Search results for "EFFICACY"
showing 10 items of 588 documents
Problemi di giurisdizione nel contrasto al traffico di migranti via mare
2018
I trafficanti di esseri umani si avvalgono con sempre più insistenza di ben collaudati protocolli operativi. Questi ultimi consentono loro di sottrarsi alla giurisdizione penale italiana che non si radica qualora – in ossequio ai criteri di cui all’art. 6 c.p.ed in conformità alla Convenzione sull’Alto Mare– l’azione illecita avvenga in acque internazionali.Così, premesse alcune linee concettuali sui limiti spaziali alla efficacia della legge penale, l’indagine si sofferma sulla soluzione ermeneutica offerta dallaCassazione che, apparentemente in modo sbrigativo e per esigenze di effettività della risposta punitiva, ha fatto ricorso alla controversa figura dell’autore mediato per sanzionare condott…
Gestational surrogacy: Psychosocial aspects
2016
ABSTRACT Innovation in assisted reproductive technologies together with increased infertility and new family structures are increasing the use of gestational surrogacy as a means to have children. Before, during and after the process, it is necessary to study the psychosocial characteristics of triad members: the gestational surrogate, intended parents, and offspring. Research has indicated positive adaptation to the process and benefits for all members of the triad. Altruism is the main motivation of surrogates. Notably, psychological well-being has been found to be higher in individuals who have become parents through surrogacy than in those who have used egg donation or have followed a n…
The impact of senior management involvement, organisational commitment and group efficacy on ITIL implementation benefits
2014
Published version of an article from the journal: Information Systems and e-Business Management. Also available from Springerlink: http://dx.doi.org/10.1007/s10257-014-0253-4 Senior management involvement, organisational commitment and group efficacy are expected to have a positive impact on Information Technology Infrastructure Library (ITIL) implementation benefits. Specifically, more involvement, commitment and efficacy should produce greater achievement. Analysing data from a survey of 446 Nordic ITIL experts, this paper examines the relationships between these predictor factors and benefits, and investigates which is most critical. This study verifies the importance of all factors, but…
Demonstration as an aid to learning from animation
2017
Communication donnée le 1er septembre 2017 lors du symposium : Learning with dynamic media in formal and informal contexts (session K 26); International audience; The effectiveness of requiring learners to generate operational demonstrations while viewing an animation of a working mechanism was explored as a means of improving their animation processing. We assumed that the demonstration requirement would enhance learner extraction of key dynamic information needed for building a high quality mental model. It is expected that compared with note-taking controls, those in the demonstration group will give more attention to the spatiotemporal relationships amongst the mechanism’s components. T…
Il pensiero linguistico nella Grecia arcaica e classica
2016
Il saggio è un'analisi delle principali idee sul linguaggio nel pensiero greco arcaico e classico (da Omero ad Aristotele) con particolare riferimento alla tematica del rapporto tra verità ed efficacia. The paper is a study of the main ideas on language in ancient Greek thought (from Homer to Aristotle) with a particular focus on the relationship between truth and efficacy.
Grandmother cells: much ado about nothing
2016
International audience; We do not dispute the possibility of the existence in the brain of “grandmother cells”, which are very finely tuned neurons that fire only in the presence of specific objects or categories. However, we question the causal efficacy of such neurons at the functional or behaviour level. We claim that, even though very familiar items, such as “my grandmother”, may well have associated grandmother neurons, these neurons have very little, or no impact on the actual recognition of my grandmother. A study by Thomas, Van Hulle, and Vogels [(2002). Encoding of categories by noncategory-specific neurons in the inferior temporal cortex. Journal of Cognitive Neuroscience, 13, 190…
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
2021
[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 77…
Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: a meta-analysis of individual patient data
2004
Multicenter randomized trials have shown that once-weekly pegylated interferon (peginterferon) alfa-2a is more efficacious than conventional interferon alfa-2a (IFN) in patients with chronic hepatitis C. We performed a meta-analysis of 1,013 previously untreated patients (from 3 randomized trials) with pretreatment and post-treatment liver biopsies to assess the differences between peginterferon alfa-2a and IFN in terms of their effects on liver histology. Reported values were standardized mean differences (SMD) between patients receiving peginterferon alfa-2a and those receiving IFN (post-treatment value minus baseline value for each group). We used a random-effects model to quantify the a…
High efficacy and safety of triple therapy in HCV genotype 1 and moderate fibrosis: a multicenter study of clinical practice in Spain.
2015
Background and rational. Telaprevir-based therapy (TBT) has been extensively evaluated in clinical trials. So we designed a study to compare the efficacy and safety of TBT between patients with moderate fibrosis and those suffering from advanced fibrosis in clinical practice. A multicenter observational and ambispective study was conducted. It included 582 patients with chronic hepatitis C genotype 1, 214 with fibrosis F2, and 368 with F3/F4 (F3: 148; F4: 220). Results. The mean patient age was 55 years, 67% male. Type of prior response was 22% naive, 57% relapsers, and 21% partial/null responders, 69% had high viral load (> 800,000 IU/mL). HCV genotypes were 1a (19%), 1b (69%), and 1 (12%)…
Predictors of serious adverse events and non-response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid
2022
Background & Aims Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with "advanced cirrhosis" because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy. Methods Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs). Results One hundred PBC cirrhotics were included, 97…