Search results for "EFA"

showing 10 items of 1142 documents

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

2016

Transmitted human immunodeficiency virus drug resistance in Europe is stable at around 8%. The impact of baseline mutation patterns on susceptibility to antiretroviral drugs should be addressed using clinical guidelines. The impact on baseline susceptibility is largest for nonnucleoside reverse transcriptase inhibitors.

MaleHuman immunodeficiency virus 1EtravirineRNA directed DNA polymerase inhibitordarunavirHIV InfectionsSettore MED/42 - Igiene Generale E Applicata:Disciplines and Occupations::Health Occupations::Medicine::Public Health [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Salud públicageneticsInhibidores de proteasas:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings]atazanavirmedia_commontransmission:Geographicals::Geographic Locations::Europe [Medical Subject Headings]3. Good healthmicrobial sensitivity testpriority journalEurope ; HIV-1 ; antiretroviral therapy ; drug resistance ; transmissionHIV/AIDSlamivudineReverse Transcriptase Inhibitors/pharmacologyanti human immunodeficiency virus agentDrugMicrobiology (medical)medicine.medical_specialtyantiviral susceptibility:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings]media_common.quotation_subjectantiretroviral therapy030106 microbiologyHIV Infections/drug therapy:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents::Reverse Transcriptase Inhibitors [Medical Subject Headings]Microbial Sensitivity TestsRILPIVIRINEArticleEFAVIRENZ03 medical and health sciencestransmitted drug resistanceSDG 3 - Good Health and Well-beingHumansTransmissionhuman:Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance [Medical Subject Headings]REVERSE-TRANSCRIPTASE INHIBITORSRilpivirinaINTEGRASEMUTATIONSabacavirmajor clinical studyVirologyInfecciones por VIHRegimenAntiretroviral therapy; Drug resistance; Europe; HIV-1; Transmission; Medicine (all); Microbiology (medical); Infectious DiseaseschemistryDrug resistance:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Oxazines::Benzoxazines [Medical Subject Headings]MutationHIV-10301 basic medicinenevirapineDrug resistanceCommunicable diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals [Medical Subject Headings]chemistry.chemical_compoundantiviral therapyINFECTIONMedicine and Health SciencesPrevalence:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings]ViralNon-U.S. Gov'tReverse-transcriptase inhibitorantiretrovirus agentResearch Support Non-U.S. Gov'tMedicine (all)Human immunodeficiency virus infected patientMiddle AgedvirologyPREVALENCEAntiretroviral therapyEncuestas y CuestionariosANTIRETROVIRAL TREATMENTEuropeInfectious DiseasesHIV-1/drug effectsHIV Protease Inhibitors/pharmacologyRilpivirineReverse Transcriptase Inhibitors:Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections [Medical Subject Headings]FemaleHIV drug resistancemedicine.drugAdultHuman immunodeficiency virus proteinase inhibitor:Chemicals and Drugs::Organic Chemicals::Nitriles::Rilpivirine [Medical Subject Headings]EfavirenzAnti-HIV AgentsResearch SupportResistencia a medicamentosSettore MED/17 - MALATTIE INFETTIVEantiviral resistanceInternal medicineAnti-HIV Agents/pharmacologyDrug Resistance ViralJournal Articlemedicine:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors [Medical Subject Headings]abacavir plus lamivudineEuropa (Continente)Antiretroviral therapy; Drug resistance; Europe; HIV-1; Transmission; Adult; Anti-HIV Agents; Drug Resistance Viral; Europe; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Prevalence; Reverse Transcriptase Inhibitors; Microbiology (medical); Infectious DiseasesemtricitabinenonhumanIntervalos de confianzadrug resistanceMutaciónAntiretroviral therapy; Drug resistance; Europe; HIV-1; Transmissionbusiness.industryHIVpredictionInhibidores de la transcriptasa inversaHIV Protease InhibitorsHuman immunodeficiency virus 1 infectiontenofovirINDIVIDUALSDrug Resistance Viral/geneticsBenzoxazinasETRAVIRINEdrug effects3121 General medicine internal medicine and other clinical medicinePrevalenciabusiness
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Stress in School. Some Empirical Hints on the Circadian Cortisol Rhythm of Children in Outdoor and Indoor Classes

2017

This prospective longitudinal survey compared the stress levels of students taught using an outdoor curriculum in a forest, with children in a normal school setting. We were especially interested in the effect outdoor teaching might have on the children’s normal diurnal cortisol rhythm. 48 children (mean age = 11.23; standard deviation (SD) = 0.46) were enrolled, with 37 in the intervention group (IG), and 11 in the control group (CG). The intervention consisted of one full school day per week in the forest over the school year. Stress levels were measured in cortisol with three samples of saliva per day. Furthermore, the data allowed for statistical control of physical activity (PA) values…

