Search results for "ECL"
showing 10 items of 1262 documents
Public declarations and performing arts: the construction of characters and narratives of appropriators men and women in Teatro x la Identidad (2000-…
2020
El artículo se propone analizar los diferentes modos de poner en escena personajes y narrativas de apropiadores y apropiadoras en dos obras que formaron parte del primer ciclo de Teatro x la Identidad (Ciudad de Buenos Aires, 2001). Para esto, se estudiará la construcción de un represor y apropiador a través de sus declaraciones públicas reproducidas por la prensa escrita a fines de los años 80; y el uso dramático de aquellas declaraciones en el espectáculo semimontado A propósito de la duda (2000-2001), de Patricia Zangaro que lo convierte a él y a su esposa en personajes de apropiadores representados, irónicamente, como buenos padres de familia. Por otro lado, se examinará la obra Método …
Trajectory, Capital and Ideology. Perpetrators’ Statements on Trials for Crimes Against Humanity in Argentina
2020
Durante el juicio oral de la causa conocida como Guerrieri I que tuvo lugar en la ciudad de Rosario entre 2009 y 2010, cuatro de los cinco imputados hicieron uso de la palabra: el general (R) Pascual Guerrieri, subjefe del Destacamento de Inteligencia Militar 121 con sede en Rosario y comandante del “grupo de tareas”; el teniente coronel (R) Jorge Fariña, jefe operativo y de inteligencia del “grupo de tareas”; el capitán (R) Juan Daniel Amelong, subjefe del “grupo de tareas”; y el agente civil de inteligencia Eduardo “Tucu” Costanzo. La propuesta de este artículo es analizar el contenido de las declaraciones de los imputados a la luz de sus posiciones de enunciación en el contexto de copres…
Late-Victorian Paganism: the case of the Pagan Review
2015
Cet article traite de l’unique numéro de la Pagan Review paru en Grande-Bretagne en 1892 sous la seule plume de William Sharp, poète, critique littéraire et romancier qui devait par ailleurs rencontrer le succès sous le pseudonyme de Fiona MacLeod dès 1894. Rédigé à une époque de profonde réflexion personnelle par Sharp, la Pagan Review porte également l’empreinte du remaniement religieux et littéraire de la fin du siècle et témoigne de la recherche de l’expression littéraire d’une subjectivité revendiquant un certain syncrétisme religieux, l’égalité des sexes et le cosmopolitisme culturel. This article discusses the sole issue of the Pagan Review (1892) single-handedly authored by William …
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
2009
After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors, roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-di-chloropyrid-4-yl]-benzamide) may become the first agent in this class to be approved for patient treatment worldwide. Within the PDE family of 11 known isoenzymes, roflumilast is selective for PDE4, showing balanced selectivity for subtypes A-D, and is of high subnanomolar potency. The active principle of roflumilast in man is its dichloropyridyl N-oxide metabolite, which has similar potency as a PDE4 inhibitor as the parent compound. The long half-life and high potency of this metabolite allows for once-daily, oral administration of a single, 500…
Daratumumab for the Treatment of Multiple Myeloma
2018
This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.
Combining dasatinib with dexamethasone long-term leads to maintenance of antiviral and antileukemia specific cytotoxic T cell responses in vitro
2012
Maintaining graft versus leukemia (GvL) and antivirus responses of cytotoxic T cells (CTLs) while suppressing graft-versus-host disease (GvHD) remains a challenge after allogeneic bone marrow transplantation. Clinical observations indicate that combining glucocorticoids with multi-tyrosine-kinase inhibitors could be a successful therapeutic approach. We and others have shown that the BCR-ABL/SRC kinase inhibitor dasatinib may enhance or suppress T cells in vitro. In this report, we evaluated combination effects of dasatinib and dexamethasone on CD3 + and virus-specific CD8 + T cells directly ex vivo and on antigen-specific leukemia-reactive and alloreactive CD8 + T cell clones. Functional o…
P-selectin glycoprotein ligand-1 as a potential target for humoral immunotherapy of multiple myeloma.
2008
Monoclonal antibodies (mAbs), successfully adopted in the treatment of several haematological malignancies, have proved almost ineffective in multiple myeloma (MM), because of the lack of an appropriate antigen for targeting and killing MM cells. Here, we demonstrate that PSGL1, the major ligand of P-Selectin, a marker of plasmacytic differentiation expressed at high levels on normal and neoplastic plasma cells, may represent a novel target for mAb-mediated MM immunotherapy. The primary effectors of mAb-induced cell-death, complement-mediated lysis (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), were investigated using U266B1 and LP1 cell-lines as models. Along with immunolo…
BORRELIA BURGDORFERI SENSU LATO DETECTED IN SKIN OF NORWEGIAN MOUNTAIN HARES (LEPUS TIMIDUS) WITHOUT SIGNS OF DISSEMINATION
2011
The mountain hare (Lepus timidus) population in southern Norway appears to be in decline. Necropsy and laboratory examinations of 36 hares found dead or diseased during 2007-2009 in Vest- and Aust-Agder counties showed that disease and deaths were attributed to multiple causes, with no specific etiology emerging as a cause for population decline. To investigate whether Borrelia burgdorferi sensu lato (s.l.) infection is associated with mortality in mountain hares, tissues and ticks collected from hares were investigated for infection with the spirochete. Borrelia burgdorferi s.l. DNA was not detected in samples from internal organs, whereas Borrelia afzelii, B. burgdorferi sensu stricto (s.…
DO MARKERS OF PRECLINICAL ATHEROSCLEROSIS INFLUENCE GLOBAL CARDIOVASCULAR RISK?
2007
DO MARKERS OF PRECLINICAL ATHEROSCLEROSIS INFLUENCE GLOBAL CARDIOVASCULAR RISK?