Search results for "ECL"

The Ill-Fated Union: Constitutional Entrenchment of Rights and the Will Theory from Rousseau to Waldron

2014

This chapter revisits the key theses of Georg’s Jellinek’s Declaration of the Rights of Man and of Citizens: A Contribution to Modern Constitutional History [1895]. The objective of this chapter is to expose the ‘umbilical cord’ that linked the notion of ‘constitutional’ rights and the will theory, on one side, and the internal incompatibility of notion of ‘inalienable rights’ with the will theory – reflecting an unabated conflict of the doctrines of parliamentary supremacy and constitutional rights, on another side. These doctrines are part of both ‘continental’ and ‘common law’ traditions. Our intent is also to reflect on the shared groundwork of the doctrine of sovereignty of Hobbes, Aus…

Llamamiento internacional de Valencia / An international Appeal from Valencia

2008

Harnessing soft innovation resources leads to neo open innovation

2019

Advancement of the digital economy has transformed the concept of the growth crossover in nations and firms, both concerning input and output. Advanced economies have been confronting a dilemma between input increases and output decreases. Contrary to traditional expectations, excessive increase in input has resulted in a productivity decline in output. A solution to this dilemma can only be expected by harnessing the vigor of soft innovation resources that lead to neo open innovation in the digital economy. This paper attempts to demonstrate this hypothetical view. Based on an empirical analysis of the development trajectories of 140 countries and 500 global ICT firms, dynamism, resulting …

Assessment of soil suitability for improvement of soil factors and agricultural management

2019

The dramatic growth of the world&rsquo

Sorafenib perpetuates cellular anti-cancer effector functions by modulating the cross talk between macrophages and natural killer cells.

2012

Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor-directed natural killer (NK) cell responses. In vivo experiments were conducted with sorafenib (25 mg/kg)-treated C57BL/6 wildtype as well as hepatitis B virus (HBV) and lymphotoxin transgenic mice with and without HCC. Monocyte-derived Mϕ or tumor-associated macrophages (TAM) isolated from HCC tissue were treated with sorafenib (0.07-5.0 μg/mL) and cocultured with autologous NK cells. Mϕ and NK cell activation was analyzed …

Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed-mode liquid chromatography with quadrupole time-of-fligh…

2018

An analytical method based on liquid chromatography with quadrupole time-of-flight mass spectrometry has been developed for the simultaneous determination of six aminoglycoside antibiotics in honey. The sample pretreatment included extraction with aqueous trichloroacetic acid followed by solid-phase extraction on Strata-X polymeric reversed phase cartridges. Liquid chromatography separation was performed on an Obelisc R zwitterionic type mixed-mode column. An ionBooster™ heated electrospray source was used and showed enhanced ionization efficiency in comparison to a conventional electrospray source. The observed signal enhancement ranged from 3- (neomycin) to 16-fold (gentamicin C1). A data…

Lung Function Decline in Adult Asthmatics—A 10-Year Follow-Up Retrospective and Prospective Study

2021

Asthma may have an impact on lung function decline but conflicting results are reported in forced expiratory volume in one second (FEV1) decline. We aimed to describe the changes in FEV1 in lifelong non-smoking adult asthmatic outpatients during a 10-year follow-up comparing years 1–5 (1st period) with years 6–10 (2nd period) to assess factors affecting these changes. A total of 100 outpatients performed spirometry every 3 months during a 10-year survey. FEV1/Ht3 slope values of the 2nd period reduced significantly respect to the 1st period (p 1 slopes of years 1–5 and 6–10 were inversely associated with FEV1 at enrolment (p = 0.02, p = 0.01, respectively). Reversibility and variability FEV…

Funktionelle Bildgebung der Lunge mit gasförmigem Kontrastmittel: ³Helium-Magnetresonanztomographie

2005

Current imaging methods of the lung concentrate on morphology as well as on the depiction of the pulmonary parenchyma. The need of an advanced and more subtle imaging technology compared to conventional radiography is met by computed topography as the method of choice. Nevertheless, computed tomography yields very limited functional information. This is to be derived from arterial blood gas analysis, spirometry and body plethysmography. These methods, however, lack the scope for regional allocation of any pathology. Magnetic resonance imaging of the lung has been advanced by the use of hyperpolarised (3)Helium as an inhaled gaseous contrast agent. The inhalation of the gas provides function…

A possible solution of the puzzling variation of the orbital period of MXB 1659-298

2017

MXB 1659-298 is a transient neutron star Low-Mass X-ray binary system that shows eclipses with a periodicity of 7.1 hr. The source went to outburst in August 2015 after 14 years of quiescence. We investigate the orbital properties of this source with a baseline of 40 years obtained combining the eight eclipse arrival times present in literature with 51 eclipse arrival times collected during the last two outbursts. A quadratic ephemeris does not fit the delays associated with the eclipse arrival times and the addition of a sinusoidal term with a period of $2.31 \pm 0.02$ yr is required. We infer a binary orbital period of $P=7.1161099(3)$ hr and an orbital period derivative of $\dot{P}=-8.5(…

Multi-epoch VLTI-PIONIER imaging of the supergiant V766 Cen

2017

Context. The star V766 Cen (=HR 5171A) was originally classified as a yellow hypergiant but lately found to more likely be a 27-36 M red supergiant (RSG). Recent observations indicated a close eclipsing companion in the contact or common-envelope phase. Aims. Here, we aim at imaging observations of V766 Cen to confirm the presence of the close companion. Methods. We used near-infrared H-band aperture synthesis imaging at three epochs in 2014, 2016, and 2017, employing the PIONIER instrument at the Very Large Telescope Interferometer (VLTI). Results. The visibility data indicate a mean Rosseland angular diameter of 4.1 ± 0.8 mas, corresponding to a radius of 1575 ± 400 R. The data show an ex…