MaleHydrocortisoneHealth Toxicology and MutagenesisPoison controlphysical activitylcsh:Medicinefolkehelse010501 environmental sciences01 natural sciencesDevelopmental psychologystress0302 clinical medicineGermanyStress (linguistics)Longitudinal StudiesProspective Studies030212 general & internal medicineoutdoor learningChildProspective cohort studyMorningpublic healthCircadian RhythmCortisol rhythmFemalePsychologymedicine.drugPhysical activitykortisolEnvironmentcortisolArticlemixed effect model03 medical and health sciencesmedicineHumansCircadian rhythmSalivaStudents0105 earth and related environmental sciencesHydrocortisone:Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 [VDP]stress; cortisol; physical activity; outdoor learning; mixed effect modelTeachinglcsh:RPublic Health Environmental and Occupational Healthfysisk aktivitetLinear ModelsStress PsychologicalDemographyInternational Journal of Environmental Research and Public Health
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Efficacy of an insecticide paint against insecticide-susceptible and resistant mosquitoes - Part 1: Laboratory evaluation

2010

Abstract Background The main malaria vector Anopheles gambiae and the urban pest nuisance Culex quinquefasciatus are increasingly resistant to pyrethroids in many African countries. There is a need for new products and strategies. Insecticide paint Inesfly 5A IGR™, containing two organophosphates (OPs), chlorpyrifos and diazinon, and insect growth regulator (IGR), pyriproxyfen, was tested under laboratory conditions for 12 months following WHOPES Phase I procedures. Methods Mosquitoes used were laboratory strains of Cx. quinquefasciatus susceptible and resistant to OPs. The paint was applied at two different doses (1 kg/6 m2 and 1 kg/12 m2) on different commonly used surfaces: porous (cemen…

MaleInsecticideslcsh:Arctic medicine. Tropical medicineDiazinonMosquito ControlTime Factorslcsh:RC955-962PyridinesAnopheles gambiaeDrug Resistancelcsh:Infectious and parasitic diseasesToxicologychemistry.chemical_compoundInsect growth regulatorPaintAnimalslcsh:RC109-216biologyResearchbiology.organism_classificationFecunditySurvival AnalysisCulex quinquefasciatusMosquito controlCulexInfectious DiseaseschemistryChlorpyrifosDiazinonParasitologyFemaleChlorpyrifosPyriproxyfen
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DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

2014

Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether α-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.Methods. This was a prospective, multinational pharmacokinetic point-prevalence study including 8 α-lactam antibiotics. Two blood samples were taken from each patient during a single dosing interval. The primary pharmacokinetic/pharmacodynamic targets were free antibiotic concentrations above the minimum inhibitory concentration (MIC) of the pathogen at both 50% (50% f TMIC) an…

MaleInternational CooperationAntibioticsadverse eventintensive care unitlaw.invention0302 clinical medicinemeropenemModels[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesadverse events; continuous infusion; extended infusion; pharmacodynamics; pharmacokinetics; Aged; Anti-Bacterial Agents; Bacterial Infections; Blood Chemical Analysis; Female; Humans; Intensive Care Units; International Cooperation; Male; Microbial Sensitivity Tests; Middle Aged; Models Statistical; Prospective Studies; Treatment Outcome; beta-Lactams; Critical Illnessantibiotic therapyProspective Studiesamoxicillin plus clavulanic acidComputingMilieux_MISCELLANEOUSbeta lactam antibioticAPACHE0303 health sciencescritical illneadultclinical trial3. Good healthcontinuous infusion; extended infusion; adverse events; pharmacokinetics; pharmacodynamics.antiinfective agent[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitologypriority journaldisease severitybeta-Lactamstatistical model Agedprospective studyHumanMicrobiology (medical)medicine.medical_specialtydrug exposureCritical IllnessImmunologybloodstream infectionMicrobial Sensitivity Testspiperacillin plus tazobactambeta-LactamsMicrobiologybeta lactam abdominal infection03 medical and health sciencescritically ill patientIntensive careAnti-Bacterial AgentcefepimepharmacodynamicsHumansDosingAdverse effectAgedModels Statistical030306 microbiologyOdds ratiomajor clinical studymortalityantibiotic sensitivityceftriaxoneProspective Studiemulticenter studypharmacodynamics.ampicillinBlood Chemical AnalysisCeftazidimeSettore MED/41 - AnestesiologiaInterquartile rangelaw030212 general & internal medicinepharmacokineticlung infectionMicrobial Sensitivity TestarticleBacterial InfectionsMiddle AgedStatisticalcontinuous infusionIntensive care unitAnti-Bacterial Agentsextended infusionIntensive Care UnitsInfectious DiseasesTreatment Outcomeadverse events; continuous infusion; extended infusion; pharmacodynamics; pharmacokinetics; Aged; Anti-Bacterial Agents; Bacterial Infections; Blood Chemical Analysis; Female; Humans; Intensive Care Units; International Cooperation; Male; Microbial Sensitivity Tests; Middle Aged; Models Statistical; Prospective Studies; Treatment Outcome; beta-Lactams; Critical Illness; Microbiology (medical); Infectious Diseasescefazolin[SDV.IMM]Life Sciences [q-bio]/Immunologyblood samplingFemalepharmacokineticsmedicine.drugmedicine.drug_classprevalencedoripenemminimum inhibitory concentrationBacterial InfectionInternal medicinemedicinecontrolled studyblood analysibusiness.industryBlood Chemical Analysiadverse eventsSurgerypharmacodynamicdrug blood levelbusiness
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Health-related quality of life in adolescents with persistent pain and the mediating role of self-efficacy: a cross-sectional study

