Search results for "ENRICHMENT"

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…

Thermophilic hydrogen production from cellulose with rumen fluid enrichment cultures: Effects of different heat treatments

2011

Elevated temperatures (52, 60 and 65 °C) were used to enrich hydrogen producers on cellulose from cow rumen fluid. Methanogens were inhibited with two different heat treatments. Hydrogen production was considerable at 60 °C with the highest H2 yield of 0.44 mol-H2 mol-hexose -1 (1.93 mol-H2 mol-hexose-degraded-1) as obtained without heat treatment and with acetate and ethanol as the main fermentation products. H2 production rates and yields were controlled by cellulose degradation that was at the highest 21%. The optimum temperature and pH for H2 production of the rumen fluid enrichment culture were 62 °C and 7.3, respectively. The enrichments at 52 and 60 °C contained mainly bacteria from …

Impact of food fortification on nutritional outcomes and satisfaction in the older people: A systematic literature review protocol

2021

Malnutrition, a recognized pathology in the older adults, corresponds to an imbalance of nutritional intake compared to the body's needs. To treat this disease, several alternatives can be used, among which there is food fortification. Food-based fortification (also known as dietary enrichment) corresponds to the addition of conventional foods or high calorie and/or nutrients ingredients in the person's meals and dishes. It is a strategy used to treat moderate and severe malnutrition but can be employed as prevention. In this context, the purpose of the present study was to conduct a systematic review of all studies related to the nutritional and satisfaction issue of fortified foods dedica…

First determination of β-delayed multiple neutron emission beyond A = 100 through direct neutron measurement : The P2n value of 136Sb

2018

Background: β-delayed multiple neutron emission has been observed for some nuclei with A≤100, being the Rb100 the heaviest β2n emitter measured to date. So far, only 25P2n values have been determined for the ≈300 nuclei that may decay in this way. Accordingly, it is of interest to measure P2n values for the other possible multiple neutron emitters throughout the chart of the nuclides. It is of particular interest to make such a measurement for nuclei with A>100 to test the predictions of theoretical models and simulation tools for the decays of heavy nuclei in the region of very neutron-rich nuclei. In addition, the decay properties of these nuclei are fundamental for the understanding of a…

Growth of Mytilus galloprovincialis (mollusca, bivalvia) close to fish farms: a case of integrated multi-trophic aquaculture within the Tyrrhenian Sea

2009

A current practice of marine aquaculture is to integrate fish with low-trophic-level organisms (e.g. molluscs and/or algae) during farming to minimise effects of cultivation on the surrounding environment and to potentially increase economic income. This hypothesis has been tested in the present article experimentally, by co-cultivating fish and mussels (Mytilus galloprovincialis) in the field. Integrated multi-trophic aquaculture (IMTA) experiments were started in July 2004 by transplanting mussel seed at two depths (-3 and -9 m) within 1,000 m downstream to fish cages and at 1,000 m upstream from cages. Mussels were cultured in nylon net bags for 12 months and the growth recorded biometri…

Query expansion and semantic visualization in information system cooperations : methods and tools for information retrieval

2010

This thesis presents approaches and tools for information retrieval. Our work is part of a cooperation system based on ontologies called OWSCIS (Ontology and Web Service based Cooperation of Information Sources). We treat the problem of information retrieval by providing an enrichment method called QUEXME (QUery EXpansion MEthod) of queries based on analysis of user behavior and using the concept importance notion with regards to query. We also discussed the problem of visualization in the OWSCIS system offering a architecture of service visualization. It is composed of three modules: the request, enrichment and results. The approaches proposed in this thesis have been prototyped and the te…

Redesigning work in university classrooms: factors related to satisfaction in engineering and business administration students

2014

Objeto: Con este trabajo se pretende analizar cómo afectan las características del contexto del aprendizaje, es decir, cómo es el trabajo de los estudiantes en la asignatura, al potencial motivador de la asignatura y a la satisfacción de los estudiantes. Diseño/metodología/enfoque: Mediante ecuaciones estructurales (SEM) se ha analizado los datos de una muestra transversal (cursos 2008, 2009 y 2010) de 535 estudiantes de ingeniería industrial y administración de empresas, de una universidad pública española. Aportaciones y resultados: Los resultados, utilizando un instrumento validado y adaptado al mundo docente, demuestran la asociación existente entre las características del tipo de traba…

Česko-polské jazykové vztahy z historického hlediska

2011

Polycyclic aromatic hydrocarbons and trace metal contamination of coastal sediment and biota from Togo

2011

The state of contamination of tropical environments, particularly in Africa, remains a relatively under explored subject. Here, we determined polycyclic aromatic hydrocarbon (PAH) and trace metal concentrations in coastal sediment and biota samples (fish and mussels) from Togo (West Africa). In the sediments, the ∑21 PAH concentrations ranged from4 ng g(-1) to 257 ng g(-1), averaging 92 ng g(-1). Concentration ratios of low molecular weight PAHs (2-3 rings) versus high molecular weight PAHs (≥4 rings) were always lower than 1 (ranging from 0.08 to 0.46) indicating that high molecular weight PAHs were dominant in all sediment samples, and that PAHs originated mainly from anthropogenic combus…

Differential binding cell-SELEX method to identify cell-specific aptamers using high-throughput sequencing

2018

AbstractAptamers have in recent years emerged as a viable alternative to antibodies. High-throughput sequencing (HTS) has revolutionized aptamer research by increasing the number of reads from a few (using Sanger sequencing) to millions (using an HTS approach). Despite the availability and advantages of HTS compared to Sanger sequencing, there are only 50 aptamer HTS sequencing samples available on public databases. HTS data in aptamer research are primarily used to compare sequence enrichment between subsequent selection cycles. This approach does not take full advantage of HTS because the enrichment of sequences during selection can be due to inefficient negative selection when using live…