Search results for "EMBER"
showing 10 items of 549 documents
Mārketinga komunikācijas pielietojums auditorijas piesaistei: internetveikalu "AboutYou" un "Membershop" piemēri
2021
Bakalaura darba tēma ir “Mārketinga komunikācijas pielietojums auditorijas piesaistei: internetveikalu “AboutYou” un “Membershop” piemēri". Bakalaura darba ietvaros tiek izpētīts, kāds ir mārketinga komunikācijas pamatuzdevums, kuri mārketinga rīki ir veiksmīgākie, lai piesaistītu auditoriju. Kā arī tiek izanalizēts, cik efektīvs ir internetveikalu “AboutYou” un “Membershop” mārketinga komunikācijas pielietojums auditorijas piesaistei Latvijas tirgū. Darba ietvaros teorētiskajā daļā tiek apskatīta informācija par tēla veidošanu, patērētāju pieņēmumu veidošanos, digitālo mārketingu, mārketinga komunikācijas veidiem, uzņēmuma komunikāciju un sociālajiem tīkliem, jo tie ir kanāli caur kuriem l…
Józef Wacław Dąbrowski (1797–1862). Wołynianin w armii Królestwa Polskiego
2021
W artykule, w oparciu o nieznane i tym samym niewykorzystywane dotąd przez historyków wspomnienia, przedstawione zostały dzieciństwo i młodość Józefa Wacława Dąbrowskiego, oficera wojska Królestwa Polskiego, dowódcę w randze kapitana i majora oddziałów powstańczych jesienią 1830 – latem 1831 r. Koleje jego losów i kariera wojskowa są tak typowe, jak i odbiegające od znanych i omawianych w literaturze przedmiotu schematów. Typowe, gdyż dzięki wywodzeniu się z kręgów średnio zamożnego ziemiaństwa rozpoczął służbę wojskową od stopnia kadeta, aby przed upływem roku awansować na podchorążego i uzyskać skierowanie do szkoły podchorążych, stanowiącej niezbędny etap służby potrzebny do awansu ofice…
The phylogenetic relationships of Przevalski's FinchUrocynchramus pylzowi, the most ancient Tibetan endemic passerine known to date
2016
Competing systematic hypotheses have placed the Tibetan endemic Przevalski's Finch Urocynchramus pylzowi either with the Old World buntings (Emberizidae) or with the cardueline finches (Fringillidae, Carduelinae). Recent studies based on limited genetic evidence instead suggest an isolated position within Passeroidea and advocate a separate family, Urocynchramidae, as had been suggested much earlier on the grounds of morphology. We provide a time-calibrated multi-locus phylogeny for Passeroidea including Przevalski's Finch based on three mitochondrial markers and three nuclear introns that placed U. pylzowi in a clade together with Estrildidae, Viduidae and Ploceidae. A sister group relatio…
Stable isotopes reveal differences in diet among reed bunting subspecies that vary in bill size
2017
Reed bunting Emberiza schoeniclus subspecies vary considerably in bill size and shape and seem to be at an early stage of speciation, in which bill might be indirectly causing reproductive isolation. Hence, we evaluated whether bill size, as well as age and sex, are associated with foraging niche in three west European subspecies of reed bunting: the thin-billed schoeniclus, the intermediate-billed lusitanica and the thick-billed witherbyi. Blood sampling was undertaken at three sites in southwest Europe during the winter (when these subspecies co-occur), and stable isotope analyses (carbon and nitrogen) were performed to assess their foraging niches. Stable isotope analyses of potential fo…
Phenotypic Divergence among West European Populations of Reed Bunting Emberiza schoeniclus: The Effects of Migratory and Foraging Behaviours
2013
[EN] Divergent selection and local adaptation are responsible for many phenotypic differences between populations, potentially leading to speciation through the evolution of reproductive barriers. Here we evaluated the morphometric divergence among west European populations of Reed Bunting in order to determine the extent of local adaptation relative to two important selection pressures often associated with speciation in birds: migration and diet. We show that, as expected by theory, migratory E. s. schoeniclus had longer and more pointed wings and a slightly smaller body mass than the resident subspecies, with the exception of E. s. lusitanica, which despite having rounder wings was the s…
Measuring environmental performance in the treatment of municipal solid waste: The case of the European Union-28
2021
Abstract This paper proposes a measure of environmental performance in the treatment of municipal solid waste, which is defined as a ratio between a composite indicator of waste treated through environmentally desirable operations –recycling and recovery in our case study– and a composite indicator of waste treated through undesirable operations –landfill and incineration. Moreover, it contributes both overall and treatment-specific indicators of performance. Data Envelopment Analysis (DEA) techniques are used to compute the environmental performance indicators and they are illustrated with an empirical assessment of the environmental performance of the European Union-28 (EU-28) members in …
Stabilization of an enzymatic extract from Penicillium camemberti containing lipoxygenase and hydroperoxide lyase activities
2008
International audience; The stabilization of an enzymatic extract, obtained from Penicillium camemberti containing lipoxygenase (LOX) and hydroperoxide lyase (HPL) activities, was investigated using selected additives. Although the addition of KCl (86%, w/w) to the enzymatic extract decreased slightly (7%) the LOX activity, it increased HPL activity by 2.25 fold; however, the addition of dextran resulted in the inactivation of both enzymatic activities. The stability of the solid lyophilized enzymatic extract was greater in the presence of KCl than that without it, with ∼100% residual activity after 8 and 4 weeks of storage at −80 °C, for LOX and HPL, respectively. The rate constants of ina…
Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-fa…
2016
AbstractWe systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed in vitro. RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed. Chromosomal aberrations were identified by array-comparative genomic hybridisation (aCGH) and multicolour fluorescence in situ hybridisation (mFISH). Fifteen ATP-binding cassette transporters and numerous new genes were overexpressed in CEM/ADR5000 cells. The basic karyotype in CCRF-CEM cells consisted of 47, XX, der(5)t(5;14) (q35.33;q32.3), del(9) (p14.1), +20. CEM/ADR5000 cells acquired additional aber…
Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines.
2018
Multi-drug resistance (MDR) is a critical problem in cancer chemotherapy. MDR causes the overexpression of ATP-binding cassette (ABC) transporters and mutations in tumor suppressor genes and oncogenes. To tackle this issue, in this study, we focused on Nuphar plants, which have been traditionally used as food. Sesquiterpene alkaloids (1–3) were isolated from N. japonicum and dimeric sesquiterpene thioalkaloids (4–10) were isolated from N. pumilum. P-glycoprotein-overexpressing CEM/ADR5000 cells were cross-resistant to 6,6′-dihydroxythiobinupharidine (10). Using in silico molecular docking, we calculated the binding energies and simulated the interactions of these compounds with the correspo…
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …