Search results for "ELI"

Metrological Properties of the Test Setup for Determination Shielding Effectiveness of the Industrial Cable Connectors

2017

Abstract The paper presents results related to assessment of the repeatability and reproducibility of the measurement test setup for determination the relative value of the shielding effectiveness coefficient of the industrial connectors. The construction of the proposed test setup, the measurement method and the procedure for the analysis of measurement results were described. To determine the value of the repeatability and reproducibility coefficient, the two–way analysis of variance was used, which additionally allows for an assessment of the influence of individual sources of variance. The measurements and their analysis were conducted for several frequencies in the range up to 1 GHz. A…

Contrasting topologies for regular interconnection networks under the constraints of nanoscale silicon technology

2010

Nowadays, system designers have adopted Networks-on-Chip as communication infrastructure of general-purpose tile-based Multi-Processor System-on-Chip (MPSoC). Such decision implies that a certain topology has to be selected to efficiently interconnect many cores on the chip. To ease such a choice, the networking literature offers a plethora of works about topology analysis and characterization for the off-chip domain. However, theoretical parameters and many intuitive assumptions of such off-chip networks do not necessarily hold when a topology is laid out on a 2D silicon surface. This is due to the distinctive features of silicon technology design pitfalls. This work is a first milestone t…

Lieux de culte dans l'Est de la Gaule : la place des sanctuaires dans la cité

2009

International audience; “Incubo”, an inventory of places of worship in ancient Burgundy, deals with the territories of Lingons and Éduens. This inventory already includes approximately one hundred completed index cards intended for publication. Three sites are presented here: an administrative city center, Autun (Saône-et-Loire), and two secondary cities, Vertault (Côte-d’Or) and Pierre-de-Bresse (Saône-et-Loire). These cases are representative of the different types of places of worship found in the region under investigation, but also of the various documentary states on which our inventory is based. Our object is to illustrate the potential of the Burgundian corpus and to evoke some prob…

Review of the PEA Method for Space Charge Measurements on HVDC Cables and Mini-Cables

2019

This review takes into account articles and standards published in recent years concerning the application of the Pulsed Electro Acoustic (PEA) method for space charge measurement on High Voltage Direct Current (HVDC) cables and mini-cables. Since the 80s, the PEA method has been implemented for space charge measurements on flat specimens in order to investigate space charge phenomena and to evaluate the ageing of dielectrics. In recent years, this technique has been adapted to cylindrical geometry. Several studies and experiments have been carried out on the use of the PEA method for full size cables and HVDC cable models. The experiments have been conducted using different arrangements of…

The ensemble switch method and related approaches to obtain interfacial free energies between coexisting phases from simulations: a brief review

2015

The accurate estimation of the excess free energy due to an interface between coexisting phases of a model system by computer simulation often is a challenging task. We review here two methods, whi...

Laser-induced enhancement of tunneling in NHD2

2012

We apply and explore techniques aiming at enhancing the tunneling by laser fields, originally developed for a one-dimensional model, to a complete six-dimensional vibrational model of the inversion motion in NHD(2). The computational study is performed with the multi-configuration time-dependent Hartree method. Assuming an ideal three-dimensional alignment we obtain a driven tunneling time twenty times smaller than the natural one, in rather good agreement with an oversimplified three-state model. In the case of one-dimensional alignment, a linearly polarized field leads to a poor enhancement of the tunneling probability, after averaging over the rotation about the alignment axis, whereas a…

Gold/Isophorone Interaction Driven by Keto/Enol Tautomerization

2016

The binding behavior of isophorone (C9H14O) to Au adatoms and clusters deposited on MgO/Ag(001) thin films is investigated by scanning tunneling microscopy (STM) and density functional theory (DFT). The STM data reveal the formation of various metal/organic complexes, ranging from Au1/isophorone pairs to larger Au aggregates with molecules bound to their perimeter. DFT calculations find the energetically preferred keto-isophorone to be unreactive toward gold, while the enol-tautomer readily binds to Au monomers and clusters. The interaction is governed by electrostatic forces between the hydroxyl group of the enol and negative excess charges residing on the ad-gold. The activation barrier b…

Exploring the Chemoselectivity towards Cysteine Arylation by Cyclometallated Au III Compounds: New Mechanistic Insights

2020

To gain more insight into the factors controlling the efficient cysteine arylation by cyclometalated Au(III) complexes, the reaction between selected gold compounds and different peptides was investigated by high‐resolution liquid chromatography electrospray ionization mass spectrometry (HR‐LC‐ESI‐MS). The deducted mechanisms of C–S cross‐coupling, also supported by density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced the key role of secondary peptidic gold binding sites in favouring the process of reductive elimination.

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

2020

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…

2020

Teraryl-based alpha-helix mimetics have resulted in efficient inhibitors of protein-protein interactions (PPIs). Extending the concept to even longer oligoarene systems would allow for the mimicking of even larger interaction sites. We present a highly efficient synthetic modular access to quateraryl alpha-helix mimetics, in which, at first, two phenols undergo electrooxidative dehydrogenative cross-coupling. The resulting 4,4′-biphenol is then activated by conversion to nonaflates, which serve as leaving groups for iterative Pd-catalyzed Suzuki-cross-coupling reactions with suitably substituted pyridine boronic acids. This work, for the first time, demonstrates the synthetic efficiency of …