2020

Abstract Background Persistent pain has a high prevalence among adolescents. Pain has been shown to reduce all aspects of the adolescent’s health-related quality of life (HRQOL). In adult patients with pain, self-efficacy has been shown to mediate the relationship between pain intensity, disability and depression. However, little is known about whether self-efficacy acts as a mediating variable in the relationship between persistent pain and HRQOL sub-scale scores in a school-based population of adolescents. Objectives To describe the experience of pain, HRQOL and self-efficacy, and to explore the association between pain intensity, general self-efficacy and HRQOL in adolescents with persis…

MaleMediation (statistics)AdolescentVisual analogue scaleCross-sectional studyHealth-related quality of lifePopulationPsychological interventionAdolescentslcsh:Computer applications to medicine. Medical informaticsSeverity of Illness IndexHealth-related life quality03 medical and health sciences0302 clinical medicineQuality of lifeSurveys and QuestionnairesPersistent painHumansMedicine030212 general & internal medicineeducationPain MeasurementSelf-efficacyeducation.field_of_studyDepressionNorwaybusiness.industryResearchMediationPublic Health Environmental and Occupational HealthGeneral MedicineSelf EfficacyCross-Sectional StudiesMoodVDP::Medisinske Fag: 700::Helsefag: 800Quality of Lifelcsh:R858-859.7FemaleChronic PainSelf-efficacybusinessPersistent pains030217 neurology & neurosurgeryClinical psychologyHealth and Quality of Life Outcomes
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"I will never forget him". A qualitative exploration of staff descriptions of helpful relationships in supportive housing.

2020

WHAT IS KNOWN ON THE SUBJECT?: Recovery-oriented studies show that the quality of the professional relationship plays an essential role in the recovery from mental illness. Within mental health care in general, previous studies show that helpful professional relationships are characterized by several reciprocal aspects, such as friendship resemblance and self-disclosure. The literature is scarce on in-depth explorations of professional relationships within the often long-lasting and intimate help context of institutional supportive housing. Explorations of staff members' experiences are absent. The scientific rationale of this study was to expand the current knowledge about professional rel…

MaleMental Health Servicesmedia_common.quotation_subjectContext (language use)Personality Disorders03 medical and health sciences0302 clinical medicineReciprocity (social psychology)HumansQualitative Researchmedia_common030504 nursingConceptualizationbusiness.industryPublic relationsMental healthCommunity Mental Health Services030227 psychiatryFriendshipVDP::Medisinske Fag: 700::Helsefag: 800Ill-Housed PersonsSupportive housingHealth FacilitiesPshychiatric Mental HealthThematic analysis0305 other medical sciencebusinessPsychologyQualitative researchJournal of psychiatric and mental health nursingREFERENCES
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Adherence to a healthy and potentially sustainable Nordic diet is associated with child development in The Norwegian Mother, Father and Child Cohort …

2022

Abstract Background The rapid neurodevelopment that occurs during the first years of life hinges on adequate nutrition throughout fetal life and early childhood. Therefore, adhering to a dietary pattern based on healthy foods during pregnancy and the first years of life may be beneficial for future development. The aim of this paper was to investigate the relationship between adherence to a healthy and potentially sustainable Nordic diet during pregnancy and in early childhood and child development. Methods This study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa) and uses data from the Medical Birth Registry of Norway (MBRN). In 83,800 mother-child pairs, maternal p…

MaleNutrition and DieteticsNorwayMedicine (miscellaneous)MothersDietVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811Cohort StudiesFathersChild DevelopmentPregnancyChild PreschoolHumansFemale
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Differences in beliefs and home environments regarding energy balance behaviors according to parental education and ethnicity among schoolchildren in…

