Search results for "EPA"
showing 10 items of 8995 documents
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
2020
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
TENSION FREE CYSTOCELE REPAIR. FOUR YEARS FOLLOW-UP
2003
Aims of study: Anterior vaginal wall descensus is one of the most frequent alteration in patients with pelvic defects. At least 50% of women that had delivered two or more times presented a certain degree of this pathologic alteration of the anatomy, even thought only 10-20% of the patients complained of associated pains. The use of synthetic biocompatible materials has become more common in gynecology surgery(1)-(3). Polypropylene mesh to be proposed as a mean of surgical correction of moderate severe cystocele (Cervigni 1998)(2) Methods: 97 patients aged 42-75, parity 1-5, body weight 45-90, menopause 41 pts. (61%).Irritative sintoms( nocturia, frequency, urgency, dysuria and urge inconti…
Kattaustavararyhmän määrittely ja esillepano kuluttajan näkökulmasta : case: Kattaustavarat, Duni & Havi oy
2001
Valor social subjetivo de la educación para el profesorado: bases para la construcción de un instrumento de medida
2013
En el siguiente trabajo de final de máster se tratará de una temática novedosa a nivel científico: El valor social de la educación 1(VSE)2 concretamente para el profesorado. Y por eso, además de hacer un estudio teórico y proponer una serie de términos en relación con el tema, aportaremos las bases para el diseño de un instrumento de medida que nos permita valorar el valor social que le da el profesorado a su trabajo. Lo primero que encontraremos será la motivación y utilidad del estudio en relación al máster estudiado para luego comparar nuestra definición del (VSE) y sus variantes con las pocas ya existentes a nivel científico. Tras esto, buscaremos aproximaciones al término y a las dimen…
Valsts atbildība par normatīvu aktu kā nepamatotu tiesību aizskārumu
2016
Maģistra darba mērķis ir izpētīt, vai pastāv un kādos gadījumos pastāv valsts atbildība par normatīviem aktiem un tā tiesību normām, kā arī sniegt ierosinājumus šīs jomas tiesiskā regulējuma pilnveidošanai, ja valstij var iestāties atbildība arī par tā pieņemtiem normatīviem aktiem un tā tiesību normām. Lai sasniegtu maģistra darba mērķi, tika veikta padziļināta tiesību doktrīnas, normatīvo aktu, nacionālo, ārvalstu un pārnacionālo tiesu prakses, kā arī citu valstu parlamentu un tieslietu ministriju vēstuļu izpēte. Darbā izvērtēta ne tikai valsts atbildība par valsts pieņemtiem ārējiem normatīviem aktiem, bet arī par iekšējiem normatīviem aktiem un to tiesību normām. Darba autors galvenokār…
Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus
2019
Background. Management of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available. Methods. Given this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×…
New developments in the management of hepatitis C virus infection: focus on boceprevir
2012
Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.
The effect of carvacrol on enteric viruses.
2014
Carvacrol, a monoterpenic phenol, is said to have extensive antimicrobial activity in a wide range of food spoilage or pathogenic fungi, yeast and bacteria. The aim of this study was to assess its antiviral activity on norovirus surrogates, feline calicivirus (FCV), murine norovirus (MNV), and hepatitis A virus (HAV), as well as its potential in food applications. Initially, different concentrations of carvacrol (0.25, 0.5, 1%) were individually mixed with each virus at titers of ca. 6-7 log TCID50/ml and incubated 2h at 37°C. Carvacrol at 0.5% completely inactivated the two norovirus surrogates, whereas 1% concentration was required to achieve ca. 1 log reduction of HAV. In lettuce wash wa…
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …