6533b870fe1ef96bd12cfd97

RESEARCH PRODUCT

Effect of selected triterpenoids on chronic dermal inflammation.

José-luis RíosRosa-maría GinerMaría-carmen RecioSalvador Máñez

subject

Anti-Inflammatory AgentsDrug Evaluation PreclinicalInflammationPharmacologyDermatitis ContactDexamethasonechemistry.chemical_compoundMiceTriterpenoidDermisUrsolic acidTriterpeneEdemamedicineAnimalsOleanolic AcidBetulinic AcidDexamethasonePharmacologychemistry.chemical_classificationintegumentary systembusiness.industryTriterpenesmedicine.anatomical_structurechemistryImmunologyTetradecanoylphorbol AcetateFemalemedicine.symptombusinessPentacyclic Triterpenesmedicine.drug

description

The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed.

yearjournalcountryeditionlanguage
1997-09-01European journal of pharmacology
10.1016/s0014-2999(97)01187-4https://pubmed.ncbi.nlm.nih.gov/9346335