Search results for "EMMA"

Genome-wide homozygosity in Maremmana cattle

2017

The current availability of large numbers of single nucleotide polymorphisms (SNPs) throughout the genome makes these markers particularly suitable for the detection of patterns of genetic diversity and of genome-wide homozygosity in animal populations. The aim of this work was to estimate genetic diversity and homozygosity in the Maremmana cattle breed. We used a sample of 149 animals (males and females) geno-typed with the BovineSNP50 v2 (54K) Illumina BeadChip. After editing for call-rate >0.9 and removing SNP unassigned or on the sex chromosomes, 128 animals and 50,814 SNPs were left. We estimated the following genetic parameters: observed and expected heterozygosity (Ho and He), minor …

Atomic Decomposition of Weighted Besov Spaces

1996

We find the atomic decomposition of functions in the weighted Besov spaces under certain factorization conditions on the weight. Introduction. After achieving the atomic decomposition of Hardy spaces (see [8,22, 33]), many of the function saces have been shown to admit similar decompositions. Let us mention the decomposition of B.M.O. (see [32, 25]), Bergman spaces (see [9, 23]), the predual of Bloch space (see [ 11]), Besov spaces (see [15, 4, 10]), Lipschitz spaces (see [18]), Triebel-Lizorkin spaces (see [16, 31]),... They are obtained by quite different methods, but there is a unified and beautiful approach to get the decomposition for most of the spaces. This is the use of a formula du…

Glycemic Variability, Glycated Hemoglobin, and Cardiovascular Complications: Still a Dilemma in Clinical Practice

2021

Persoona ja yhteisö : personalistinen sosiaalipedagogiikka

2002

Toimintaterapeuttien ja vanhempien yhteistyö toimintaterapiassa lapsille, joilla on CP-oireisto

2017

Tutkimuksessa selvitettiin toimintaterapeuttien ja vanhempien välistä yhteistyötä Kelan järjestämässä vaikeavammaisten kuntoutuksessa lapsille, joilla oli CP-oireisto. Tutkimuksessa käytettiin aineistoa, joka oli kerätty Kelan kuntoutuksen avopalveluja tuottaneilta toimintaterapeuteilta vuosina 2008–2009. Aineisto kerättiin The Measure of Processes of Care for Service Providers -itsearviointimittarilla (MPOC-SP), jolla kysyttiin palveluntuottajilta, kuinka paljon he olivat toteuttaneet asiakaslähtöisiä toimintatapoja yhteistyössään lasten vanhempien kanssa. Tämän tutkimuksen aineisto analysoitiin SPSS-ohjelmalla. Tutkimuksen tuloksina oli, että lasta kuntouttavista toimintaterapeuteista 92 …

Insights into Genetic Diversity, Runs of Homozygosity and Heterozygosity-Rich Regions in Maremmana Semi-Feral Cattle Using Pedigree and Genomic Data

2020

Semi-feral local livestock populations, like Maremmana cattle, are the object of renewed interest for the conservation of biological diversity and the preservation and exploitation of unique and potentially relevant genetic material. The aim of this study was to estimate genetic diversity parameters in semi-feral Maremmana cattle using both pedigree- and genomic-based approaches (FIS and FROH), and to detect regions of homozygosity (ROH) and heterozygosity (ROHet) in the genome. The average heterozygosity estimates were in the range reported for other cattle breeds (HE=0.261, HO=0.274). Pedigree-based average inbreeding (F) was estimated at 4.9%. The correlation was low between F and genomi…

Dystrophin-deficiency increases the susceptibility to doxorubicin-induced cardiotoxicity

2007

Background and aim: The clinical use of doxorubicin (DOX) and other anthracyclines is limited by a dosage-dependent cardiotoxicity, which can lead to cardiomyopathy. The role of the individual genetic makeup in this disorder is poorly understood. Alterations in genes encoding cardiac cytoskeleton or sarcolemma proteins may increase the susceptibility to doxorubicin-related cardiotoxicity. Methods: Female dystrophin-deficient mice (MDX) and age-matched wild-type mice underwent chronic treatment with doxorubicin. Cardiac function and tissue damage were assessed by echocardiography and histopathology, respectively. Gene expression changes were investigated using microarrays. Results: DOX treat…

Reversible stress-induced lipid body formation in fast twitch rat myofibers

2012

We analyzed the existence of lipid bodies (LBs) in the fast twitch rat flexor digitorum brevis (FDB) myofibers and found that these structures were scarce. However, isolation procedure of the myofibers, heath shock, viral infection or the glycosylation inhibitor tunicamycin induced formation of the LBs, which were stationary structures flanking Z lines. We next infected FDB myofibers with recombinant Semliki Forest virus expressing caveolin 3-yellow fluorescent protein (cav3-YFP) since this chimeric protein was targeted to the LBs facilitating their further analysis. Photobleaching experiments showed that the LBs recovered cav 3-YFP extremely slowly, indicating that they were not continuous…

Protein targeting to the plasma membrane of adult skeletal muscle fiber: an organized mosaic of functional domains.

2001

The plasma membrane of differentiated skeletal muscle fibers comprises the sarcolemma, the transverse (T) tubule network, and the neuromuscular and muscle-tendon junctions. We analyzed the organization of these domains in relation to defined surface markers, beta-dystroglycan, dystrophin, and caveolin-3. These markers were shown to exhibit highly organized arrays along the length of the fiber. Caveolin-3 and beta-dystroglycan/dystrophin showed distinct, but to some extent overlapping, labeling patterns and both markers left transverse tubule openings clear. This labeling pattern revealed microdomains over the entire plasma membrane with the exception of the neuromuscular and muscle-tendon j…

A comparative study between Chinese and Finns : communication accommodation and values exchange in grandparent and grandchild communication

2017

This study explores differences and similarities between grandparent-grandchild (GP-GC) communication in China and Finland. GP-GC communication and relationship has been understudied for decades since scholars in family communication domain have been focusing on relationships among other family members. The culture of the residents of China, the origin of Confucianism, is isolated from that of other East Asian nations. In view of dramatic socioeconomic development, examining how the traditional GP-GC relationship within the family has changed is valuable. On the other hand, Finland possesses a culture with contrasting traits. Characterized by individualism, Finns are prone to focus primaril…