind of data is used carefully, evaluating the reliability and the consistency of the information. In Italy, the conservation status of the painted frog, Discoglossus pictus, was recently assessed using public databases, and the outcome highlighted a worrying situation for the species. We analyzed the reliability of these conclusions and reassessed the status of the painted frog, taking into account its insular distribution and new data of species occurrence. Our results contrast with the previous analysis and show how an incautious use …
Synthesis and evaluation of 18F-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease
2010
Amyloid aggregates play a major role in the development of Alzheimer's disease. Targeting these aggregates by PET probes enables non-invasively the detection and quantification of amyloid deposit distribution in human brains. Based on benzothiazole core structure a series of amyloid imaging agents were developed. Currently [(11)C]2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (Pittsburgh Compound-B (PIB) is the most specific and widely used amyloid imaging ligand. But due to the short half life of (11)C, longer lived (18)F-labeled derivatives offer logistic advantages and higher contrast images. In this work, three different [(18)F]fluoroethoxy-substituted benzothiazole derivatives ([(18…
Counter-Clock World: How Planning Backwards Helps in Moving Forward in Collapsing Environments
2021
Research on corporate decline and turnarounds as well as the strategic use of history have so far remained two separate research fields. We integrate these two fields with a thought experiment, proposing ways in which strategists can work with, and through time in managing and turning around declines. Our thought experiment involves two very different types of analogies: a textual one from Philip K. Dick’s science fiction novels, on the one hand, and a visual one from Einsteinian relativity science, on the other hand. Inspired and informed by these different conceptualizations of the past and time, we develop four forms of backward strategizing to successfully manage a struggling corporatio…
"Un puente sobre el abismo", de Higinio Noja Ruiz (1932) : cultura libertaria y literatura pacifista de entreguerras
2021
El escritor, ensayista y militante anarquista Higinio Noja Ruiz publicó en 1932 la novela Un puente sobre el abismo en la Editorial Estudios de Valencia. En ella Noja abordó el tema de las guerras y la lucha contra ellas a través de su protagonista, Guillermo Arjona, un joven burgués mallorquín muy influido por su lectura de las novelas sobre la Primera Guerra Mundial y casi obsesionado con esta temática. Se analiza aquí en primer lugar la figura de Noja Ruiz (1994-1972), prolífico novelista social a la vez que ensayista y pensador libertario de las décadas de 1920 y 1930. La trayectoria de Noja es inseparable de la de la revista cultural y editorial libertaria valenciana Estudios (1928-193…
Synthesis and antioxidant evaluation of novel silybin analogues
2006
In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 microM, while the IC50 of quercetin (the reference compound) was 38.1 microM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals.