Search results for "ENaC"
showing 10 items of 307 documents
Relationship between rheological properties, in vitro release and in vivo equivalency of topical formulations of diclofenac.
2019
Determination of bioequivalence remains a challenge in generic topical drug development. To support pharmacokinetic studies, strategies to demonstrate microstructure sameness of the products being compared include in vitro evaluations, such as the comparison of rheological properties, droplet size and in vitro release rates. Nevertheless, defining the appropriate acceptance range to consider equivalence between test and reference formulation is complex. To shed more light into this issue, in vitro release and rheological properties were compared to in vivo bioequivalence data (systemic blood measurements within a clinical trial) after topical application of a single dose. Test and reference…
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery
2002
Background Ketorolac is approved for the relief of postoperative pain but concerns have been raised over a possible risk of serious adverse effects and death. Two regulatory reviews in Europe on the safety of ketorolac found the data were inconclusive and lacked comparison with other non-steroidal anti-inflammatory drugs. The aim of this study was to compare the risk of serious adverse effects with ketorolac vs diclofenac or ketoprofen in adult patients after elective major surgery. Methods This prospective, randomized multicentre trial evaluated the risks of death, increased surgical site bleeding, gastrointestinal bleeding, acute renal failure, and allergic reactions, with ketorolac vs di…
Postoperative pain therapy after lumbar disc surgery.
2000
Object. This study was undertaken to determine whether a special postoperative pain administration of tramadol and diclofenac provides any benefits in patients who underwent microsurgical lumbar discectomy. Methods. The study consisted of 60 patients undergoing microsurgical lumbar discectomy. Patients were randomly divided into two groups based on the postoperative pain management: 1) Group A (n=30): no standardized pain therapy; these patients received on demand different analgesics and at variable dosages which were selected by the neurosurgeons; 2) Group B (n=30): standardized pain therapy with specific dosages of tramadol and diclofenac in regular time intervals during the first 48 ho…
Analgesic effects of nonsteroidal anti-inflammatory drugs in cancer pain due to somatic or visceral mechanisms.
1999
The role of nonsteroidal anti-inflammatory drugs (NSAIDs) is well established in the treatment of cancer pain. This class of drugs is considered particularly effective in pain due to somatic mechanisms, although proof of this observation is lacking. To ascertain whether NSAIDs are more effective in specific nociceptive forms of cancer pain, they were administered alone or added to opioids in 32 patients with a sole pain mechanism, somatic pain due to bone metastases (17 patients) or visceral pain (15 patients), respectively. Pain intensity, mean doses of opioids used, and symptoms were recorded after starting NSAID. A significant reduction in pain intensity was found at 3, 7, and 14 days. N…
Assessment of natural hazards in urban planning policies of the municipalities in the province of Alicante (Spain). Legislation and risk mapping
2018
Los espacios urbanos se han convertido en territorios proclives al daño económico y pérdida de vidas humanas con ocasión de episodios de rango extremo de origen natural. Ello es debido a la acumulación de población y actividades en el medio urbano y a la deficiente planificación urbana, que no ha tenido en cuenta, hasta fechas muy recientes, el problema de la peligrosidad natural y sus efectos territoriales en los procesos de asignación de usos en el suelo. El objetivo de esta investigación es analizar el grado de cumplimiento de la obligación de incorporar cartografía de riesgo en la documentación de planeamiento urbanístico en la provincia de Alicante a partir de 2008. Para ello, se ha co…
TAP Block Prior to Open Ventral Hernia Repair Improves Surgical Outcome.
2022
Abstract Background Ventral hernias commonly affect patients after major abdominal surgery. To reduce postoperative pain, the effects of the transversus abdominis plane (TAP) block, epidural analgesia and medication-only protocol have been investigated. The primary outcome was the cumulative dosage of opioids (morphine milligram equivalents MME), of acetaminophen and diclofenac for postoperative pain control on postoperative day (POD) 0, 1, and 2. Secondary outcomes were length of stay (LOS) and the pain scale rating using the numeric rating scale (NRS) on POD 0, 1, and 2. Methods The data were retrospectively extracted from the charts of the patients admitted for a surgical operation for O…
Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil
2012
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Modelo mental y modelo social en la construcción de un lexicón en aprendices italianos de Espanol como lengua segunda. Una perspectiva enactiva
2016
El artículo se propone investigar desde una perspectiva enactiva la enseñanza del español como lengua segunda a aprendices italianos. Desde una perspectiva neurofenomenológica se abordará el tema de la adquisición de una competencia lingüística en lengua española, con el propósito de demostrar cómo la construcción del lexicón mental en la L2 para por el filtro de la experiencia en la LM.
Riella cossoniana Trab. (Riellaceae, Marchantiophyta) new to France
2014
Riella (Riellaceae, Sphaerocarpales) is a genus of aquatic liverworts with disjunct range in areas of Mediterranean-type climates. Riella has been traditionally subdivided into two subgenera, subgenus Riella, whose plants show smooth or papillose female involucres and Trabutiella, whose plants show winged female involucres. To date only three species of Riella are known in France, all belonging to subgenus Riella. During the course of a study of the plant diversity of temporary brackish ponds in the Camargue area (Southern France), soil sediments were collected from 10 localities and cultivated in the laboratory. From cultures of five of these localities emerged dioicous plants of Riella sh…
Riella bialata Trab. (Riellaceae, Marchantiophyta): A new addition to the European liverwort flora
2013
[EN] Riella (Riellaceae, Sphaerocarpales) is a genus of aquatic liverworts with a disjunct worldwide distribution in areas of seasonal Mediterranean-type climates. Its centre of diversity is located in the Mediterranean basin, where about half the species number of the genus is concentrated. In the course of a worldwide revision of the genus Riella, plants from a monoicous species with wingless, not papillose and smooth involucres were found in two distant Iberian localities. These plants showed a geminate dorsal wing, unlike the single wing occurring in the remaining species of the genus. This character unambiguously assigns these populations to R. bialata, a species known to date from a s…