Search results for "EFT"

Heredity and obesity-associated hypertension:impact on hormonal characteristics and left ventricular mass.

1995

Sacubitril/valsartan reduces indications for arrhythmic primary prevention in heart failure with reduced ejection fraction: insights from DISCOVER-AR…

2021

Abstract Aims This sub-study deriving from a multicentre Italian register [Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril-Valsartan: A Multicenter Echocardiographic Registry (DISCOVER)-ARNI] investigated whether sacubitril/valsartan in addition to optimal medical therapy (OMT) could reduce the rate of implantable cardioverter-defibrillator (ICD) indications for primary prevention in heart failure with reduced ejection fraction (HFrEF) according to European guidelines indications, and its potential predictors. Methods and results In this observational study, consecutive patients with HFrEF eligible for sacubitril/valsartan from 13 Italian centres were included. Lack o…

Supersymmetric SO(10)-inspired GUTs with sliding scales

2013

We construct lists of supersymmetric models with extended gauge groups at intermediate steps, all of which are inspired by SO(10) unification. We consider three different kinds of setups: (i) the model has exactly one additional intermediate scale with a left-right (LR) symmetric group; (ii) SO(10) is broken to the LR group via an intermediate Pati-Salam scale; and (iii) the LR group is broken into SU(3)(c) X SU(2)(L) X U(1)(R) X U(1)(B-L), before breaking to the standard model (SM) group. We use sets of conditions, which we call the "sliding mechanism," which yield unification with the extended gauge group(s) allowed at arbitrary intermediate energy scales. All models thus can have new gau…

Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling

2016

Background Ascending thoracic aortic aneurysm ( ATAA ) is driven by angiotensin II (Ang II ) and contributes to the development of left ventricular ( LV ) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments Ang II ‐induced abdominal aortic aneurysms in apolipoprotein E–deficient mice. We hypothesized that locally synthesized leptin mediates Ang II ‐induced ATAA . Methods and Results Following demonstration of leptin synthesis in samples of human ATAA associated with different etiologies, we modeled in situ leptin expression in apolipoprotein E–deficient mice by applying exogenous leptin on the surface of the ascending aorta. This treatm…

FFR for a Lesion in the Left Main: No One Is So Blind As Those Who Will Not See

2016

This case emphasizes the usefulness of FFR to assess the functional significance of an angiographically “intermediate” left main stem stenosis.

From Adjectives to Quantifiers. Evidence from Old and Modern Catalan

2011

La història dels quantificadors indefinits de les llengües romàniques és la història del desenvolupament de nous trets distribucionals per un grup escollit d’adjectius llatins (Company 1991, 1997; Batllori 1998). Aquesta distribució serà responsable de la constitució posterior de la nova subclasse de determinants que anomenem quantificadors. Com s’explica a Zamparelli (2000), l’augment de la complexitat estructural del marge esquerre del SDet suposa l’especialització de paraules que pertanyien a antigues categories per aquestes noves posicions. És així com la posició de quantificador genera la categoria quantificador. Estem devant un procés de llarga durada amb conseqüències que encara són …

Color Doppler Ultrasound in Portal Hypertension

2020

Portal hypertension is one of the most important causes of morbidity and mortality in cirrhotic patients. A color Doppler evaluation of the left gastric vein (LGV) has proven utility in the prediction of esophageal varices and variceal bleeding in patients with portal hypertension. The purpose of this review is to discuss the ultrasound evaluation, imaging findings, and clinical application of Doppler ultrasound in the assessment of the LGV. Knowledge of the color Doppler technique and imaging findings of the LGV may help clinicians improve the monitoring of portal hypertension and predict patients with a high risk of esophageal varices.

The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation

2018

OBJECTIVE: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.BACKGROUND: The exponential growth of laparoscopic liver surgery in recent years mandates the development of clinical practice guidelines to direct the speciality's continued safe progression and dissemination.METHODS: A unique approach to the development of clinical guidelines was adopted. Three well-validated methods were integrated: the Scottish Intercollegiate Guidelines Network methodology for the assessment of evidence and development of guideline statements; th…

Kontrastmittelverstärkte 3D-MR-Perfusion der Lunge: Einsatz paralleler Bildgebungstechniken bei gesunden Probanden

2004

PURPOSE Evaluation of lung perfusion by contrast-enhanced 3D MRI using partial parallel imaging techniques. MATERIALS AND METHODS Eight healthy volunteers were examined using a contrast-enhanced dynamic FLASH 3D sequence with partial parallel imaging technique at 1.5 T MRI with a TA of 1.5 sec. The whole lung was covered by 36 coronal slices. A ventral, middle and dorsal slice of each lung was manually segmented and signal-to-time curves were computed. For absolute quantification of blood flow through the right and left pulmonary artery, phase-contrast flow measurements were performed. RESULTS No significant difference was found between the signal intensity in the right (8.9 +/- 2.6) and le…

Activation of Cardiac c-Jun NH 2 -Terminal Kinases and p38-Mitogen–Activated Protein Kinases With Abrupt Changes in Hemodynamic Load

2001

Abstract —The role of mitogen-activated protein kinase (MAPK) pathways as signal transduction intermediates of hemodynamic stress leading to cardiac hypertrophy in the adult heart is not fully established. In a rat model of pressure-overload hypertrophy, we examined whether activation of MAPK pathways, namely, the extracellular signal–regulated protein kinase (ERK), c-Jun NH 2 -terminal kinase (JNK), and the p38-MAPK pathways, occurs during rapid changes in hemodynamic load in vivo. A slight activation of ERK2 and marked increases in JNK1 and p38-MAPK activities were observed 30 minutes after aortic banding. The increase in p38-MAPK activity was accompanied by an increase in the phosphoryl…