2014

Background To explore differences in personal and home environmental factors that are regarded as determinants of energy balance-related behaviors (EBRBs) according to parental education and ethnic background among 10–12 year old schoolchildren across Europe. Methods A school-based survey among 10–12 year olds was conducted in eight countries across Europe. A range of personal and home environment variables relevant for soft drink consumption, daily breakfast, sport participation and TV time was assessed by means of child report. Personal factors included attitude, health beliefs, and preference/liking. Home environment factors included parental subjective norm, modeling, support, practices…

MaleParentsGerontologyHealth Knowledge Attitudes PracticeBeliefsCross-sectional studyHealth BehaviorEthnic groupYOUNG-PEOPLECarbonated Beveragesbeliefs energy-balance behaviors ethnicity home environments parental education schoolchildrenMedicine and Health SciencesEthnicityMedicineChildCONSTRUCT-VALIDITY4. EducationPeer reviewEuropeSPORTS PARTICIPATIONVDP::Medisinske Fag: 700::Helsefag: 800Educational StatusFemaleTelevisionLIFE-STYLETEST-RETEST RELIABILITYCHILDHOOD OBESITYEnergy-balance behaviorsSportsResearch Articlemedicine.medical_specialtyParental educationSchoolchildrenChildhood obesityHumansSCHOOL-BASED INTERVENTIONSObesityExerciseDUTCH ADOLESCENTSBreakfastHome environmentsConsumption (economics)business.industryPublic healthPublic Health Environmental and Occupational HealthConstruct validitymedicine.diseaseCross-Sectional StudiesPHYSICAL-ACTIVITYWEIGHT STATUSBiostatisticsEnergy IntakebusinessDemography
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From cars to bikes : the effect of an intervention providing access to different bike types : a randomized controlled trial

2019

IntroductionWe aimed to investigate whether providing parents with children in kindergarten with access to different bicycle types could influence (i) travel behavior and cycling amount, and (ii) intrinsic motivation for cycling and psychological constructs related to car use.MethodsA randomized, controlled trial was conducted in Southern Norway from September 2017 to June 2018. In total 36 parents were recruited and randomly drawn into an intervention (n = 18) or control group (n = 18). The intervention group was in random order equipped with an e-bike with trailer (n = 6), a cargo (longtail) bike (n = 6) and a traditional bike with trailer (n = 6).ResultsAt follow-up, more participants fr…

MaleParentsIMPACTPoison controlSocial SciencesTransportationSuicide preventionlaw.inventionRandom orderHabitsFamilies0302 clinical medicineRandomized controlled triallawPsychologyMedicine030212 general & internal medicineMODEChildrenSchoolsMultidisciplinaryVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801NorwayQ05 social sciencesRACTIVE TRAVELVDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850SpringHEALTH-BENEFITSMedicineEngineering and TechnologyFemaleSeasonsCyclingBEHAVIORResearch ArticleAdultPsychometricsScienceeducationGREAT-BRITAINUNITED-STATESSELF-DETERMINATION03 medical and health sciencesIntervention (counseling)0502 economics and businessInjury preventionHumansExercise physiologyExerciseBehaviorMotivation050210 logistics & transportationbusiness.industryWinterCognitive PsychologyBiology and Life SciencesBICYCLEBicyclingPHYSICAL-ACTIVITYAge GroupsPeople and PlacesEarth SciencesCognitive SciencePopulation GroupingsbusinessAutomobileshuman activitiesNeuroscienceDemography
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Pain and health-related quality of life in adolescents and the mediating role of self-esteem and self-efficacy: a cross-sectional study including ado…

2021

Abstract Background To promote health-related quality of life (HRQOL) in adolescents with pain, it is important to study factors associated with pain. This study aimed to describe selected factors and pain in 14–15-year-old adolescents and their parents, to assess how these factors are associated with adolescent pain groups, and to explore whether the relationship between pain intensity and HRQOL in adolescents with persistent pain is mediated by self-esteem and self-efficacy. Methods A cross-sectional study was performed among 508 dyads of adolescents (14–15 years) and parents in a school-based setting. Among these, 148 adolescents had persistent pain. We explored the following variables: …

MaleParentsMediation (statistics)AdolescentCross-sectional studymedia_common.quotation_subjectHealth-related quality of lifePainHealth PromotionHealth-related life qualitiesAdolescentsQuality of lifeSurveys and QuestionnairesPersistent painSelf-esteemmedicineHumansPsychologyGeneral Psychologymedia_commonSelf-efficacyResilienceResearchPsychological researchMediationSelf-esteemLonelinessGeneral MedicinehumanitiesPeer reviewBF1-990Cross-Sectional StudiesVDP::Medisinske Fag: 700::Helsefag: 800Quality of LifeFemalemedicine.symptomPsychologySelf-efficacyPersistent painsClinical psychologyBMC Psychology
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