Search results for "EOS"
showing 10 items of 2714 documents
Dabisko likumu simulācija un tās ietekme uz emocijām
2022
Darba “Dabisko likumu simulācija un tās ietekme uz emocijām” mērķis ir izpētīt dažādu ģeometrijas un fizikas likumu simulācijas spēlēs un to ietekmi uz cilvēka emocijām. Pētījumā ir iesaistītas netriviālās animācijas, kas izmantotas spēlēs un informatīvajos videoklipos, un pētīt lietotāju emocionālo spektru pēc to noskatīšanas. Eksperimentā pētītās simulācijas tika novērtētas pēc reālistiskuma un tika sniegti vairāki viedokļi par to pozitīviem un negatīviem aspektiem. Pētījuma rezultāti var tikt pielietojami simulāciju modelēšanas uzlabojumos dažādās digitālās vidēs.
Aproximaciones moleculares al estudio de las interacciones de rotavirus y norovirus con el huésped
2020
Los norovirus humanos son los principales agentes etiológicos de gastroenteritis aguda en todo el mundo. Aunque los norovirus son muy diversos (se han detectado más de 30 genotipos en humanos), durante los últimos 40 años la mayoría de los brotes y epidemias han sido causados por cepas del genotipo GII.4, lo que plantea interrogantes sobre su persistencia en la población. Entre otras posibles explicaciones, se considera que la evasión inmunológica es la principal causa de su éxito. Para estudiar en detalle el reconocimiento y la evasión de anticuerpos, analizamos un epítopo conformacional reconocido por un anticuerpo monoclonal (3C3G3) mediante mutagénesis dirigida y resonancia superficial …
Kielestä yleensä
2010
Kirja-arvio: [Ojutkangas, Krista & Larjavaara, Meri & Miestamo, Matti & Ylikoski, Jussi: Johdatus kielitieteeseen] nonPeerReviewed
High Angular Resolution ALMA Images of Dust and Molecules in the SN 1987A Ejecta
2019
We present high angular resolution (~80 mas) ALMA continuum images of the SN 1987A system, together with CO $J$=2 $\!\rightarrow\!$ 1, $J$=6 $\!\rightarrow\!$ 5, and SiO $J$=5 $\!\rightarrow\!$ 4 to $J$=7 $\!\rightarrow\!$ 6 images, which clearly resolve the ejecta (dust continuum and molecules) and ring (synchrotron continuum) components. Dust in the ejecta is asymmetric and clumpy, and overall the dust fills the spatial void seen in H$\alpha$ images, filling that region with material from heavier elements. The dust clumps generally fill the space where CO $J$=6 $\!\rightarrow\!$ 5 is fainter, tentatively indicating that these dust clumps and CO are locationally and chemically linked. In t…
Las actividades de imagen y el funcionamiento de la atenuación en correos electrónicos del ámbito empresarial: un estudio contrastivo de los estilos …
2022
Esta tesis trata de investigar y determinar diferencias y semejanzas sociopragmáticas en el modo en que se configuran las actividades de imagen y la atenuación en correos electrónicos del ámbito de las empresas de españoles y brasileños. Los dos objetivos generales de este trabajo consisten en: i) elaborar un corpus lingüístico especializado y representativo de correos electrónicos del entorno de las organizaciones en portugués y en español y ii) verificar la influencia de determinadas variables enunciativas, estructurales y situacionales en la manifestación de las actividades de imagen y de la atenuación usadas en dicho corpus. Para ello, en primer lugar, se repasan algunos estudios acerca…
Eksperiments metodoloģijā: Starp “Virtuālo” un “Īsto”
2018
Bakalaura darbs “Eksperiments metodoloģijā: Starp “Virtuālo” un “Īsto”” fokusējas uz video spēļu spēlētāju imersīvām pieredzēm, kuras izraisa masīvās daudzspēlētāju tiešsaistes lomu spēles World of Warcraft virtuālās pasaules vizuālās un skaņas ainavas. Es skatu virtuālu spēļu pasauli kā digitālu kultūras artefaktu, kas sastāv no vairākām mākslas formām, un es pievēršu uzmanību veidiem, kādos šīs mākslas formas var sekmēt cilvēku radošumu un imersiju, kā arī dzīves uzskatus un tās trajektoriju virzienus ārpus virtuālā lauka. Konceptualizējot virtuālās ainavas kā atmiņu piesātinātas, es atsedzu un analizēju neaizmirstamas cilvēku pieredzes dziļumu, kas tajās ir iesakņots. Eksperiments ar etn…
Comparing tacrolimus ointment and oral cyclosporine in adult patients affected by atopic dermatitis: a randomized study
2004
BACKGROUND: Atopic dermatitis (AD) is a chronic allergic inflammatory disease, which manifests itself with eczematous skin lesions. OBJECTIVE: We compared the clinical efficacy of tacrolimus ointment (0.1%) given twice a day and oral cyclosporine (3 mg/kg) given once daily. Rescue medication for itching included cetirizine 10-20 mg (equal to one or two tables). METHODS: Thirty patients, aged 13-45 years (mean+/-SD 27.1+/-10.9), with a history of moderate-to-severe AD were randomized to treatments, 15 patients for each treatments. Assessment of efficacy was based on SCORAD, on scores of daily itching, erythema, interference with sleep, due to the skin condition and days without use of cetiri…
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
2019
Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memory, and the described pleiotropic neuroprotective effects in various experimental paradigms, Sig-1R activation is recognized as one potential approach for prevention and therapy of neurodegeneration and, interestingly, in amyotrophic lateral sclerosis associated with mutated Sig-1R, autophagy is disturbed. Here we analyzed the effects of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hyd…
The Role of Autophagy in Eye Diseases
2021
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellula…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…