Search results for "EMAS"
showing 10 items of 694 documents
Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy
2019
[EN] Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of this study were to analyze the molecular profile as well as the microsatellite status in a series of advanced colorectal patients from two public hospitals from Paraguay, to introduce these methodologies in the routine practice to guide the therapeutic decisions. Thirty-six patients diagnosed with advanced colorectal cancer from two referent public hospitals from Paraguay were recruited from May 2017 to February 2018. Sequenom Mass spectrometry, On…
Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone
2017
ABSTRACT : The global spread of Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase (KPC) has been mainly associated with the dissemination of high-risk clones. In the last decade, hospital outbreaks involving KPC-producing K. pneumoniae have been predominantly attributed to isolates belonging to clonal group (CG) 258. However, results of recent epidemiological analysis indicate that KPC-producing sequence type (ST) 307, is emerging in different parts of the world and is a candidate to become a prevalent high-risk clone in the near future. Here we show that the ST307 genome encodes genetic features that may provide an advantage in adaptation to the hospital environment and t…
Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging
2018
International audience; The N-methyl-D-Aspartate glutamate receptors (NMDARs) are pivotal for the functional and morphological plasticity that are required in neuronal networks for efficient brain activities and notably for cognitive-related abilities. Because NMDARs are heterogeneous in subunit composition and associated with multiple functional regulatory sites, their efficacy is under the tonic influence of numerous allosteric modulations, whose dysfunction generally represents the first step generating pathological states. Among the enzymatic candidates, serine racemase (SR) has recently gathered an increasing interest considering that it tightly regulates the production of D-serine, an…
Detection of two simultaneous outbreaks of Klebsiella pneumoniae coproducing OXA-48 and NDM-1 carbapenemases in a tertiary-care hospital in Valencia,…
2020
Klebsiella pneumoniae is one of the most common hospital-acquired Gram-negative pathogens. During the last decade, the emergence of strains with reduced susceptibility or resistance to carbapenems is becoming a therapeutic challenge. This study takes place after the isolation of 14 strains of carbapenem-resistant K. pneumoniae with similar susceptibility patterns and carriage of OXA-48 and NDM-1 carbapenemases genes. Fourteen patients were found to be colonized (faecal carriage) and/or infected by two different clones of carbapenemase-coproducing K. pneumoniae during a 1-year period of time. Some of the patients had shared a hospital ward and continued to be colonized several months after t…
Shortened Activated Partial Thromboplastin Time May Help in Diagnosing Hereditary and Acquired Angioedema
2016
<b><i>Objective:</i></b> To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. <b><i>Methods:</i></b> In a prospective investigation, APTT and other coagulation parameters were determined in 149 adult patients with various types of angioedema and in 26 healthy participants (HP). <b><i>Results:</i></b> Mean APTT was significantly shortened in HAE-C1-INH type I (p < 0.0001) and type II (p = 0.0017) and in AAE-C1-INH (p < 0.0001) compared to the HP. APTT was shorten…
A Tool to Assess Architectural Education from the Sustainable Development Perspective and the Students' Viewpoint
2021
[EN] Architectural education plays a fundamental role in achieving sustainable development by training future professionals who can contribute to sustainability through their practice. Nevertheless, to ensure the introduction of sustainable development in the education of future architects, it is fundamental to understand what is being done and what could be improved. Despite this, a big gap has been detected in the assessment of architectural education in Spain and worldwide. Thus, a close-ended questionnaire for students has been designed based on the outcomes from a literature review, exploratory interviews with specialists, and the qualitative analysis of two schools of architecture. Ad…
La cuestión del reconocimiento en América Latina. Perspectivas y problemas de la teoría político-social de Axel Honneth
2018
La investigación marxista hoy. Un balance sobrelas temáticas y problemas teóricos en torno al pensamiento y obra de Marx en su 200 aniversario
2018
Design and synthesis of optical sensors for the detection of molecules with biological activity
2015
A la present tesi doctoral, titulada “Disseny i síntesi de sensors òptics per a la detecció de molècules amb activitat biològica”, s’han utilitzat diferents conceptes de la química supramolecular per a preparar compostos capaços de senyalitzar macroscópicament la presència de molècules tòxiques o actives biològicament. Així, s’han preparat quimio-sensors i quimiodosímetres per a la detecció d’anions, sals, zwitterions i agents de guerra química tal i com agents nerviosos i agents sanguinis. Addicionalment, es descriu el disseny i la construcció d’un aparell electrònic per a la monitorització automàtica d’aquests compostos. La tesi té un capítol introductori on s'expliquen els conceptes bàsi…
Consolidación de zonas húmedas litorales de la Comunidad Valenciana como lugares de Educación Ambiental y de interés turístico sostenible
2019
En este trabajo convergen tres grandes áreas de Investigación: la Educación Ambiental, el ocio o turismo en el medio natural y el estudio de las zonas de humedal litoral desde una perspectiva ecológica. La unión de estos tres ejes ha tenido como resultado un trabajo con marcado carácter interdisciplinar, que persigue fomentar el estudio y puesta en práctica de actividades formativas, para alumnos de secundaria en lugares de alta sensibilidad ecológica como la zona de estudio en particular (Marjal del Moro) y los humedales litorales o marjales en general, así como actividades de ocio respetuosas y sostenibles con su frágil entorno. Para conseguir el citado objetivo, se ha realizado una inves…