Search results for "EPO"
showing 10 items of 6062 documents
La creación de peñas de mujeres: ¿Un desafio a la configuración del sistema sexo/género en el futbol espanol?
2017
Este artículo presenta los resultados de una investigación sobre las peñas de mujeres en el fútbol español. Teniendo en cuenta el ethos o carácter masculino que tradicionalmente ha caracterizado a este deporte, el estudio de las peñas de mujeres encierra un indudable interés socioantropológico por cuanto puede proporcionar una mejor comprensión de las dinámicas que operan en este deporte en relación con la dimensión de género. La investigación ha estado guiada por una pregunta: ¿hasta qué punto puede afirmarse que la creación de peñas de mujeres constituye un desafío a la configuración del sistema sexo/género que caracteriza al fútbol en la sociedad española? Más concretamente, se han abord…
‘We hugged each other during the cold nights’: the role of affect in an anti-deportation protest network in Finland
2021
This article analyses the role of affect and emotions in Finland’s first large-scale anti-deportation protest, the 2017 Right to Live protest in Helsinki. Despite deportation protests having recently gained scholarly attention, their emotional dimensions have not been sufficiently studied, especially as concerns the emotions of protestors with vulnerable legal status. This article is based on in-depth interviews with key activists in the anti-deportation protest network in Finland, including asylum seekers, refugees and Finnish citizens. The article argues that in order for the protest of asylum seekers facing the threat of deportation to become public and visible, it was important that cit…
The importance of physical education and health to be a core subject: Arguments and postures concerning the curricular modifications in Chile
2021
This study is focused on the declarations made by different Chilean institutions regarding the modifications affecting the subject Physical Education and Health (PEH), which were approved by the National Education Council. Purpose: The main aim was to analyse the speech generated and gather data around the curricular modifications in the 3rd and 4th course of the middle education in 2020, specifically the choice of leaving the subject PEH as an elective subject. Design: A qualitative, pragma-dialectic approach was used, focusing on the point of view and main arguments of the institutions on the topic. Results: 23 declarations were reviewed, pertaining 6 to health institutions, 12 to educati…
Particulated wisdom teeth as an autologous bone substitute for grafting/filling material in bone defects : case Report
2020
Introduction Bone augmentation material using permanent teeth are confirmed in many articles to provide good histological and clinical results. Advances in osteoconduction and osteoinduction, low cost of material, no risk of disease transmission and elimination of foreign body reaction are important aspects not only to the clinician but to patient as well. Many techniques and devices to obtain graft material for bone augmentation out of teeth are found in the literature. Material and Methods The wisdom teeth crush technique developed in our office and described in this case report is simple and no specific devices for teeth grinding were used. The graft material was obtained from impacted i…
Isoenzyme-specific phosphorylation of cytochromes P-450 and other drug metabolizing enzymes.
1987
Abstract A series of fourteen cytochrome P-450 isoenzymes was treated with three different protein kinases and found to devide into isoenzymes phosphorylated (i) by both the cyclic AMP-dependent kinase and the calcium-phospholipid-dependent kinase (P-450 PB 3a and PB 2e), (ii) by none of these kinases (P-450 PB 1b, MC 1b, UT 1, and thromboxane synthase), and (iii) by either the cyclic AMP-dependent kinase (P-450 LM 2, PB 2d, and PB 3b) or the calcium-phospholipid-dependent kinase (P-450 PB 1a, PB 2a, MC 1a, LM 3c, and LM 4). Other components of the monooxygenase system, cytochrome P-450 reductase, cytochrome b5, cytochrome b5 reductase as well as microsomal epoxide hydrolase, were poor subs…
Molecular basis of the functional distinction between Cln1 and Cln2 cyclins
2012
Cln1 and Cln2 are very similar but not identical cyclins. In this work, we tried to describe the molecular basis of the functional distinction between Cln1 and Cln2. We constructed chimeric cyclins containing different fragments of Cln1 and Cln2 and performed several functional analysis that make it possible to distinguish between Cln1 or Cln2. We identified that region between amino acids 225 and 299 of Cln2 is not only necessary but also sufficient to confer Cln2 specific functionality compared with Cln1. We also studied Cln1 and Cln2 subcellular localization identifying additional differences between them. Both cyclins are distributed between the nucleus and the cytoplasm, but Cln1 shows…
Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
2005
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved in APP endocytosis. Here, we show that the APP homolog APLP1 (amyloid precursor-like protein 1) influences APP shedding. In human embryonic kidney 293 cells expression of APLP1 strongly activated APP shedding by alpha-secretase and slightly reduced beta-secretase cleavage. As revealed by domain deletion analysis, the increase in APP shedding re…
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
1999
Protein tyrosine phosphatase PTP-SL retains mitogen-activated protein (MAP) kinases in the cytoplasm in an inactive form by association through a kinase interaction motif (KIM) and tyrosine dephosphorylation. The related tyrosine phosphatases PTP-SL and STEP were phosphorylated by the cAMP-dependent protein kinase A (PKA). The PKA phosphorylation site on PTP-SL was identified as the Ser231 residue, located within the KIM. Upon phosphorylation of Ser231, PTP-SL binding and tyrosine dephosphorylation of the MAP kinases extracellular signal–regulated kinase (ERK)1/2 and p38α were impaired. Furthermore, treatment of COS-7 cells with PKA activators, or overexpression of the Cα catalytic subunit …
Adolescents' medicine use for headache: secular trends in 20 countries from 1986 to 2010
2015
BACKGROUND: This study reports secular trends in medicine use for headache among adolescents in 20 countries from 1986 to 2010.METHODS: The international Health Behaviour in School-aged Children (HBSC) survey includes self-reported data about medicine use for headaches among nationally representative samples of 11-, 13- and 15-year-olds. We included 20 countries with data from at least three data collection waves, with a total of 380 129 participants.RESULTS: The prevalence of medicine use for headaches varied from 16.5% among Hungarian boys in 1994 to 62.9% among girls in Wales in 1998. The prevalence was higher among girls than boys in every country and data collection year. The prevalenc…
Reventilation Episodes During the Sapropel S1 Deposition in the Eastern Mediterranean Based on Holococcolith Preservation
2019
Organic-rich layers (sapropels), preserved in eastern Mediterranean marine sediment records, represent pronounced perturbations to thermohaline circulation and environmental conditions in the basin, in response to enhanced African monsoon activity and subsequent massive freshwater discharge. During the most recent event, Sapropel S1 formed between 10.8 and 6.1 ka, when freshwater-driven stratification caused seafloor anoxia below ~1,800-m depth, as a result of both failure of deep water formation and enhanced productivity. Here we analyze coccolith assemblages from the open eastern Mediterranean that form a west-east transect across the basin and provide insights on past environmental chang…