Search results for "ERAS"
showing 10 items of 4431 documents
Mechanism of sulfur transfer across protein-protein interfaces: The cysteine desulfurase model system
2016
CsdA cysteine desulfurase (the sulfur donor) and the CsdE sulfur acceptor are involved in biological sulfur trafficking and in iron-sulfur cluster assembly in the model bacterium Escherichia coli. CsdA and CsdE form a stable complex through a polar interface that includes CsdA Cys328 and CsdE Cys61, the two residues known to be involved in the sulfur transfer reaction. Although mechanisms for the transfer of a sulfur moiety across protein-protein interfaces have been proposed based on the IscS-IscU and IscS-TusA structures, the flexibility of the catalytic cysteine loops involved has precluded a high resolution view of the active-site geometry and chemical environment for sulfur transfer. H…
Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome
2019
The deficiency of the molybdenum cofactor (Moco) is an autosomal recessive disease, which leads to the loss of activity of all molybdoenzymes in humans with sulfite oxidase being the essential protein. Moco deficiency generally results in death in early childhood. Moco is a sulfur-containing cofactor synthesized in the cytosol with the sulfur being provided by a sulfur relay system composed of the L-cysteine desulfurase NFS1, MOCS3, and MOCS2A. Human MOCS3 is a dual-function protein that was shown to play an important role in Moco biosynthesis and in the mcm(5)s(2) U thio modifications of nucleosides in cytosolic tRNAs for Lys, Gln, and Glu. In this study, we constructed a homozygous MOCS3 …
Iron Induces Proliferation and Morphogenesis in Primmorphs from the Marine SpongeSuberites domuncula
2002
Dissociated cells from marine demosponges retain their proliferation capacity if they are allowed to form special aggregates, the primmorphs. On the basis of incorporation studies and septin gene expression, we show that Fe3+ ions are required for the proliferation of cells in primmorphs from Suberites domuncula. In parallel, Fe3+ induced the expression of ferritin and strongly stimulated the synthesis of spicules. This result is supported by the finding that the enzymatic activity of silicatein, converting organosilicon to silicic acid, depends on Fe3+. Moreover, the expression of a scavenger receptor molecule, possibly involved in the morphology of spicules, depends on the presence of Fe3…
Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials
2019
[EN] Mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine.
Prolin-benzylester als chirale Hilfsgruppen in asymmetrischen 1,3-dipolaren Cycloadditionen mit Nitriloxiden
1990
Proline Benzyl Esters as Chiral Auxiliaries in Asymmetric 1,3-Dipolar Cycloadditions N-Acryloylproline benzyl ester (1b) reacts with nitrile oxides at temperatures from −78 to 0°C to give isoxazolines 4/5 with diastereomeric ratios of ca. 3:1 and with the (5S) isomer as the predominating. The corresponding N-methacryloylproline benzyl ester (1c) gives inferior results. The diastereoselectivity is not influenced by the temperature and the substituents of the nitrile oxides. To prove the absolute configuration of the predominating stereoisomer, a reaction sequence is developed which makes use of an enantioselective hydrolysis with pig liver esterase as the key step to generate an optically ac…
Inovatīvas uzvedības un radošumu kavējošo faktoru sakarības darbiniekiem uzņēmumā X
2019
Pētījuma mērķis bija noskaidrot darbinieku radošuma kavējošo faktoru un inovatīvas uzvedības sakarību uzņēmumā. Augsta līmeņa uzņēmumi veicina un novērtē inovatīvu uzvedību darbā, kas ir nepieciešama, lai veidotu inovatīvu klimatu organizācijā (Hirst et al., 2009; kā minēts Černe, Dysvik, Škerlavaj, 2017). Tādējādi zinātnieki ir uzsvēruši inovāciju nozīmi personāla vadības un uzņēmuma vadības kontekstā (Scott and Bruce, 1994; Axtell et al., 2000; kā minēts Černe, Dysvik, Škerlavaj, 2017). Uzņēmumā radošs darbinieks, kurš vēlas riskēt un cenšas izzināt nezināmo, veicina jaunu risinājumu un daudzu alternatīvu meklēšanu problēmu risināšanai un pieņem atbilstošu lēmumu, lai atrisinātu problēmu …
The role of agroecosystems for invasion of a generalist herbivore
2014
Suomen kielen ja kotityöpalveluopintojen integrointikäytänteet ammatillisessa suomi toisena kielenä -opetuksessa kotityöpalvelujen ammattitutkinnossa
2017
Maisterintutkielmassani käsittelen suomen ja kotityöpalveluopintojen sisältöjen integrointia suomen ja kotityöpalvelujen opinnoissa ammatillisessa S2-opetuksessa. Tavoitteenani on selvittää, kuinka suomea ja kotityöpalveluopintoja integroidaan ja mihin sillä pyritään. Laadullinen tutkimukseni sijoittuu toisen kielen pedagogiikan tutkimuskenttään. Työni teoriatausta nojautuu erilaisiin integroidun opetuksen määritelmiin, CLIL-näkökulmiin sekä konstruktivismiin, sosiokonstruktivismiin ja joihinkin kielikäsityksiin. Aineistoni koostuu kahdesta haastattelusta ja yhdestä täydentävästä viestistä. Keräsin aineistoni teemahaastattelua käyttäen yhdeltä suomenopettajalta ja kotityöpalvelujen opettaja…
Diseño y organización del seminario de relaciones internacionales y cooperación en un centro de Educación Secundaria
2021
Los centros de Educación Secundaria han de estar abiertos al cambio y a su entorno. Desde los equipos directivos debemos optimizar las oportunidades que se presentan para que los discentes estén mejor preparados para actuar en una sociedad más móvil, multicultural y digital. Se considera que en este mundo globalizado que vivimos, los centros educativos deben promover, gestionar, organizar la movilidad de estudiantes y profesorado en el ámbito del Programa europeo Erasmus+; Formación en Centros de trabajo (FCT Europa) y Proyectos eTwinning. En consecuencia, los centros hemos de incorporar en su organización una dimensión internacional. En esta experiencia presentamos el diseño, creación y or…