Search results for "ECL"
showing 10 items of 1262 documents
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
2004
Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
Effect of selected triterpenoids on chronic dermal inflammation.
1997
The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed.
DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents.
2019
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding the biochemical basis of mechanisms responsible for enzyme selectivity and antiproliferative effects has renewed the interest in antifolates for cancer chemotherapy and prompted the medicinal chemistry community to develop novel and selective human DHFR inhibitors, thus leading to a new generation of DHFR inhibitors. This work summarizes the mechanism of action, chemical, and anticancer profile of the DHFR inhibitors discovered in the last six years. New strategies in DHFR drug discovery are also provided, …
Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity
2021
The clinical utility of the chemotherapeutic drug cisplatin is significantly limited by its nephrotoxicity, which is characterized by electrolytic disorders, glomerular filtration rate decline, and azotemia. These alterations are consequences of a primary tubulopathy causing injury to proximal and distal epithelial cells, and thus tubular dysfunction. Oxidative stress plays a role in cisplatin nephrotoxicity and cytotoxicity, but its relative contribution to overall toxicity remains unknown. We studied the relation between the degree of oxidative reduction (provided by antioxidant treatment) and the extent of nephrotoxicity amelioration (i.e., nephroprotection) by means of a regression anal…
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
2004
BACKGROUND: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. OBJECTIVE: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. METHODS: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognit…
Apolipoprotein E polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation.
1996
Recent work provided evidence that the apolipoprotein (apo) E polymorphism is associated with late-onset sporadic Alzheimer's disease. The major histological hallmarks of Alzheimer's disease are the extraneuronal deposition of A4/beta-amyloid and the intraneuronal formation of neurofibrillary tangles, the latter correlating strongly with the psychometric status. We examined the relationship between the apo E polymorphism and Alzheimer's disease-related histological changes using a staging system which accounts for the progression of the disease over time and correlates well with the cognitive decline ante mortem. We observed a significant positive correlation between both neurofibrillary ch…
Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation.
1995
Only recently, evidence was provided that apolipoprotein E allele epsilon 4 located on Chromosome 19 is associated with late onset (i.e. senile) sporadic Alzheimer's disease. Histologically, Alzheimer's disease is associated with intraneuronal neurofibrillary changes and extraneuronal A4/beta-amyloid deposition. We set out with a histological staging system which considers the gradual development of Alzheimer's disease-related histological changes over time and correlates highly with the cognitive decline ante mortem. Our analysis revealed that both the mean stage for A4/beta-amyloid deposits and the mean stage for neurofibrillary tangles get significantly shifted upwards in epsilon 4-carri…
NOTES ON A STATUE FROM THE COLLECTIONS OF THE NATIONAL MUSEUM OF UNION FROM ALBA IULIA
2016
This study proposes to re-evaluate a marble statue from the old collections of the National Museum of Union Alba Iulia. It was discovered by A. Cserni during excavations carried out at the Palace of the Governors of Roman Dacia, in 1898. It has been repeatedly published by Á. Hekler and Al. Diaconescu. While the latter author established dating and iconographic prototype of the statue, we believe that further details as discovery place and context, depiction, iconographic attribution and role of this work of art can be offered. Presence of a follower at the feet of the divinity, more precisely the right foot of a character – child, conveys us the idea of depiction of Eros, god of love. Usua…
‘Adaptive cycles’ and climate fluctuations: a case study from Linear Pottery Culture in western Central Europe
2014
Abstract By applying cycle-based resilience theory the dynamics of the Early Neolithic west-central European Linear Pottery Culture (LBK) are investigated. These are interpreted as resulting from a combination of internal socio-economic processes as well as external environmental parameters. Resilience theory is helpful in understanding periods of increased vulnerability and inherent trends to social complexity. Cycles and threshold levels also help to understand why societies experience periods of increasing fragility and subsequent decline. Results are based on the correlation of a typology and dendrochronology-based archaeological chronology for western LBK and various palaeoclimatic pro…
Señor. El Cabildo de la Santa Iglesia Metropolitana de la Ciudad de Lima, en Sede-vacante ... dice: Que por el Testimonio de Autos remitido à V. Ma…
1731
Com a tít. el començament del text Caplletres ornades Sign.: A4 Reclams